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The massive irruption of Covid-19 expression in the hospital environment as well as in our lives has brought to light a strange analogy between the expansion of a virus and viral dissemination, too, in a way of speaking and naming for action. This article proposes to question the impact of the expression Covid-19 on the language of caregivers. It proposes to discuss the ethical dimension of a care of care words when a way of speaking imposes itself on them. It also questions the epistemological and ethical pluralism involving medicine between science, clinical and politics.The world has changed this year under the shadow of the COVID-19 pandemic. selleck chemicals Lockdowns around the world have reduced energy demand, resulting in emissions declines, but what could the post-COVID-19 world look like - a return to normal, or will this start a transition?Solutions to global sustainability challenges are increasingly technology-intensive. Yet, technologies are neither developed nor applied to governance problems in a socio-political vacuum. Despite aspirations to provide novel solutions to current sustainability governance challenges, many technology-centred projects, pilots and plans remain implicated in longer-standing global governance trends shaping the possibilities for success in often under-recognized ways. This article identifies three overlapping contexts within which technology-led efforts to address sustainability challenges are evolving, highlighting the growing roles of (1) private actors; (2) experimentalism; and (3) informality. The confluence of these interconnected trends illuminates an important yet often under-recognized paradox that the use of technology in multi-stakeholder initiatives tends to reduce rather than expand the set of actors, enhancing instead of reducing challenges to participation and transparency, and reinforcing rather than transforming existing forms of power relations. Without recognizing and attempting to address these limits, technology-led multi-stakeholder initiatives will remain less effective in addressing the complexity and uncertainty surrounding global sustainability governance. We provide pathways for interrogating the ways that novel technologies are being harnessed to address long-standing global sustainability issues in manners that foreground key ethical, social and political considerations and the contexts in which they are evolving.Rhizoma Polygonati (huangjing in Chinese, ) is a medicine food homology herb used as a component of traditional Chinese medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain elusive. Here using TCMSP and Swiss Target Prediction databases to sort out the potential targets of the main chemical components and GenCLiP3, NCBI, and GeneCard databases to search for COVID-19 related targets, the chemical compound-target-pathway network was analyzed. Each component was molecularly docked with host cell target angiotensin converting enzyme II, SARS-CoV-2 targets Spike protein, RNA-dependent RNA polymerase, or 3CL hydrolase. Our results showed a higher affinity of the compound diosgenin and (+)-Syringaresinol-O-beta-D-glucoside binding to the three SARS-CoV-2 proteins compared to the other compounds tested. Thus, our data suggest that potential compounds in Rhizoma Polygonati may act on different targets with viral and cancer related signaling and have a great potential in treatment of COVID-19.Deltacoronavirus is the last identified Coronaviridae subfamily genus. Differing from other coronavirus (CoV) genera, which mainly infect birds or mammals, deltacoronaviruses (δ-CoVs) reportedly infect both animal types. Recent studies show that a novel δ-CoV, porcine deltacoronavirus (PDCoV), can also infect calves and chickens with the potential to infect humans, raising the possibility of cross-species transmission of δ-CoVs. Here, we explored the deep phylogenetic history and cross-species transmission of δ-CoVs. Virus-host co-phylogenetic analyses showed that δ-CoVs have undergone frequent host switches in birds, and sparrows may serve as the unappreciated hubs for avian to mammal transmission. Our molecular clock analyses show that PDCoV possibly originated in Southeast Asia in the 1990s, and that the PDCoV cluster shares a common ancestor with Sparrow-CoV of around 1810. Our findings contribute valuable insights into the diversification, evolution, and interspecies transmission of δ-CoVs and the origin of PDCoV, providing a model for exploring the relationships of δ-CoVs in birds and mammals.The emergence of SARS-CoV-2 has resulted in nearly 1,280,000 infections and 73,000 deaths globally so far. This novel virus acquired the ability to infect human cells using the SARS-CoV cell receptor hACE2. Because of this, it is essential to improve our understanding of the evolutionary dynamics surrounding the SARS-CoV-2 hACE2 interaction. One way theory predicts selection pressures should shape viral evolution is to enhance binding with host cells. We first assessed evolutionary dynamics in select betacoronavirus spike protein genes to predict whether these genomic regions are under directional or purifying selection between divergent viral lineages, at various scales of relatedness. With this analysis, we determine a region inside the receptor-binding domain with putative sites under positive selection interspersed among highly conserved sites, which are implicated in structural stability of the viral spike protein and its union with human receptor ACE2. Next, to gain further insights into factors associated with recognition of the human host receptor, we performed modeling studies of five different betacoronaviruses and their potential binding to hACE2. Modeling results indicate that interfering with the salt bridges at hot spot 353 could be an effective strategy for inhibiting binding, and hence for the prevention of SARS-CoV-2 infections. We also propose that a glycine residue at the receptor-binding domain of the spike glycoprotein can have a critical role in permitting bat SARS-related coronaviruses to infect human cells.The person-to-person transmission of SARS-CoV-2 may occur directly or indirectly through saliva, and a preoperational use of antimicrobial mouthwash is considered to reduce the number of oral microbes. 1 Chlorhexidine mouthwash has been a common antiseptic agent used in dentistry, both preoperative and postoperative use reducing post-surgical infectious complications.