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Contaminated soil and vegetables have continued to instigate threat to human health globally and specially in developing countries. This study was aimed to determine concentrations of certain heavy metals in soil and vegetables (cabbage and tomato) from Koka area of central Ethiopia using Inductively Coupled Plasma Optical Emission Spectrophotometer (ICP-OES). The amounts of As, Pb, Cd, Zn, Cu, Hg and Co detected in soil samples were found to surpass the reference values for agricultural soil. Similarly, the concentrations of As, Pb, Cd, Cr and Hg obtained in both tomato and cabbage samples have exceeded the recommended values with the mean levels generally ranging from 0.93-6.76, 1.80-7.26, 0.33-1.03, 0.86-5.16 and 3.23-4.36 mg/kg dry weight, respectively. The result obtained have signified that leafy vegetable has hoarded heavy metals more than non-leafy vegetable. The total hazard quote for As and Hg from tomato ingestion and for As, Hg and Co from cabbage ingestion were greater than unity, signifying potential health hazard to the public. The health index (HI) owing to tomato and cabbage ingesting were 5.44 and 14.21, respectively, signifying likely adversative health implication to the population from the ingestion of the vegetables. The Total Cancer Risk (TCR) analysis have uncovered the possible cancer hazard persuaded by Cd, Hg, As and Ni from the ingestion of both vegetables. From the outcomes this study, it can be concluded that the soil and vegetables from Koka areas are possibly contaminated with toxic metals and hence demand strict monitoring to safeguard the public around the study area and beyond.

Health-seeking behaviour, stigma, and discrimination towards people affected by tuberculosis (TB) are influenced by awareness of the disease. read more Gender differentials in the diagnosis and treatment of TB have been reported in other settings of the world. However, little is known about the gender differences in the knowledge of TB transmission and curative possibility in Ghana.

The analysed data were a weighted sample of 9,396 women aged 15-49 years and 4,388 men aged 15-59 years, obtained from the 2014 Ghana Demographic and Health Survey. The dependent variable, correct knowledge regarding TB transmission and cure was derived from questions on the transmission of the disease and the possibility of a cure. A design-based multivariate logistic regression model in Stata 13.0/SE was used to identify the correlates of reporting correct knowledge.

Overall, the mean knowledge score was 6.1±0.9 (maximum = 7). Of the 13,784 respondents, 45.7% (95% CI 44.0-47.3) reported correct knowledge regarding TB transmission ancted by the disease.

There was low knowledge regarding TB transmission and cure. Misconceptions regarding the transmission of TB prevailed among the participants. Gender differential in knowledge was observed. Comparatively, females were less likely to be aware of TB and report correct knowledge regarding TB transmission but were more likely to conceal information when a household member was affected by the disease.An appropriate exposure to the light-dark cycle, with high irradiances during the day and darkness during the night is essential to keep our physiology on time. However, considering the increasing exposure to artificial light at night and its potential harmful effects on health (i.e. chronodisruption and associated health conditions), it is essential to understand the non-visual effects of light in humans. Melatonin suppression is considered the gold standard for nocturnal light effects, and the activation of intrinsically photosensitive retinal ganglion cells (ipRGCs) through the assessment of pupillary light reflex (PLR) has been recently gaining attention. Also, some theoretical models for melatonin suppression and retinal photoreceptors activation have been proposed. Our aim in this study was to determine the influence of correlated color temperature (CCT) on melatonin suppression and PLR, considering two commercial light sources, as well as to explore the possible correlation between both processes. Also suggested that CCT should not be considered separately from irradiance when designing nocturnal/diurnal illumination systems. Further experimental studies on wider ranges of CCTs and light intensities are needed to confirm these conclusions.

Antiretroviral therapy (ART) coverage in South Sudan is around 10%. Access to HIV care in settings with low ART coverage or conflict affected is still low; innovative strategies are needed to increase access and ensure continuation of ART during instability. A pilot HIV test and start project was implemented in a conflict-affected area of South Sudan. In a retrospective analysis, we determined the feasibility and outcomes of this intervention.

Programme data from July 2015 to June 2018 was analysed. The project involved five mobile teams offering HIV counselling and testing (HCT) and same day ART initiation at community level. Baseline and follow-up information on clinical, immunological and viral load (VL) was routinely recorded, as well as treatment outcomes. A semi-qualitative study was conducted to assess acceptability of the program among beneficiaries and community members.

By June 2018, 14824 people received counselling and testing for HIV and 498 (3.4%) tested positive. Out of those 395 (79.3%) contexts. This model could be extrapolated to other similar contexts with low access to ART and where security situation is a concern.

Our study shows that HCT and early ART initiation in conflict affected populations can be provided with good program outcomes. RIC and virological suppression are comparable with facility-based HIV programs and to those in stable contexts. This model could be extrapolated to other similar contexts with low access to ART and where security situation is a concern.

A highly sensitive triage test that captures most symptomatic patients at increased likelihood of having pulmonary tuberculosis (PTB) would 'rule-out' lower-risk patients from expensive confirmatory testing. Although studies have assessed the diagnostic accuracy of a C-reactive protein (CRP) triage test for PTB in HIV+ patients, limited data are available from HIV- cohorts.

In this retrospective case-control study, 765 serum samples were selected from FIND's biobank. Each sample had been collected from an adult presenting with respiratory symptomatology to district hospitals in South Africa and referral hospitals in Cambodia, Peru, Georgia and Vietnam between 2007-2017. Serum CRP measurements were obtained using a laboratory-based assay. CRP cutoff-points of ≥8mg/L and ≥10mg/L were predefined as a positive triage test result. The PTB reference standard was two contemporaneously collected sputum liquid culture results.

CRP demonstrated an overall sensitivity for PTB of 79.8% (95%CI 75.5-83.5) and 77.7% (95%CI 73.

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