Bredahlbridges0284

Acute myeloid leukemia (AML) is a malignant clonal hematopoietic stem cell disease. Although there are many therapeutic options, it is still an incurable hematological malignancy. Moreover, the prognosis of AML is closely related to its cytogenetics and molecular biology. The DEK/CAN fusion gene formed by t (6;9)(p23;q34) occurs with an incidence of 1-5% in adult patients with AML usually indicates a poor prognosis. Hematopoietic stem cell transplantation can prolong the disease-free survival rate of patients with AML positive for DEK/CAN fusion gene, and the development of new drugs is still one of the hotspots of clinical research. Herein, we reported the first case with DEK/CAN-positive AML who achieved complete remission of molecular biology via decitabine combined with a medium-dose cytarabine regimen. The patient has received three courses of intensive treatment with decitabine combined with medium-dose cytarabine regimen and maintain complete remission of molecular biology for up to 11 months. We hypothesized that the combination of decitabine and medium-dose cytarabine play an important role in targeting DEK/CAN and it should be verified by the accumulation of clinical cases and basic experiments in the future.An increasing number of anaplastic lymphoma kinase (ALK) gene fusion variants have been reported with the popularity of next-generation sequencing (NGS), such as striatin gene (STRN)-ALK, EMAP like 4 (EML4)-ALK and S1 RNA binding domain 1 (SRBD1)-ALK. The clinical outcomes of nonsmall cell lung cancer (NSCLC) patients improved dramatically with the treatment of tyrosine kinase inhibitors (TKIs), but responses to ALK-TKIs differ even for the same fusion variants with different breakpoints. The clinical effectiveness of ALK-TKIs on a new fusion variant needs to be evaluated. Here, we report a case of a lung adenocarcinoma patient, a 70-year-old nonsmoking Chinese man, with rare ALK rearrangement form of, namely, a kinesin family member 5B (KIF5B)-ALK (K20A20) fusion which was identified in tissue by capture-based NGS. The patient achieved a partial response (PR) after treatment with crizotinib. Additionally, an ALK L1196M mutation was detected when the disease progressed after 11 months and was indicated to be sensitive to ceritinib. As far as we know, this is the first report showing that KIF5B-ALK (K20A20) is a fusion variant that is sensitive to crizotinib. We provided a treatment strategy for managing NSCLC patients with KIF5B-ALK (K20A20) fusion or ALK L1196M mutation after crizotinib resistance. Additionally, dynamic genomic analysis of ALK-TKIs treatments is important.Merkel cell carcinoma is a rare type of highly aggressive cutaneous malignant neuroendocrine tumor. YM155 supplier The incidence of Merkel cell carcinomas is higher in organ transplant recipients than healthy controls. There are some reports of Merkel cell carcinomas after kidney transplantation, but few reports of Merkel cell carcinomas after liver transplantation are available. We present a 64-year-old Chinese woman with an asymptomatic nodule on her right tibia 6 years after liver transplantation. The nodule appeared as a purulent scab on the surface and measured 2.4×2.5 cm in diameter. Histopathologic and immunohistochemistry examinations confirmed the nodule to be a Merkel cell carcinoma. No residual Merkel cell carcinoma was detected at the surgical margins after surgical resection. No metastases were detected in a sentinel lymph node biopsy specimen. The wound was suctioned with negative pressure. The patient had an uneventful recovery and was discharged 16 days after surgery. Then, she underwent postsurgical adjuvant radiotherapy. No relapse was observed for approximately 24 months of follow-up. Merkel cell carcinoma may severely impact health, especially among transplant recipients. Immunosuppressants that must be administered after transplantation can increase the risk of Merkel cell carcinoma and physicians should be aware of Merkel cell carcinomas occurring in liver transplant recipients.In view of the high morbidity to complete lymphadenectomy, the sentinel node procedure is currently being investigated in different cancers with the aim of reducing morbidity and of achieving oncological outcomes similar to complete lymphadenectomy. In this review, a parallel will be drawn between the evolutions of the place of lymph node surgery in the management of melanoma and gynecologic cancers. Currently, in the case of cutaneous melanoma, the indications of lymph node surgery are becoming increasingly rare. In contrast with the scarce available evidence in gynecologic cancer, this trend is supported by multicenter randomized studies with a large number of patients for cutaneous melanoma. The second difference is the demonstrated therapeutic benefit of immunotherapies and targeted therapies in cutaneous melanoma, which are less significant in gynecological cancers for which the mainstay of treatment is surgery. According to this review, it seems that in gynecologic oncology, we could in the next decades follow the same pathway currently taken in the management of lymph nodes in malignant melanoma.Single-atom catalysts (SACs) prepared by the atom trapping method often possess high stability yet have limited advantages regarding catalytic performance due to the strong metal-support interaction. Using these SACs as seeds to develop supported nanoclusters or nanoparticles has, however, been proven to be effective in improving the catalysts' intrinsic activity. Herein, we have prepared extremely stable Ir SACs supported by MgAl2O4 via atomic trapping and used them as seeds to fabricate highly active and stable Ir nanocluster catalysts by high-temperature reduction. The activity toward N2O decomposition increased by more than ten times compared with that of the parent Ir SACs. This study provides a new avenue to design and develop highly active and stable catalysts for industrial use.We study the impact of the induced pressure fields on the water flow and salt rejection in nanopores produced in MoS2 membranes. We observe that the water