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Appropriate orthopedic force led to bone remodeling of mandibular condyle, while overloaded orthopedic force (OOF) induced condylar bone absorption. Bone absorption is ascribed to the imbalanced activities between osteoclasts (OCs) and osteoblasts (OBs), mechanism of which remains unclear. This study aimed to observe the condylar changes induced by OOF by mandible advancement appliance and to further investigate the role of mammalian target of Rapamycin (mTOR) and RANKL/OPG in osteoclastic differentiation of stem cells in vivo and in vitro. In vivo, the results of micro-CT analysis indicated that condylar bone resorption was induced by OOF through mandibular advancement appliance for 2 weeks and worsened time dependently. Morphologically, cartilage thickness was reduced, subchondral cortical bone line appeared not continuous, and subchondral bone exhibited irregular-shaped and owned uneven surface. The bone mineral density (BMD), bone volume/tissue volume (BV/TV), trabecular number (Tb.N), and trabecular thic OOF and were involved in promoting MSCs differentiating into OCs.Semantic transparency has been extensively analysed in research on visual word recognition. Under the masked priming paradigm, it has consistently been shown that opaque and transparent words are facilitated relative to form-related controls, but differences in priming between one condition and another have not been conclusively proven. Hence, research has been unable to theoretically elucidate the possible value of semantic transparency in the processing of derived words. This study describes two lexical decision experiments in Spanish. Experiment 1 revealed differences between the transparent and orthographic conditions, with no differences between the other conditions in the analyses of the error rates. In the second experiment, the participants visited the laboratory on two occasions, separated by a week. The task was administered twice, with participants responding to one of the experimental lists on each day. The results of this second experiment revealed significant differences in the size of the priming effect of the opaque and transparent conditions compared with the form-related condition, but without differences between these two effects. We discuss these findings from the perspective of current models of visual lexical processing.Cognitive control can adapt to the level of conflict present in the environment in a proactive (pre-stimulus onset) or reactive (post-stimulus onset) manner. This is evidenced by list-wide and location-specific proportion congruence effects, reduced interference in higher conflict lists or locations, respectively. Proactive control in the flanker task is believed to be supported by a conflict-induced-filtering (CIF) mechanism. The goal of the present set of experiments was to test if CIF also supports reactive location-specific control in the flanker task. To measure CIF, we interspersed a visual search task with a flanker task. After reproducing evidence for CIF using a two-location, list-wide proportion congruence manipulation (Experiment 1), we examined if a similar pattern emerges using a location-specific proportion congruence manipulation in Experiments 2 - 5. We found minimal evidence that reactive location-specific control employs a CIF mechanism. What was clear, however, is that the location-specific proportion congruence effect is susceptible to disruption from an intermixed task that dilutes the location-conflict signal. This highlights the need for alternative approaches to elucidate whether CIF or another mechanism supports reactive, location-specific control.Across seven experiments, the present article examined the influence of the number of part-set cues on order retention, as assessed by both reconstruction of order and serial recall tests. Historically, part-set cueing facilitation occurs when half of the items are provided as valid part-set cues on tests of order memory. Using a variety of list lengths (10 or 16), numbers of cues (0-14), and types of cues (full or partial), the present experiments showed disparate effects of the number of part-set cues on reconstruction and serial recall tasks. On reconstruction tests, a minimum number of full cues was required before part-set cueing facilitation was produced and the magnitude of facilitation increased as the number of cues increased. Generally, partial cues did not influence order retention until almost the entire list was provided as partial cues. On serial recall tests, part-set cueing facilitation was only evident with a few full cues. In contrast, part-set cueing impairment was the norm when many partial cues were provided. These results were largely consistent with predictions of the retrieval strategy disruption hypothesis, as well as with an anchoring account of part-set cueing for order.Frisson is characterised by tingling and tickling sensations with positive or negative feelings. selleckchem However, it is still unknown what factors affect the intensity of frisson. We conducted experiments on the stimulus characteristics and individual's mood states and personality traits. Participants filled out self-reported questionnaires, including the Profile of Mood States, Beck Depression Inventory, and Big Five Inventory. They continuously indicated the subjective intensity of frisson throughout a 17-min experiment while listening to binaural brushing and tapping sounds through headphones. In the interviews after the experiments, participants reported that tingling and tickling sensations mainly originated on their ears, neck, shoulders, and back. Cross-correlation results showed that the intensity of frisson was closely linked to the acoustic features of auditory stimuli, including their amplitude, spectral centroid, and spectral bandwidth. This suggests that proximal sounds with dark and compact timbre trigger frisson. The peak of correlation between frisson and the acoustic feature was observed 2 s after the acoustic feature changed, suggesting that bottom-up auditory inputs modulate skin-related modalities. We also found that participants with anxiety were sensitive to frisson. Our results provide important clues to understanding the mechanisms of auditory-somatosensory interactions.