Bendergissel0887

Cardiovascular diseases are one of the leading global causes of death. Following the positive experiences with machine learning in medicine we performed a study in which we assessed how machine learning can support decision making regarding coronary artery diseases. While a plethora of studies reported high accuracy rates of machine learning algorithms (MLA) in medical applications, the majority of the studies used the cleansed medical data bases without the presence of the "real world noise." Contrary, the aim of our study was to perform machine learning on the routinely collected Anonymous Cardiovascular Database (ACD), extracted directly from a hospital information system of the University Medical Centre Maribor). Many studies used tens of different machine learning approaches with substantially varying results regarding accuracy (ACU), hence they were not usable as a base to validate the results of our study. Thus, we decided, that our study will be performed in the 2 phases. During the first phase we trained the different MLAs on a comparable University of California Irvine UCI Heart Disease Dataset. The aim of this phase was first to define the "standard" ACU values and second to reduce the set of all MLAs to the most appropriate candidates to be used on the ACD, during the second phase. Seven MLAs were selected and the standard ACUs for the 2-class diagnosis were 0.85. Surprisingly, the same MLAs achieved the ACUs around 0.96 on the ACD. A general comparison of both databases revealed that different machine learning algorithms performance differ significantly. The accuracy on the ACD reached the highest levels using decision trees and neural networks while Liner regression and AdaBoost performed best in UCI database. This might indicate that decision trees based algorithms and neural networks are better in coping with real world not "noise free" clinical data and could successfully support decision making concerned with coronary diseasesmachine learning.

Retrospective cohort study.

Overcorrection in adult spinal deformity (ASD) surgery may lead to proximal junctional kyphosis (PJK) because of posterior spinal displacement. The aim of this paper is to determine if the L1 position relative to the gravity line (GL) is associated with PJK.

ASD patients fused from the lower thoracic spine to sacrum by 4 spine surgeons at our hospital were retrospectively studied. Lumbar-only and upper thoracic spine fusions were excluded. Spinopelvic parameters, the L1 plumb line (L1PL), L1 distance to the GL (L1-GL), and Roussouly type were measured.

One hundred fourteen patients met inclusion criteria (63 patients with PJK, 51 without). Mean age and follow up was 65.51 and 3.39 years, respectively. There was no difference between the PJK and the non-PJK groups in baseline demographics, pre-operative and immediate post-operative pelvic incidence-lumbar lordosis mismatch, sagittal vertical axis, or coronal Cobb. The immediate postoperative L1-GL was -7.24 cm in PJK and -3.45 cm in non-PJK (

< 0.001), L1PL was 1.71 cm in PJK and 3.07 cm in non-PJK (

= 0.004), and PT (23.76° vs 18.90°,

= 0.026) and TK (40.56° vs 31.39°,

< 0.001) were larger in PJK than in non-PJK. After univariate and multivariate analyses, immediate postoperative TK and immediate postoperative L1-GL were independent risk factors for PJK without collinearity.

A dorsally displaced L1 relative to the GL was associated with an increased risk of PJK after ASD surgery. The postoperative L1-GL distance may be a factor to consider during ASD surgery.

A dorsally displaced L1 relative to the GL was associated with an increased risk of PJK after ASD surgery. The postoperative L1-GL distance may be a factor to consider during ASD surgery.The transposed brachiobasilic arteriovenous fistula is often constructed by employing a two-stage procedure for better maturation and long-term patency, but its validity on overall outcomes remains controversial. A single-center's experience is presented herein, comparing one- and two-stage approaches on 229 consecutive first-time arteriovenous access constructed in the upper arm with a loop configuration and an obtuse anastomosis angle that provide favorable flow dynamics. The one- and two-year patency rates were equivalent between the two approaches, but the fistula rate was greater and the maturation time was shorter with the one-stage procedure.

To review data of elagolix plus estradiol and norethindrone acetate as add-back therapy for the treatment of heavy menstrual bleeding (HMB) in premenopausal women with uterine fibroids.

Literature search of PubMed/MEDLINE and SCOPUS was performed using the search terms

and

between January 1, 1996, to March 2, 2021. Additional data were obtained from prescribing information, references of identified articles, and abstracts from scientific meetings.

Clinical trials and articles discussing elagolix plus add-back therapy for the management of HMB in women with leiomyomas were included.

Phase 3 trials met the primary end point of menstrual blood loss (MBL) less than 80 mL at month 6 and at least a 50% reduction in MBL from baseline to the final month in 68.5% of women taking elagolix plus add-back therapy enrolled in UF-1 (8.7% placebo) and 76.5% of women in UF-2 (10% placebo). The most common adverse effects include hot flushes, nausea, headache, and night sweats.

