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Our research demonstrates the potential of using state-of-the-art subseasonal climate forecasts to produce actionable subseasonal dengue predictions. To the best of the authors' knowledge, this is the first time subseasonal forecasts have been used this way.Magnetic Resonance Imaging (MRI) can be used to assess anatomical structure, and its sensitivity to a variety of tissue properties enables superb contrast between tissues as well as the ability to characterize these tissues. However, despite vast potential for quantitative and functional evaluation, MRI is typically used qualitatively, in which the underlying tissue properties are not measured, and thus the brightness of each pixel is not quantitatively meaningful. Positron Emission Tomography (PET) is an inherently quantitative imaging modality that interrogates functional activity within a tissue, probed by a molecule of interest coupled with an appropriate tracer. These modalities can complement one another to provide clinical information regarding both structure and function, but there are still technical and practical hurdles in the way of the integrated use of both modalities. Recent advances in MRI have moved the field in an increasingly quantitative direction, which is complementary to PET, and could also potentially help solve some of the challenges in PET/MR. Magnetic Resonance Fingerprinting (MRF) is a recently described MRI-based technique which can efficiently and simultaneously quantitatively map several tissue properties in a single exam. Here, the basic principles behind the quantitative approach of MRF are laid out, and the potential implications for combined PET/MR are discussed.Wolfram syndrome (WS) is a rare, progressive disorder characterized by childhood-onset diabetes mellitus, optic nerve atrophy, hearing loss, diabetes insipidus, and neurodegeneration. Currently, there is no effective treatment for WS, and patients typically die between 30 and 40 years of age. WS is primarily caused by autosomal recessive mutations in the Wolfram syndrome 1 (WFS1) gene (OMIM 222300), which encodes for wolframin (WFS1). This disorder is therefore a valuable monogenic model for prevalent diseases, particularly diabetes mellitus and neurodegeneration. Whereas reduced survival and secretion are known cellular impairments causing WS, the underlying molecular pathways and the physiological function of WFS1 remain incompletely described. Here, we characterize WFS1 as a regulator of intracellular calcium homeostasis, review our current understanding of the disease mechanism of WS, and discuss candidate treatment approaches. These insights will facilitate identification of new therapeutic strategies not only for WS but also for diabetes mellitus and neurodegeneration.Perceptual decisions are informed by the accumulation of sensory evidence over time, but the form of this fundamental temporal computation is not fully understood. Characterizations of the temporal integration of sensory stimuli in behavior and neural activity are usually conceived with separate stages for sensory encoding and downstream integration for accumulating the sensory evidence. Sensory and decision stages can each have their own temporal dynamics that affect the time course of perception and action. Here, we discuss recent work using temporal signatures of behavior in the context of traditional two-stage models. This discussion highlights shortcomings of two stage sensory/decision frameworks, points towards how modern techniques can provide more realistic characterizations of temporal integration, and in turn motivates a richer philosophical framework for building models of how sensory data might be interpreted by the brain to produce actions.Given the prevalence of sleep in early development, any satisfactory account of infant brain activity must consider what happens during sleep. this website Only recently, however, has it become possible to record sleep-related brain activity in newborn rodents. Using such methods in rat pups, it is now clear that sleep, more so than wake, provides a critical context for the processing of sensory input and the expression of functional connectivity throughout the sensorimotor system. In addition, sleep uniquely reveals functional activity in the developing primary motor cortex, which establishes a somatosensory map long before its role in motor control emerges. These findings will inform our understanding of the developmental processes that contribute to the nascent sense of embodiment in human infants.Diabetes is a major worldwide health problem which results from the loss and/or dysfunction of pancreatic insulin-producing β cells in the pancreas. Therefore, there is great interest in understanding the endogenous capacity of β cells to regenerate under normal or pathological conditions, with the goal of restoring functional β cell mass in patients with diabetes. Here, we summarize the current status of β cell regeneration research, which has been broadly divided into three in vivo mechanisms 1. proliferation of existing β cells; 2. neogenesis of β cells from adult ductal progenitors; and 3. transdifferentiation of other cell types into β cells. We discuss the evidence and controversies for each mechanism in mice and humans, as well as the prospect of using these approaches for the treatment of diabetes.Preterm birth and postpartum hemorrhage are the leading causes of neonatal and maternal morbidities worldwide, respectively. Current clinically utilized tocolytics and uterotonics to manage these obstetric conditions are limited due to their off-target effects and/or lack of efficacy. Thus, an ideal tocolytic or uterotonic would be uterine-selective with rapid onset and long-duration efficacy. Here, we discuss strategies for the discovery of new therapeutic targets and compounds that regulate uterine contractility with the aforementioned properties.Today there are extensive maps of the molecular heterogeneity of primary afferents and dorsal horn interneurons, yet there is a dearth of molecular and functional information regarding the projection neurons that transmit pain and itch information to the brain. Additionally, most contemporary research into the spinal cord and medullary projection neurons focuses on neurons in the superficial dorsal horn; the contribution of deep dorsal horn and even ventral horn projection neurons to pain and itch processing is often overlooked. In the present review we integrate conclusions from classical as well as contemporary studies and provide a more balanced view of the diversity of projection neurons. A major question addressed is the extent to which labeled-lines are maintained in these different populations or whether the brain generates distinct pain and itch percepts by decoding complex convergent inputs that engage projection neurons.