Borrebishop6537

The flash sintering behavior of yttria-stabilized zirconia/alumina composites was investigated to understand the role of the fundamental processing and testing parameters (electric field intensity, electric current limit, thermal insulation, homogeneity and dispersion of the two phases) on densification. A strong relation between the composite compositions and the electric parameters needed to promote flash sintering is revealed. Interestingly, the composite preparation method, which affects the two-phases dispersion homogeneity, was shown to have a relevant effect on the flash onset conditions, where the more homogeneous material is more difficult to be flashed. Moreover, the use of a simple thermal insulation system around the green body allowed to improve the final density of the composites under constant electric current.Structural health monitoring is of great significance to ensure the safety of marine pipes, while powering the required monitoring sensors remains a problem because the ocean environment is not amenable to the traditional ways of providing an external power supply. However, mechanical energy due to the vortex-induced vibration of pipelines may be harvested to power those sensors, which is a convenient, economic and environmentally friendly way. We here exploit a contact-separation mode triboelectric nanogenerator (TENG) to create an efficient energy harvester to transform the mechanical energy of vibrating pipes into electrical energy. The TENG device is composed of a tribo-pair of dielectric material films that is connected to a mass-spring base to guarantee the contact-separation motions of the tribo-pair. Experimental tests are conducted to demonstrate the output performance and long-term durability of the TENG device by attaching it to a sample pipe. A theoretical model for the energy harvesting system is developed for predicting the electrical output performance of the device. It is established that the normalized output power depends only on two compound variables with all typical factors taken into consideration simultaneously. The simple scale law is useful to reveal the underlying mechanism of the device and can guideline the optimization of the device based on multi-parameters analyses. The results here may provide references for designing contact-mode TENG energy harvesting devices based on the vibration of marine pipes and similar structures.α-Lipoic acid (ALA) and its reduced form dihydrolipoic acid (DHLA) are endogenous dithiol compounds with significant antioxidant properties, both of which have the potential to detoxify cells. In this study, ALA (250 μM) and DHLA (50 μM) were applied to reduce metal (As, Cd, and Pb)-induced toxicity in PC12 and Caco-2 cells as simultaneous exposure. Both significantly decreased Cd (5 μM)-, As (5 μM)-, and Pb (5 μM)-induced cell death. Subsequently, both ALA and DHLA restored cell membrane integrity and intracellular glutathione (GSH) levels, which were affected by metal-induced toxicity. In addition, DHLA protected PC12 cells from metal-induced DNA damage upon co-exposure to metals. Furthermore, ALA and DHLA upregulated the expression of survival-related proteins mTOR (mammalian target of rapamycin), Akt (protein kinase B), and Nrf2 (nuclear factor erythroid 2-related factor 2) in PC12 cells, which were previously downregulated by metal exposure. In contrast, in Caco-2 cells, upon co-exposure to metals and ALA, Nrf2 was upregulated and cleaved PARP-1 (poly (ADP-ribose) polymerase-1) was downregulated. These findings suggest that ALA and DHLA can counterbalance the toxic effects of metals. The protection of ALA or DHLA against metal toxicity may be largely due to an enhancement of antioxidant defense along with reduced glutathione level, which ultimately reduces the cellular oxidative stress.Sphingosine-1-phosphate (S1P), is a signaling sphingolipid which acts as a bioactive lipid mediator. We assessed whether S1P had multiplex effects in regulating the large-conductance Ca2+-activated K+ channel (BKCa) in catecholamine-secreting chromaffin cells. Using multiple patch-clamp modes, Ca2+ imaging, and computational modeling, we evaluated the effects of S1P on the Ca2+-activated K+ currents (IK(Ca)) in bovine adrenal chromaffin cells and in a pheochromocytoma cell line (PC12). In outside-out patches, the open probability of BKCa channel was reduced with a mean-closed time increment, but without a conductance change in response to a low-concentration S1P (1 µM). The intracellular Ca2+ concentration (Cai) was elevated in response to a high-dose (10 µM) but not low-dose of S1P. check details The single-channel activity of BKCa was also enhanced by S1P (10 µM) in the cell-attached recording of chromaffin cells. In the whole-cell voltage-clamp, a low-dose S1P (1 µM) suppressed IK(Ca), whereas a high-dose S1P (10 µM) produced a biphasic response in the amplitude of IK(Ca), i.e., an initial decrease followed by a sustained increase. The S1P-induced IK(Ca) enhancement was abolished by BAPTA. Current-clamp studies showed that S1P (1 µM) increased the action potential (AP) firing. Simulation data revealed that the decreased BKCa conductance leads to increased AP firings in a modeling chromaffin cell. Over a similar dosage range, S1P (1 µM) inhibited IK(Ca) and the permissive role of S1P on the BKCa activity was also effectively observed in the PC12 cell system. The S1P-mediated IK(Ca) stimulation may result from the elevated Cai, whereas the inhibition of BKCa activity by S1P appears to be direct. By the differentiated tailoring BKCa channel function, S1P can modulate stimulus-secretion coupling in chromaffin cells.The Sustainable Development Goals (SDGs) is a global strategy that aims to obtain a more equitable and just world. These objectives are organized into 17 SDGs, detailing 169 targets. Different international institutions have emphasized the relevance of education to developing citizens who contribute to achieving the SDGs for 2030. However, a review focused on physical education (PE) has yet to be performed. Therefore, the objective of this work is two-fold. First, to analyze and select the specific SDGs that can be implemented in the area of physical education. Second, to relate these specific goals to the different models based on physical education practices. This review showed how three institutional documents have previously related sport, physical exercise, and physical education to specific SDGs. Based on the search done, this review article selects those goals that could be integrated into the educational context through physical education. The bibliographic and critical analysis in this research shows that of the 169 specific goals proposed in the SDGs, only 24 could be worked on in physical education.