Carneyliu3842

The aim of this study was to evaluate the roughness of the apical surface after apical resection performed by six different methods with an optical profilometer. Sixty human single root premolar teeth were used in this in vitro study. After root canal preparation, root canals were filled with gutta-percha and AH Plus root canal sealers by lateral condensation technique. The teeth were randomly divided into six groups according to the apical resection method steel fissure bur, tungsten carbide fissure bur, Lindeman bur, diamond fissure bur, laser, and ultrasonic surgical piezo with a diamond tip. The root ends were resected 3 mm away from the root apex and at a 90° angle. The time required for apicectomy was recorded for each group. M4344 After apical resection, the root surfaces were analyzed by an optical profilometer. The Kruskal-Wallis method was used to analyze the differences between groups. The significance level was set at 5%. The roughest surfaces were obtained by laser (25.54 ± 9.01 μm) and Lindeman bur (17.35 ± 6.03 μm), respectively. The longest mean resection times were recorded in piezosurgery and laser surgery (57 ± 14.39 s and 50.9 ± 16.86 s), respectively. Although the diamond-tipped piezo surgical cutting time is long, it has the best results in terms of surface roughness (5.50 ± 1.73 μm). The optical profilometer is a more convenient tool for evaluating the surface after apical surgery, as it provides an opportunity to evaluate objectively with both visual and numerical data.Rewritable information record materials usually demand not only reversibly stimuli-responsive ability, but also strong mechanical properties. To achieve one photochromic hydrogel with super-strong mechanical strength, hydrophobic molecule spiropyran (SP) has been introduced into a copolymer based on ion-hybrid crosslink. The hydrogels exhibit both photoinduced reversible color changes and excellent mechanical properties, i.e., the tensile stress of 3.22 MPa, work of tension of 12.8 MJ m-3 , and modulus of elasticity of 8.6 MPa. Moreover, the SP-based Ca2+ crosslinked hydrogels can be enhanced further when exposed to UV-light via ionic interaction coordination between Ca2+ , merocyanine (MC) with polar copolymer chain. In particular, hydrogels have excellent reversible conversion behavior, which can be used to realize repeatable writing of optical information. Thus, the novel design is demonstrated to support future applications in writing repeatable optical information, optical displays, information storage, artificial intelligence systems, and flexible wearable devices.We demonstrate the benefit of a novel laser strategy in multiphoton microscopy (MPM). The cheap, simple, and turn-key supercontinuum laser system with its spectral shaping module, constitutes an ideal approach for the one-shot microscopic imaging of many fluorophores without modification of the excitation parameters central wavelength, spectral bandwidth, and average power. The polyvalence of the resulting multiplex-multiphoton microscopy (M-MPM) device is illustrated by images of many biomedical models from several origins (biological, medical, or vegetal), generated while keeping constant the spectral parameters of excitation. The resolution of the M-MPM device is quantified by a procedure of point-spread-function (PSF) assessment led by an original, robust, and reliable computational approach FIGARO. The estimated values for the PSF width for our M-MPM system are shown to be comparable to standard values found in optical microscopy. The simplification of the excitation system constitutes a significant instrumental progress in biomedical MPM, paving the way to the imaging of many fluorophores with a single shot of excitation without any modification of the lighting device. RESEARCH HIGHLIGHTS A new solution of multiplex-multiphoton microscopy device is shown, resting on a supercontinuum laser. The one-shot excitation device has imaged biomedical and vegetal models. Our original computational strategy measures usual microscopy resolution.Li-chalcogen batteries, especially the Li-S batteries (LSBs), have received paramount interests as next generation energy storage techniques because of their high theoretical energy densities. However, the associated challenges need to be overcome prior to their commercialization. Elemental selenium, another chalcogen member, would be an attractive alternative to sulfur owing to its higher electronic conductivity, comparable capacity density, and moreover, excellent compatibility with carbonate electrolytes. Unlike LSBs, the research and development of Li-Se batteries (LSeBs) have garnered burgeoning attention but are still in their infant stage, where a comprehensive yet in-depth overview is highly imperative to guide future research. Herein, a critical review of LSeBs, in terms of the underlying mechanisms, cathode design, blocking layer engineering, and emerging solid-state electrolytes is provided. First, the electrolyte-dependent electrochemistry of LSeBs is discussed. Second, the advances in Se-based cathodes are comprehensively summarized, especially highlighting the state-of-the-art Sex Sy cathodes, and mainly focusing on their structures, compositions, and synthetic strategies. Third, the versatile separators/interlayers optimization and interface regulation are outlined, with a particular focus on the emerging solid-state electrolytes for advanced LSeBs. Last, the remaining challenges and research orientations in this booming field are proposed, which are expected to motivate more insightful works.

Cancer patients are increasingly involved in decision-making for cancer treatment. General practitioners' (GPs) support in this process is advocated. Therefore, GPs need to be aware of patients' treatment decision-making process and their potential role. We aim to understand the treatment decision-making process and to explore the added value of GP involvement, from the perspective of cancer patients treated with curative intent.

An explorative qualitative study was performed. Semi-structured interviews were conducted with 20 purposively sampled Dutch cancer patients treated with curative intent.

Patients' treatment decision-making process was dominated by a focus on 'safeguarding survival'. Patients generally followed the treatment plan as proposed by their physician and did not always experience having a treatment choice. The majority of patients expressed added value for GP involvement, mainly to provide psychological support, but also for providing shared decision-making (SDM) support.

The treatment decision-making process of cancer patients treated with curative intent is dominated by the urge to 'safeguard survival'.