Adairknapp1325

RESULTS HAMI hydrogels can filter harmful short-wavelength blue light and showed other necessary properties like visible light transparency, glass transition temperatures, mechanical strength, and biocompatibility for making intraocular lenses. In addition, MAA increased the hydrophilicity of the hydrogels, resulting in a lower water contact angle and faster drug release from the hydrogels. CONCLUSION In summary, HAMI hydrogels show great potential as IOL biomaterials that can maintain the sustained release of indomethacin and filter harmful blue light after cataract surgery. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND The abilities to form biofilm and produce several virulence factors have caused numerous human pathogens to become tremendously resistant towards traditional antibiotic treatments, thus, new alternative strategies are urgently demanded. One of the strategies that has recently been developed involves the nanoparticles (NPs) based on metal NPs. Up to the present, promising results in terms of antimicrobial and antibiofilm activities have been observed in a wide range of metal NPs. OBJECTIVE The present study has selected several metal oxides such as ZnO, SnO2 and CeO2 NPs to investigate their antibiofilm and antibacterial properties against two Gram positive human pathogens which are Listeria monocytogenes and Staphylococcus aureus. METHOD The anti-biofilm activity of ZnO, SnO2 and CeO2 NPs against Listeria monocytogenes and Staphylococcus aureus were assayed by crystal violet staining and confirmed by microscopic visualization using Sem and fluorescence microscope. The production of amyloid protein s in biomedical fields and food industry. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia cultivar), to peripheral lymphomonocytes from patients affected by allergic contact dermatitis (ACD) to nickel (Ni) could reduce release of pro-inflammatory cytokines and nitric oxide (NO), while increasing levels of interleukin (IL)-10, an anti-inflammatory cytokine. OBJECTIVE To assess whether an intervention with oral administration of polyphenols leads to a reduction of peripheral biomarkers in ACD patients. METHOD At T0, 25 patients affected by ACD to Ni were orally administered with 300 mg polyphenols prodie extracted from seeds of red grape (Nero di Troia cultivar) (NATUR-OX®) for 3 months (T1). Other 25 patients affected by ACD to Ni received placebo only for the same period of time. Serum biomarkers were analyzed at T0 and T1. In both groups seven drop outs were recorded. RESULT At T1 in comparison to T0, in treated patients, values of IFN-γ, IL-4, IL-17, PTX3 and NO decreased, while IL-10 levels increased when compared with T0 values. Conversely, in placebo-treated patients no modifications of biomarkers were evaluated at T1. CONCLUSION Present laboratory data rely on the anti-oxidant, anti-inflammatory and anti-allergic properties of polyphenols. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.AIMS The present study aims at analyzing CU score with respect to time, as a time-series. We have attempted to model the investigated time-series in order to unravel possible causative relationships. BACKGROUND Chronic spontaneous urticaria (CSU, or CU) is a disease that significantly affects the quality of life of patients. It is a chronic disease and requires a specialized approach to diagnosis and treatment. In recent years, the disease has been of great interest due to the existence of new targeted therapeutic approaches. find more OBJECTIVE Time series were produced by assessing the patient's CU score. Urticaria score was assessed on the basis of Urticaria Activity Score 7 (UAS7), according to the proposed guidelines. METHOD 108 patients (25Males/83Females) admitted to our department were diagnosed with CU. CU was estimated on score basis, which was used in order to define disease severity. The mean CU score, the mean CU score rate with respect to the first month at diagnosis as well as the monthly CU score rate were calculated. RESULT Gender is a factor that influences CU score with respect to time. In addition, there was a significant finding that time-series were different with respect to the administration of monotherapy or complementary therapy. CONCLUSION We have found that females are more prone to CU, while omalizumab monotherapy has more beneficial results as compared to the application of concurrent and maintenance therapies. Further on, patients with co-morbidities were more likely to interrupt therapy. Finally, and most significantly, it was shown that monthly CU score rate manifested an oscillatory pattern, which was modelled with sum of sines functions, hinting towards a relative immunological pattern. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.INTRODUCTION Tuberculosis (TB) remains as one of the most important infectious causes of death through the world. A wide range of technologies have been used for the diagnosis of TB. However, current diagnostic tests are inadequate. The aim of this study was to evaluate expression of four genes, namely ASUN, NEMF, PTPRC and DHX29 as candidate biomarkers for the discrimination of Latent tuberculosis infection (LTBI) and active TB among individuals with active TB, LTBI, and healthy Bacilli Calmette-Guerin (BCG) vaccinated cases. MATERIAL AND METHODS The expression of the mentioned four genes as well as ACTB as a housekeeping gene was evaluated by real-time PCR. Receiver operating characteristic (ROC) curve analysis was conducted to assess the specificity and sensitivity of each validated biomarker. RESULTS The results of real-time PCR presented that these four differentially expressed genes could be perceived as potential biomarkers for the detection of active and latent TB infections. ROC analysis showed that the expression level of ASUN, PTPRC and DHX29 may discriminate active TB patients from healthy individuals, whereas ASUN and NEMF could differentiate LTBI from healthy BCG vaccinated cases. In addition, DHX29 and PTPRC could be used to discriminate LTBI from active TB patients. CONCLUSION Expression of these four host genes can accurately differentiate between active TB/LTBI cases and healthy individuals as well as between LTBI and active TB patients. However, our findings deserve further validation in larger studies. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.