Borkipsen6687
The review provides scientific data on modern aspects of using the kinesiotaping method in neurological patients. Possible clinical taping methods for myofascial pain and post-traumatic disorders of the musculoskeletal system are considered. The important role in the correction of biomechanical disorders and the rehabilitation potential of the taping method in the treatment and prevention of musculoskeletal pathology has been demonstrated. Experimental and clinical studies of Russian and foreign scientists are presented, indicating the promise of therapeutic and preventive possibilities of kinesiotaping. Conclusions are made about the advisability of using kinesiotaping in an interdisciplinary approach in the treatment of patients with neurological disorders.Siponimod is a selective modulator of sphingosine-1-phosphate (S1P) receptors of types 1 and 5, registered in the Russian Federation for the treatment of patients with secondary progressive multiple sclerosis (SPMS), regardless of the presence or absence of exacerbations. The effectiveness of the drug in comparison with placebo was demonstrated in patients with SPMS in the international clinical trial EXPAND (phase III). This review devotes actual problems in the treatment of patients with SPMS, discusses the pathophysiology of multiple sclerosis progression, describes the peripheral and central mechanisms of siponimod action and its differences from fingolimod. According to analysis of scientific literature experimental, clinical and neuroimaging data are presented, which could explain the reasons for the successful use of siponimod in patients with SPMS, taking into account the pathophysiological mechanisms of the development of progression and the mechanisms of drug action.The review of publications on functional magnetic resonance imaging (fMRI) and its practical application in neurosurgery is presented. Advantages and disadvantages are selected taking pathogenesis into account. Results of surgical treatment with use of functional navigation are described. Separate attention is paid to fMRI precision by its comparing with direct cortical stimulation. New resting-state method of visualization is observed. Practical advices are given of fMRI application in neurooncology and surgery of arteriovenous malformations.Hemiplegic migraine (HM) is a rare subtype of migraine with aura which prevalence is about 0.01%. The characteristic features include motor symptoms (hemiparesis) along with the signs of migraine with typical aura (visual, sensory and/or speech disturbances). The diagnosis of familial hemiplegic migraine (FHM) is established when at least 1 or more relatives of the 1st or 2nd degree in the family have the attacks of HM. This report describes a family in which two members (father and daughter) develop attacks of severe headache with nausea and, sometimes, vomiting, accompanied by visual disturbances, speech impairment, followed by unilateral numbness and weakness of extremities. The diagnosis of FHM was established. The report includes the review of literature and the discussion of some aspects of differential diagnosis.The concept of psychopathic personalities presented in the 8-th last lifetime edition of E. Kraepelin's textbook is analyzed. The special interest was guided by the fact that many types of psychopathic personalities were described by E. Kraepelin in other rubrics «primary morbid states», manic-depressive illness, paranoia, hysteria, Dementia praecox. E. Kraepelin gave also a prognosis of further development of psychopathic personality and by this way analyzed its dynamics. So, for example, he found that the prognosis of unstable personalities is less favorable compared to those with excitable type. E. Kraepelin subdivided the types of «liars and swindlers», "antisocial" and also hysterics according to the prognosis in stationary and regredient courses. The regredient course of psychopathy E. check details Kraepelin explained by behindhand maturing of psychopathic traits caused by partial infantilism. Constitutionally depressed, constitutionally excited, irritable and cyclothymic psychopathic types distinguished by their disposition to phasic manifesting affective disorders (MDP), but were capable also to remain stationary during the lifetime as the corresponding three types of psychopathic personalities delineated by E. Kraepelin in schizophrenia. The type of «nervous» (from the rubric of «primary morbid states») was the ground for obsessive-compulsive neurosis, sexual perversions and also was able to combine with more or less prominent traits of other psychopathic types. According to clinical features, the «nervous» type was the expression of the conceptually preceding notion of general «degenerative constitution». It is important to note that E. Kraepelin considered the possibilities of combinations of different psychopathic types (connections of psychopathic traits) but never considered the possibility of development from one innate psychopathic type in the other.
To present clinical and epidemiological aspects of neuromyelitis optica spectrum disorders (NMOSD) in the Russian Federation.
We studied 142 patients who met diagnostic criteria of 2015 for NMOSD. Sex, age at disease onset, presence or absence of aquaporin-4 immunoglobulin G antibodies (AQP4-IgG), mail clinical symptoms, oligoclonal IgG, therapy for the treatment of exacerbations and prevention of exacerbations, compliance with 2006 diagnostic criteria were assessed.
The prevalence of women is 4.261, the most frequent age at disease onset is 18-29 years (36% of cases). The laboratory aspects of the disease are characterized and approaches to the treatment and prevention of exacerbations of NMOSD in patients of the Russian population are evaluated. Approaches to diagnostics are compared depending on the applied diagnostic criteria (34% of patients do not meet neuromyelitis optica 2006 diagnostic criteria). A prognosis for the prevalence of NMOSD in the Russian population has been proposed 0.45-4.21/100000.