Women with symptomatic uterine fibroids can experience significant HMB resulting in distress, depression, and anxiety. Surgical intervention remains the most commonly recommended and chosen treatment. Elagolix plus add-back therapy is a nonsurgical, oral option.

Elagolix plus add-back therapy is effective in reducing menstrual bleeding associated with uterine fibroids. However, there are several warnings and precautions that must be considered.

Elagolix plus add-back therapy is effective in reducing menstrual bleeding associated with uterine fibroids. However, there are several warnings and precautions that must be considered.

Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma.

Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis.

All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group (

< 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters (

> 0.05) in the patient group. All biomarkers were positively correlated with each other (

< 0.001).

The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.

The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.Due to COVID-19 a live, in-person meeting was not possible for the American Epilepsy Society in 2020. An alternative, virtual event, the AES2020, was held instead. AES2020 was a great success with 4679 attendees from 70 countries. The educational content was outstanding and spanned the causes, treatments, and outcomes from epileptic encephalopathy to the iatrogenicity of epilepsy interventions to neurocognitive disabilities to the approach to neocortical epilepsies. New gene therapy approaches such as antisense oligonucleotide treatment for Dravet syndrome were introduced and neuromodulation devices were discussed. There were many other topics discussed in special interest groups and investigators' workshops. A highlight was having a Nobel prize winner speak about memory processing. Human intracranial electrophysiology contributes insights into memory processing and complements animal work. In a special COVID symposium, the impact of COVID on patients with epilepsy was reviewed. Telehealth has been expanded rapidly and may be well suited for some parts of epilepsy care. In summary, the epilepsy community was alive and engaged despite being limited to a virtual platform.Paul Gugiu argues that Kaplan and Baron-Epel's central idea or underlying premise is not merely wrong, but "dangerous with potentially dire consequences," particularly in our current circumstances of a pandemic and a polarized political atmosphere. We disagree in the strongest terms and believe that nothing in Kaplan and Baron-Epel's article can be fairly thought to support such a claim. We begin by addressing Gugiu's framing of Kaplan and Baron-Epel's position, before examining his criticisms of that position in turn.

Examine changes in sleep duration by 3 behavioral phenotypes during a workplace wellness program with overweight and obese adults.

Secondary analysis of a randomized clinical trial.

Remotely monitored intervention conducted across the United States.

553 participants with a body mass index ≥25.

Participants were randomized to 1 of 4 study arms control, gamification with support, gamification with collaboration, and gamification with competition to increase their physical activity. All participants were issued a wrist-worn wearable device to record their daily physical activity and sleep duration.

The primary outcome was change in daily sleep duration from baseline during the 24 week intervention and follow-up period by study arm within behavioral phenotype class.

Linear mixed effects regression.

Participants who had a phenotype of less physically active and less social at baseline, in the gamification with collaboration arm, significantly increased their sleep duration during the intervention period (30.2 minutes [95% CI 6.9, 53.5],

= 0.01), compared to the control arm. PI3K inhibitor There were no changes in sleep duration among participants who were more extroverted and motivated or participants who were less motivated and at-risk.

Changes in sleep during a physical activity intervention varied by behavioral phenotype. Behavioral phenotypes may help to precisely identify who is likely to improve sleep duration during a physical activity intervention.

Changes in sleep during a physical activity intervention varied by behavioral phenotype. Behavioral phenotypes may help to precisely identify who is likely to improve sleep duration during a physical activity intervention.Aberrant complement activation leads to tissue damage during kidney transplantation, and it is recognized as an important target for therapeutic intervention. However, it is not clear whether cold storage (CS) triggers the complement pathway in transplanted kidneys. The goal of the present study was to determine the impact of CS on complement activation in renal transplants. Male Lewis and Fischer rats were used, and donor rat kidneys were exposed to 4 h or 18 h of CS followed by transplantation (CS + transplant). To study CS-induced effects, a group with no CS was included in which the kidney was removed and transplanted back to the same rat [autotransplantation (ATx)]. Complement proteins (C3 and C5b-9) were evaluated with Western blot analysis (reducing and nonreducing conditions) and immunostaining. Western blot analysis of renal extracts or serum indicated that the levels of C3 and C5b-9 increased after CS + transplant compared with ATx. Quite strikingly, intracellular C3 was profoundly elevated within renal tubules after CS + transplant but was absent in sham or ATx groups, which showed only extratubular C3.