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1824; p = 0.0123), while high bacterial load combined with the increased number of FOXP3+ cells is a marker of poor prognosis (HR = 4.651; p = 0.0116). Thus, we established that bacterial load of the tumor has an opposite prognostic value depending on the status of local antitumor immunity.Radiometric calibration of laser-based, topographic lidar sensors that measure range via time of flight or phase difference is well established. However, inexpensive, short-range lidar sensors that utilize non-traditional ranging techniques, such as indirect time of flight, may report radiometric quantities that are not appropriate for existing calibration methods. One such lidar sensor is the TeraRanger Evo 60 m by Terabee, whose reported amplitude measurements do not vary smoothly with the amount of return signal power. We investigate the performance of a new radiometric calibration model, one based on a neural network, applied to the Evo 60 m. The proposed model is found to perform similarly to those applied to traditional lidar sensors, with root mean square errors in predicted target reflectance of no more than ±6% for non-specular surfaces. The radiometric calibration model provides a generic approach that may be applicable to other low-cost lidar sensors that report return signal amplitudes that are not smoothly proportional to target range and reflectance.The research and development of modern metallic materials goes hand in hand with increasing their lifetime via optimized deformation processing. The presented work deals with preparation of an Al/Cu clad composite with implemented reinforcing Cu wires by the method of twist channel angular pressing (TCAP). Single and double pass extrusion of the clad composite was simulated numerically and carried out experimentally. This work is unique as no such study has been presented so far. Ruboxistaurin Detailed monitoring of the deformation behavior during both the passes was enabled by superimposed grids and sensors. Both the sets of results revealed that already the single pass imparted significant effective strain (higher than e.g., conventional equal channel angular pressing (ECAP)), especially to the Al matrix, and resulted in notable deformation strengthening of both the Al and Cu composite components, which was confirmed by the increased punch load and decreased plastic flow velocity (second pass compared to first pass). Processing via the second pass also resulted in homogenization of the imposed strain and residual stress across the composite cross-section. However, the investigated parameters featured slight variations in dependence on the monitored location across the cross-section.Product miniaturization is a trend for facilitating product usage, enabling product functions to be implemented in microscale geometries, and aimed at reducing product weight, volume, cost and pollution. Driven by ongoing miniaturization in diverse areas including medical devices, precision equipment, communication devices, micro-electromechanical systems (MEMS) and microsystems technology (MST), the demands for micro metallic products have increased tremendously. Such a trend requires development of advanced micromanufacturing technology of metallic materials for producing high-quality micro metallic products that possess excellent dimensional tolerances, required mechanical properties and improved surface quality. Micromanufacturing differs from conventional manufacturing technology in terms of materials, processes, tools, and machines and equipment, due to the miniaturization nature of the whole micromanufacturing system, which challenges the rapid development of micromanufacturing technology. Against such a background, the Special Issue "Micromanufacturing of Metallic Materials" was proposed to present the recent developments of micromanufacturing technologies of metallic materials. The papers collected in the Special Issue include research articles, literature review and technical notes, which have been highlighted in this editorial.micromanufacturing; metallic materials; miniaturization; micro products.Accumulation of biologically active metabolites is a specific feature of plant biochemistry, directing the use of plants in numerous applications in the pharmaceutical and food industries. Among these substances, the plethora of phenolic compounds has attracted particular interest among researchers. Here, we report on new findings in phlorotannin research, a large group of multifunctional phenolic substances, produced in brown algae. Comprehensive LC-MS profiling of three algal species allowed us to depict the complex pattern of this structurally diverse compound group across different tissues and subcellular compartments. We compiled more than 30 different phlorotannin series in one sample and used accurate mass spectrometry to assign tentative structures to the observed ions based on the confirmed sum formulas. From that, we found that acetylation, hydroxylation, and oxidation are likely to be the most common in vivo modifications to phlorotannins. Using an alternative data mining strategy to cope with extensive coelution and structural isomers, we quantitatively compared the intensity of different phlorotannin series in species, tissues, and subcellular compartments to learn more about their physiological functions. The structure and intra-thallus profiles of cell wall-bound phlorotannins were studied here for the first time. We suggest that one of the major dibenzodioxin-type phlorotannin series may exclusively target integration into the cell wall of fucoid algae.Background and objectives Recommendations for the control of stable patients with coronary artery disease (CAD) related to an adequate level of physical activity (PA). Practical experience shows that the PA level in most people with CAD is definitely too low in relation to the guidelines. The cause may be psychological factors and among them the fear of movement-kinesiophobia. The aim of this project was to examine the evaluation of psychometric features of the Polish version of the Tampa Scale for Kinesiophobia Heart (TSK Heart), used in people with CAD. Materials and methods The study involved 287 patients with stable CAD 112 women and 175 men. Age 63.50 (SD = 11.49) years. Kinesiophobia was assessed using TSK Heart, physical activity (PA)-using the International Physical Activity Questionnaire (IPAQ), and anxiety and depression was examined using the Hospital Anxiety and Depression Scale (HADS). The structure of TSK was examined using principal component analysis (PCA), internal cohesion (Cronbach's alpha, AC), and content validity was calculated by linear regression.