This is the first published data on clinical and epidemiological characteristics of NMOSD in the Russian Federation.
This is the first published data on clinical and epidemiological characteristics of NMOSD in the Russian Federation.
The results of the analysis of psychopathological symptom dynamics during the COVID-19 pandemic in Russia are presented.
The study uses the data of the Internet survey, which included a block of sociodemographic questions and the SCL-90-R symptomatic questionnaire. Nine hundred and eight responses received from 22.03.20 to 22.06.20 were analysed. The change in the responses over time was assessed 3 periods of time were allocated, associated with the change in countermeasures to the pandemic in Russia. In addition, the change in the values of the SCL-90 parameters was assessed depending on the existence of respondent's acquaintances infected with the coronavirus.
It was shown that SCL-90 symptoms (Somatization, Depression, Obsession, all integral parameters, including the Global Severity Index) increased from 22.03.20 to 22.06.20. With infected people appearing in the respondent's environment psychopathological symptoms increase. The growth of hostility, sensitivity and anxiety is associated with a personal experience of a danger of the pandemic, which intensifies when infected persons appear in the immediate environment.
The increase in psychopathological symptoms after the mitigation or cancellation of the quarantine restrictions suggests the persistence of long-term consequences.
The increase in psychopathological symptoms after the mitigation or cancellation of the quarantine restrictions suggests the persistence of long-term consequences.
To compare the antioxidant effects of cortexin, cerebrolysin and actovegin in rats with chronic brain ischemia.
Chronic brain ischemia was modeled in male rats by 50% stenosis of the common carotid arteries. Forty days after surgery, the animals received 2 ten-day courses of therapy, separated by a break of 10 days. Placebo, cortexin (0.3, 1 and 3 mg/kg), cerebrolysin (0.8, 2.5 and 7.5 ml/kg) and actovegin (5 ml/kg) were administered to animals as treatment. The concentration of malondialdehyde (MDA) in the homogenates was determined by the reaction with thiobarbituric acid, the concentration of reduced glutathione was determined by the reduction reaction of 5.5-dithiobis- (2-nitrobenzoic acid); determination of catalase activity, as well as the content of lactate and pyruvate, by commercially available reagent kits. The activity of superoxide dismutase (SOD) was determined by the photometric method based on an assessment of the degree of inhibition of the epinephrine oxidation reaction. All reactions werats with chronic brain ischemia.
Course administration of cortexin (3 mg/kg), cerebrolysin (7.5 ml/kg) and, to a lesser extent, actovegin (5 ml/kg) has a positive effect on the state of the antioxidant system of the brain in rats with chronic brain ischemia.
To study was to test an associations of the preliminary genetic risk markers for Internet addiction (IA) with clinical, psychological and personality characteristics, taking into account the childhood traumatic experience, in 44 IA persons compared with 120 healthy individuals.
The study included 164 participants 44 individuals with IZ (group IZ), male and female, aged 16 to 30 years in the absence of diagnoses of mental health problems. diseases from rubrics F00-09 and F20-29 (ICD-10) and 120 healthy (control group).
We have found an associations of the preliminary IA genetic risk markers with some personality traits and behavioral characteristics (TCI-125, TIPI) and with the childhood trauma experience (ACE IQ, CTQ), both for healthy individuals and to a greater extent for IA individuals, that may suggests the possible effects of the gene-environment interaction on a risk of developing IA. The data obtained on the structure of associations between IA genetic risk markers and individual psychological characteristics under the significant influence of the childhood trauma experience allow us to proceed with the construction of models for IA risk prediction taking into account the "gene - environment" interactions.
We have found an associations of the preliminary IA genetic risk markers with some personality traits and behavioral characteristics (TCI-125, TIPI) and with the childhood trauma experience (ACE IQ, CTQ), both for healthy individuals and to a greater extent for IA individuals, that may suggests the possible effects of the gene-environment interaction on a risk of developing IA. The data obtained on the structure of associations between IA genetic risk markers and individual psychological characteristics under the significant influence of the childhood trauma experience allow us to proceed with the construction of models for IA risk prediction taking into account the "gene - environment" interactions.
To compare the groups of schizophrenic patients with different levels of functional outcome and different frequency of risk variants in polymorphic loci of five candidate genes to create a multigene panel and to test its predictive ability for long-term outcome of the disease.
According to the proposed typology, the patients included in the studies were divided into three groups, which differed in the level of social functioning. Group 1 was characterized by the highest level, in group 2 this indicator was significantly lower, and in group 3 the lowest. The multigenic panel included genes for serotonin receptor type 2a (5-HTR2A T102C), serotonin transporter (5-HTTLPR), C-reactive protein (CRP -717A>G), angiotensin II receptor type 1 (AGTR1 A1166C), and brain neurotrophic factor (BDNF Val66Met). A multi-gene risk score was calculated for each patient by summing the total number all his/her risk alleles. For each polymorphism, a score of 2 was assigned to homozygous high-risk genotypes, a score of 1 to heterozygous genotypes and a score of 0 to homozygous low-risk genotype.
