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Purpose Focal therapies (FTs) are investigated within prospective studies on selected patients treated for localized prostate cancer (PCa). Benefits are preservation of genitourinary function and reduced complications, but follow-up is elaborate and is associated with uncertainty as cancer-free survival appears to be lower compared to standard radical treatments. The aim of this study was to analyse patient-reported acceptance of FT and evaluate factors associated with treatment decision regret. FRAX597 manufacturer Methods 52 patients who received focal high-intensity focused ultrasound for low- to intermediate-risk PCa between 2014 and 2019 within two prospective trials were eligible for a survey regarding PCa-related treatment regret and quality-of-life (Clark's scale) and the following potential predictors sociodemographic variables, Charlson Comorbidity Index, subjective aging (AARC-10 SF), and general health-related quality-of-life (SF-12). Cancer persistence/recurrence (multiparametric MRI and fusion biopsy after 12 months) and functional outcomes (EPIC-26 UI/UIO/S) data were also included in this study. Results The overall survey response rate was 92.3% (48/52 patients). Median follow-up was 38 months (interquartile range = 25-50 months). In total, ten patients (20.8%) reported treatment decision regret. In univariable analyses, a clinically meaningful increase in urinary incontinence showed a significant association (OR 4.43; 95% CI 0.99-20.53; p = 0.049) with regret. Cancer recurrence (OR 12.31; 95% CI 1.78-159.26; p = 0.023) and general health worry as a domain of Clark's scale (OR 1.07; 95% CI 1.03-1.14; p less then 0.01) were predictors of regret in a multivariable logistic regression model (AUC = 0.892). Conclusion Acceptance of FT is comparable to standard treatments. Extensive follow-up including regular PSA testing does not cause additional regret but careful patient selection and information before FT is crucial.Background Nostril sill asymmetry is one of the most challenging problems in rhinoplasty. Some studies have been performed regarding nostril shape; however, no studies have been conducted on nostril shape in the Persian population. Additionally, the shape of the nostril in frontal view has rarely been evaluated. This study has two aims. The first is to evaluate nostril shape in Persian patients who were candidates for primary rhinoplasty in basal and frontal views. The second is to assess augmentation silloplasty in patients with different sill heights to resolve nostril asymmetry. Methods This research was performed in two phases. The first phase was a cross-sectional study carried out on the deidentified photographs of 122 patients nominated for rhinoplasty surgery at the facial plastic clinic of a tertiary university hospital. The second phase of the research was an interventional study without a control group consisting of 22 patients. The subjects were categorized as Phase 1. Next, an attempt was made tofor correcting nasal base asymmetry. Augmentation silloplasty can help surgeons correct nostril asymmetry due to sill height discrepancy. Level of evidence iv This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.Purpose This prospective study was performed to investigate long-term (8-year) survival in patients with solitary large hepatocellular carcinoma (HCC) ranging from 5 to 7 cm who underwent transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) and identify factors that significantly affected outcomes. Methods Forty-eight patients with large HCC (36 men, 12 women; mean age, 57.0 ± 11.2 [range, 37-82] years) without fever or signs of infection were enrolled. All patients were treated with TACE + RFA. Overall survival (OS) and disease-free survival (DFS) were calculated using the Kaplan-Meier method. Prognostic factors were assessed using the Cox hazards regression method. Results The median OS duration was 47.0 months, and the 1-, 3-, 5-, and 8-year OS rates were 73%, 57%, 53%, and 27%, respectively. The median DFS duration was 9.05 (3.99-12.01) months, and the 1-, 3-, and 5-year DFS rates were 35%, 9%, and 0%, respectively. Cox hazards regression analysis revealed that the Child-Pugh class, platelet count, lymphocyte-to-monocyte ratio (LMR), and DFS were independent predictive factors of OS (p = 0.000, 0.003, 0.020, and 0.000, respectively). The LMR and platelet-to-lymphocyte ratio (PLR) were independent predictive factors of recurrence (p = 0.046 and 0.016, respectively). Conclusion TACE + RFA may be a safe and effective treatment for selected solitary large HCC ranging from 5 to 7 cm. Measurement of the LMR (> 4) and PLR (≤ 100) in peripheral blood before the intervention might help to identify which patients with solitary large HCC are suitable for TACE + RFA. Registration number ChiCTR-TRC-12002768 (https//www.chictr.org.cn).Purpose Repetitive or sustained simple muscle contractions have been shown to alter corticomotor excitability. The present study investigated the effects of a sustained handgrip contraction with the right hand on motor-evoked potentials (MEPs) in task-unrelated knee extensor muscles and determined whether the effects are influenced by intensity of the handgrip contraction. Methods Subjects performed a 120-s sustained handgrip contraction at 10% or 50% maximal voluntary contraction (MVC) using the right hand. MEPs in vastus lateral (VL) muscles elicited by transcranial magnetic stimulation were measured before, during, and after the handgrip contraction. Results Both the handgrip contractions at 10 and 50% MVC induced significant greater MEPs in the left VL muscle (121.5 ± 25.7%) than in the right VL muscle (97.9 ± 17.4%) from 10 min after the handgrip contraction (P less then 0.05). MEPs in both the right and left VL muscles were significantly increased by the handgrip contractions at 10% MVC (124.8 ± 45.2%, P less then 0.05), but were not increased by the handgrip contractions at 50% MVC. Conclusion The results of the present study indicate that a unilateral sustained handgrip contraction can differentially alter corticomotor excitability in knee extensor muscles ipsilateral and contralateral to the exercised hand after the handgrip and that the intensity of the handgrip contraction influences corticomotor excitability in both knee extensor muscles after the handgrip.