Abernathyhermann4181

Crowd monitoring systems (CMSs) provide a state-of-the-art solution to manage crowds objectively. Most crowd monitoring systems feature one type of sensor, which severely limits the insights one can simultaneously gather regarding the crowd's traffic state. Incorporating multiple functionally complementary sensor types is expensive. CMSs are needed that exploit data fusion opportunities to limit the number of (more expensive) sensors. This research estimates a data fusion algorithm to enhance the functionality of a CMS featuring Wi-Fi sensors by means of a small number of automated counting systems. Here, the goal is to estimate the pedestrian flow rate accurately based on real-time Wi-Fi traces at one sensor location, and historic flow rate and Wi-Fi trace information gathered at other sensor locations. learn more Several data fusion models are estimated, amongst others, linear regression, shallow and recurrent neural networks, and Auto Regressive Moving Average (ARMAX) models. The data from the CMS of a large four-day music event was used to calibrate and validate the models. This study establishes that the RNN model best predicts the flow rate for this particular purpose. In addition, this research shows that model structures that incorporate information regarding the average current state of the area and the temporal variation in the Wi-Fi/count ratio perform best.The rumen is an important digestive organ of ruminants. From the fetal to adult stage, the morphology, structure and function of the rumen change significantly. However, the knowledge of the intrinsic genetic regulation of these changes is still limited. We previously reported a genome-wide expression profile of miRNAs in pre-natal goat rumens. In this study, we combined and analyzed the transcriptomes of rumen miRNAs during pre-natal (E60 and E135) and post-natal (D30 and D150) stages. A total of 66 differentially expressed miRNAs (DEMs) were identified in the rumen tissues from D30 and D150 goats. Of these, 17 DEMs were consistently highly expressed in the rumens at the pre-weaning stages (E60, E135 and D30), while down-regulated at D150. Noteworthy, annotation analysis revealed that the target genes regulated by the DEMs were mainly enriched in MAPK signaling pathway, Jak-STAT signaling pathway and Ras signaling pathway. Interestingly, the expression of miR-148a-3p was significantly high in the embryonic stage and down-regulated at D150. The potential binding sites of miR-148a-3p in the 3'-UTR of QKI were predicted by the TargetScan and verified by the dual luciferase report assay. The co-localization of miR-148a-3p and QKI through in situ hybridization was observed in the rumen tissues but not in the intestinal tracts. Moreover, the expression of miR-148a-3p in the epithelium was significantly higher than that in the other layers of the rumen, suggesting that miR-148a-3p is involved in the development of the rumen epithelial cells by targeting QKI. Subsequently, miR-148a-3p inhibitor was found to induce the proliferation of GES-1 cells. Taken together, our study identified DEMs involved in the development of the rumen and provides insights into the regulation mechanism of rumen development in goats.Carbon fiber reinforced polycarbonate (CF/PC) composites have attracted attention for their excellent performances. However, their performances are greatly affected by environmental factors. In this work, the composites were exposed to hydrothermal aging to investigate the effects of a hot and humid environment. The mechanical properties of CF/PC composites with different aging times (0, 7, 14, 21, 28, 35, and 42 days) were analyzed. It was demonstrated that the storage modulus of CF/PC composites with hot water aged for seven days has the highest value in this sampling period and frequency. Through the solid particle erosion experiment, it was found that the hydrothermal aging causes the deviation of the maximum erosion angle of composites, indicating the composites underwent ductile-brittle transformation. Furthermore, the crack and cavity resulting from the absorption of water was observed via the scanning electron microscope (SEM). This suggested that the hydrothermal aging leads to the plasticization and degradation of CF/PC composites, resulting in a reduction of corrosion resistance.Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) have recently been revealed to be related to chronic inflammation, oxidative stress, and the accumulation of reactive oxygen species. It has been proposed that MPNs represent a human inflammation model for tumor advancement, in which long-lasting inflammation serves as the driving element from early tumor stage (over polycythemia vera) to the later myelofibrotic cancer stage. It has been theorized that the starting event for acquired stem cell alteration may occur after a chronic inflammation stimulus with consequent myelopoietic drive, producing a genetic stem cell insult. When this occurs, the clone itself constantly produces inflammatory components in the bone marrow; these elements further cause clonal expansion. In BCR-ABL1-negative MPNs, the driver mutations include JAK 2, MPL, and CALR. Transcriptomic studies of hematopoietic stem cells from subjects with driver mutations have demonstrated the upregulation of inflammation-related genes capable of provoking the development of an inflammatory state. The possibility of acting on the inflammatory state as a therapeutic approach in MPNs appears promising, in which an intervention operating on the pathways that control the synthesis of cytokines and oxidative stress could be effective in reducing the possibility of leukemic progression and onset of complications.Control of the crop pest African cotton leafworm, Spodoptera littoralis (Boisduval), by chemical insecticides has led to serious resistance problems. Ajuga plants contain phytoecdysteroids (arthropod steroid hormone analogs regulating metamorphosis) and clerodanes (diterpenoids exhibiting antifeedant activity). We analyzed these compounds in leaf extracts of the Israeli Ajuga iva L. by liquid chromatography time-of-flight mass spectrometry (LC-TOF-MS) and thin-layer chromatography (TLC), and their efficiency at reducing S.littoralis fitness. First and third instars of S. littoralis were fed castor bean leaves (Ricinus communis) smeared with an aqueous suspension of dried methanolic crude extract of A. iva phytoecdysteroids and clerodanes. Mortality, larval weight gain, relative growth rate and survival were compared to feeding on control leaves. We used '4',6-diamidino-2-phenylindole (DAPI, a fluorescent stain) and phalloidin staining to localize A. iva crude leaf extract activity in the insect gut. Ajuga iva crude leaf extract (50, 100 and 250 µg/µL) significantly increased mortality of first-instar S.