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08 (95% CI 0.89-1.30) for females and 0.81 (95% CI 0.66-0.97) for males. The age-specific SMRs were 3.36 (95% CI 1.61-6.18), 0.97 (95% CI 0.68-1.34), 0.88 (95% CI 0.73-1.06) and 0.86 (95% CI 0.66-1.11) for 20-39, 40-59, 60-79 and above 80 years of age, respectively. Major causes of death included malignant neoplasms (n=61; SMR=0.97, 95% CI 0.72-1.28), acute myocardial infarction (n=32; SMR=1.11, 95% CI 0.74-1.58), and pneumonia (n=14; SMR=2.46, 95% CI 1.27-4.31). Factors found to be associated with increased mortality include elevated acute phase reactants, presence of comorbidities such as heart disease and cancer, and lower education level. Conclusion Young patients with PsA are at increased mortality risk. Better control of comorbidities may reduce this risk.Background Plantar pressure reduction with the use of cushioning materials play an important role in the clinical management of the diabetic foot. Previous studies in people without diabetes have shown that appropriate selection of the stiffness of such materials can significantly enhance their capacity to reduce pressure. However the significance of optimised cushioning has not been yet assessed for people with diabetic foot syndrome. Research question What is the potential benefit of using footwear with optimised cushioning, with regards to plantar pressure reduction, in people with diabetes and peripheral neuropathy? Methods Plantar pressure distribution was measured during walking for fifteen people with diabetic foot syndrome in a cohort observational study. The participants were asked to walk in the same type of footwear that was fitted with 3D-printed footbeds. These footbeds were used to change the stiffness of the entire sole-complex of the shoe; from very soft to very stiff. The stiffness that achieshioning stiffness on a patient-specific basis.Background The relationship between body mass index (BMI) and risk of venous thromboembolism (VTE) and pulmonary embolism (PE) is a controversial issue. This dose-response meta-analysis was performed to investigate the association between BMI and risk of VTE and PE incidence based on cohort studies. Method A comprehensive systematic search was conducted up to August 2019 in MEDLINE/PubMed, SCOPUS, and Cochrane. DerSimonian and Laird random-effects models were run to estimate combined hazard ratios (HRs) with 95% confidence intervals (CIs). Dose-response analysis was also carried out based on BMI values. Results Eleven articles with 16 arms and 3,910,747 participants were eligible for inclusion in this systematic review and meta-analysis. Pooled results showed a positive association between BMI and risk of VTE in the obese participants compared to participants classified in the normal BMI category (HR 1.62, 95% CI 1.29-2.04, I2 = 95%). Furthermore, results showed a significant association between lower BMI (underweight versus normal BMI category) and reduced risk of PE (HR 0.80, 95% CI 0.70-0.92, I2 = 9%) and higher risk of PE in obese versus normal BMI participants (HR 2.24, 95% CI 1.93-2.60, I2 = 0%). There was a significant linear relationship between BMI and risk of VTE (p less then 0.001) and PE (p less then 0.001). Conclusions This systematic review and dose-response meta-analysis with 3,910,747 participants highlights obesity as a significant risk factor related to the incidence of VTE and PE.Background Screening guidelines recommend listening closely to parent concerns to aid in the identification of children with disabilities, since parent concerns may be predictive of an eventual child diagnosis. Methods We performed a secondary analysis to examine the extent to which specific parent concerns differentiated six diagnostic categories (i.e., ASD, ASD + ADHD, Disruptive Impulse-Control and Conduct Disorder, developmental delays, and speech and language disorders) among 503 children 36-72 months of age. Data was drawn for a large diagnostic center in the Midwest. Results We performed multinomial logistic regression with parent concerns differentiating six diagnostic categories. Results indicated that parent concerns preceding a diagnostic evaluation significantly differ among children with various diagnoses. Conclusion Parent concerns often aligned with core diagnostic criteria; regardless of a parent's knowledge of diagnostic criteria, their observations of child behavior are exceptionally insightful.Objective According to prevalence studies, at least 5-6 % of women in Europe experience rape in their lives. The initial treatment after a sexual assault can influence the individual healing process positively. In Germany, there are hardly any studies that investigate larger collection of cases of sexual assault treated in hospitals. However, knowledge about characteristics of cases of sexual assault is a prerequisite for the optimal processing of primary care. Study design For this study, the retrospective collection of data on cases of suspected sexual assault of patients presented for treatment at the Charité was carried out. Standardized findings sheets as part of a rape kit used in all cases were evaluated. Overall, 850 cases from the period between 01.01.2011 and 30.06.2016 were analyzed. The statistical evaluation was descriptive. Results The median age of patient was 26 years (range 16-92). Penetration (vaginal/anal/oral) occurred in 75 % of cases. The suspect was unknown to 48,4 % of those affected, hould consider that the majority of those affected present themselves at the weekend.Objective Actigraphy is a non-intrusive method of recording rest/activity cycles as well as a surrogate for sleep/wake activity. Standard actigraphy analysis is limited in ascribing discrete movement events to wake status during sleep. We applied a novel algorithm to overnight actigraphy data recorded simultaneously with video polysomnography-electroencephalography (video PSG-EEG) to determine its ability to define movement and sleep/wake patterns in children with autism spectrum disorder (ASD) and age-comparable typically developing (TD) controls. Methods A previously published novel algorithm uses mathematical endpoints to analyze actigraphy data without assumptions about sleep/wake status, and smooths data using moving windows of increasing length. Nighttime activity level "S" events (S1-S5) determined by this algorithm (n = 273) were identified in 15 children ages 3-10 years (nine with ASD and six TD) who wore an AW2 Spectrum Actiwatch (Philips Respironics) while undergoing simultaneous video PSG-EEG. this website Data were analyzed to identify the time each activity level "S" event occurred, video movement events (movements captured by video and scored based on level of severity), and sleep/wake status defined by PSG-EEG.