permeability and the salt rejection are not impacted by the distance between the pores. This result contradicts the continuous fluid mechanics calculations in microfilters, which indicates the existence of hydrodynamic interactions between adjacent pores that increase the water mobility. Our results suggest that at this nanoscale, the hydrodynamic interactions do not affect the water mobility through nanopores.Quantum chemistry simulations of some industrially relevant molecules are reported, employing variational quantum algorithms for near-term quantum devices. The energies and dipole moments are calculated along the dissociation curves for lithium hydride (LiH), hydrogen sulfide, lithium hydrogen sulfide, and lithium sulfide. In all cases, we focus on the breaking of a single bond to obtain information about the stability of the molecular species being investigated. We calculate energies and a variety of electrostatic properties of these molecules using classical simulators of quantum devices, with up to 21 qubits for lithium sulfide. Moreover, we calculate the ground-state energy and dipole moment along the dissociation pathway of LiH using IBM quantum devices. This is the first example, to the best of our knowledge, of dipole moment calculations being performed on quantum hardware.Classical molecular dynamics simulations of glassy materials rely on the availability of accurate yet computationally efficient interatomic force fields. The parameterization of new potentials remains challenging due to the non-convex nature of the accompanying optimization problem, which renders the traditional optimization methods inefficient or subject to bias. In this study, we present a new parameterization method based on particle swarm optimization (PSO), which is a stochastic population-based optimization method. Using glassy silica as a case study, we introduce two interatomic potentials using PSO, which are parameterized so as to match structural features obtained from ab initio simulations and experimental neutron diffraction data. We find that the PSO algorithm is highly efficient at searching for and identifying viable potential parameters that reproduce the structural features used as the target in the parameterization. The presented approach is very general and can be easily applied to other interatomic potential parameterization schemes.We present an efficient implementation of periodic Gaussian density fitting (GDF) using the Coulomb metric. The three-center integrals are divided into two parts by range-separating the Coulomb kernel, with the short-range part evaluated in real space and the long-range part in reciprocal space. With a few algorithmic optimizations, we show that this new method-which we call range-separated GDF (RSGDF)-scales sublinearly to linearly with the number of k-points for small to medium-sized k-point meshes that are commonly used in periodic calculations with electron correlation. Numerical results on a few three-dimensional solids show about ten-fold speedups over the previously developed GDF with little precision loss. The error introduced by RSGDF is about 10-5Eh in the converged Hartree-Fock energy with default auxiliary basis sets and can be systematically reduced by increasing the size of the auxiliary basis with little extra work.The role of the support in tuning the properties of transition metal (TM) atoms is studied by means of density functional theory calculations. We have considered the adsorption of Cu, Ag, Au, Ni, Pd, and Pt atoms on crystalline silica bilayers, either free-standing or supported on Ru(0001) and Pt(111) metal surfaces. These systems have been compared with an hydroxylated SiO2/Si(100) film simulating the native oxide formed on a silicon wafer. The properties of the TM atoms change significantly on the various supports. While the unsupported silica bilayer weakly binds some of the TM atoms studied, the SiO2/Ru(0001) or SiO2/Pt(111) supports exhibit enhanced reactivity, sometimes resulting in a net electron transfer with the formation of charged species. Differences in the behavior of SiO2/Ru(0001) and SiO2/Pt(111) are rationalized in terms of different work functions and metal/oxide interfacial distances. No electron transfer is observed on the SiO2/Si(100) films. Here, the presence of hydroxyl groups on the surface provides relatively strong binding sites for the TM atoms that can be stabilized by the interaction with one or two OH groups. The final aspect that has been investigated is the porosity of the silica bilayer, at variance with the dense SiO2/Si(100) film. Depending on the atomic size, some TM atoms can penetrate spontaneously through the six-membered silica rings and become stabilized in the pores of the bilayer or at the SiO2/metal interface. This study shows how very different chemical properties can be obtained by depositing the same TM atom on different silica supports.The accurate description of biradical systems, and in particular the resolution of their singlet-triplet gaps, has long posed a major challenge to the development of electronic structure theories. Biradicaloid singlet ground states are often marked by strong correlation and, hence, may not be accurately treated by mainstream, single-reference methods such as density functional theory or coupled cluster theory. The anti-Hermitian contracted Schrödinger equation (ACSE), whose fundamental quantity is the two-electron reduced density matrix rather than the N-electron wave function, has previously been shown to account for both dynamic and strong correlations when seeded with a strongly correlated guess from a complete active space (CAS) calculation. Here, we develop a spin-averaged implementation of the ACSE, allowing it to treat higher multiplicity states from the CAS input without additional state preparation. We apply the spin-averaged ACSE to calculate the singlet-triplet gaps in a set of small main group biradicaloids, as well as the organic four-electron biradicals trimethylenemethane and cyclobutadiene, and naphthalene, benchmarking the results against other state-of-the-art methods reported in the literature.