Berntsenlyhne1485

g. small molecules, protein, DNA and so on). © 2020 The Authors.In fully mechanized caving mining of extra-thick coal seams, the movement range of overburden is wide, resulting in the breakage of multilayer hard roofs in overlying large spaces. However, the characteristics, morphology and impact effect of hard roofs at different levels are different and unclear. In this study, a secondary development was used in the numerical simulation software ABAQUS, and the caving of rock strata in the finite-element software was realized. The bearing stress distribution, fracturing morphology and impact energy characteristics of hard roofs at different levels were studied to reflect the action and difference of hard roof failure on the working face; thus, revealing the mechanism of the strong ground pressure in stopes, and providing a theoretical basis for the safe and efficient mining of extra-thick coal seams with hard roofs. © 2020 The Authors.A computational model has been developed to predict the role of environment in the forms and functions of termite mounds. The proposed model considers the most relevant forces involved in the heat transfer process of termite mounds, while also reflecting their gas-exchange function. The method adopts a system configuration procedure to determine thermally optimized mound structures. The model successfully predicts the main architectural characteristics of typical Macrotermes michaelseni mounds for the environmental conditions they live in. The results indicate that the mound superstructure and internal condition strongly depend on the combined effect of environmental forces. It is noted that mounds being exposed to higher solar irradiances develop intricate lateral channels, inside, and taller and more pronounced spire tilt towards the Sun, outside. It is also found that the mounds' spire tilt angle depends on the geographical location, following the local average solar zenith angle for strong irradiances. Although wind does not influence the overall over-ground mound shape, it significantly affects the mound internal condition. The results of this study resonate with what is seen in nature. The proposed approach provides a broader view of the factors that are effective in the form and function of a naturally made structure. © 2020 The Authors.Both tetrahydroisoquinolines (THIQs) and oxindoles (OXs) display a broad range of biological activities including anti-cancer activity, and are therefore recognized as two privileged scaffolds in drug discovery. In the present study, 24 3',4'-dihydro-2'H-spiro[indoline-3,1'-isoquinolin]-2-ones, designed as molecular hybrids of THIQ and OX, were synthesized and screened in vitro against 59 cell lines in the NCI-60 screen. Twenty compounds displayed weak to moderate inhibition of cell proliferation; among them, three compounds displayed at least 50% inhibition of cell proliferation. The compounds appeared to target primarily renal cell cancer lines; however, leukaemia, melanoma, non-small cell lung cancer, prostate, ovarian and even breast cancer cell lines were also affected. Therefore, this class of spirooxindoles may provide useful leads in the search for new anti-cancer agents. © 2020 The Authors.The polymer solution for oil displacement is subjected to strong shear action in practical application, and this action will affect its percolation characteristics in porous media. The effects of mechanical shearing on the solution properties and seepage characteristics of modified hydrophobically associated polymers and dendrimers with two different aggregation behaviours were studied. The results showed that mechanical shearing did not affect hydrophobic microzones. Decursin order Polymers can re-associate to restore part of the network structure, thereby improving shear resistance (dendritic hydrophobically associating polymers > hydrophobically modified partially hydrolysed polyacrylamide). Polymers with 'cluster' aggregation behaviour enhanced solution performance, enabling them to establish higher resistance coefficient (RF) and residual resistance factor (RRF) in porous media but also bringing about injection difficulties. Increasing the injection rate would increase the injection pressure, but the established RF and RRF showed a downward trend. Mechanical shear pretreatment effectively improved the injectability of the polymer. To achieve polymer injection and flow control, pre-shearing polymer solution and low-speed injection can be used in field applications. © 2020 The Authors.Background The polyproline II helix (PPIIH) is an extended protein left-handed secondary structure that usually but not necessarily involves prolines. Short PPIIHs are frequently, but not exclusively, found in disordered protein regions, where they may interact with peptide-binding domains. However, no readily usable software is available to predict this state. Results We developed PPIIPRED to predict polyproline II helix secondary structure from protein sequences, using bidirectional recurrent neural networks trained on known three-dimensional structures with dihedral angle filtering. The performance of the method was evaluated in an external validation set. In addition to proline, PPIIPRED favours amino acids whose side chains extend from the backbone (Leu, Met, Lys, Arg, Glu, Gln), as well as Ala and Val. Utility for individual residue predictions is restricted by the rarity of the PPIIH feature compared to structurally common features. Conclusion The software, available at http//bioware.ucd.ie/PPIIPRED, is useful in large-scale studies, such as evolutionary analyses of PPIIH, or computationally reducing large datasets of candidate binding peptides for further experimental validation. © 2020 The Authors.This study illustrated the growth of Scenedesmus obliquus and recycle of nutrients in wastewater combined with inorganic carbon under autotrophic conditions. Scenedesmus obliquus was cultivated under different conditions by adding sodium carbonate (Na2CO3) at 15-40 mg l-1 separately in wastewater containing high nitrogen and phosphorus content. The growth characteristics of S. obliquus, pH and dissolved inorganic carbon (DIC) changes of microalgae liquid, the recycle rate of ammonia and phosphorus and lipid content were determined. The changes of pH and DIC showed that S. obliquus could use Na2CO3 to grow, with lipid contents of 18-25%. Among all Na2CO3 concentrations, 20 mg l-1 was the optimum, of which S. obliquus had the highest NH3-N recycle of 52% and P O 4 3 - P recycle of 67%. By the 14th day, its biomass production also reaches the maximum of 0.21 g l-1. However, inorganic carbon fixation rate was inversely proportional to its concentration. Moreover, the biomass was in positive correlation with the Na2CO3 concentration except 20 mg l-1, which provided a possibility that S.