Engberglawrence4315

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide and encompasses chronic bronchitis and emphysema. It has been shown that vascular wall remodeling and pulmonary hypertension (PH) can occur not only in patients with COPD but also in smokers with normal lung function, suggesting a causal role for vascular alterations in the development of emphysema. Mechanistically, abnormalities in the vasculature, such as inflammation, endothelial dysfunction, imbalances in cellular apoptosis/proliferation, and increased oxidative/nitrosative stress promote development of PH, cor pulmonale, and most probably pulmonary emphysema. Hypoxemia in the pulmonary chamber modulates the activation of key transcription factors and signaling cascades, which propagates inflammation and infiltration of neutrophils, resulting in vascular remodeling. Endothelial progenitor cells have angiogenesis capabilities, resulting in transdifferentiation of the smooth muscle cells via aberrant activation of several cytokines, growth factors, and chemokines. The vascular endothelium influences the balance between vaso-constriction and -dilation in the heart. Targeting key players affecting the vasculature might help in the development of new treatment strategies for both PH and COPD. The present review aims to summarize current knowledge about vascular alterations and production of reactive oxygen species in COPD. The present review emphasizes on the importance of the vasculature for the usually parenchyma-focused view of the pathobiology of COPD.Coronary artery disease (CAD) is the main reason of cardiovascular mortalities worldwide. This condition is resulted from atherosclerotic occlusion of coronary arteries. MicroRNAs (miRNAs) are implicated in the regulation of proliferation and apoptosis of endothelial cells, induction of immune responses and different stages of plaque formation. Up-regulation of miR-92a-3p, miR-206, miR-216a, miR-574-5p, miR-23a, miR-499, miR-451, miR-21, miR-146a, and a number of other miRNAs has been reported in CAD patients. In contrast, miR-20, miR-107, miR-330, miR-383-3p, miR-939, miR-4306, miR-181a-5p, miR-218, miR-376a-3p, and miR-3614 are among down-regulated miRNAs in CAD. Differential expression of miRNAs in CAD patients has been exploited to design diagnostic or prognostic panels for evaluation of CAD patients. We appraise the recent knowledge about the role of miRNAs in the development of diverse clinical subtypes of CAD.Finding the shortest tour visiting all given points at least ones belongs to the most famous optimization problems until today [travelling salesman problem (TSP)]. Optimal solutions exist for many problems up to several ten thousand points. The major difficulty in solving larger problems is the required computational complexity. This shifts the research from finding the optimum with no time limitation to approaches that find good but sub-optimal solutions in pre-defined limited time. click here This paper proposes a new approach for two-dimensional symmetric problems with more than a million coordinates that is able to create good initial tours within few minutes. It is based on a hierarchical clustering strategy and supports parallel processing. In addition, a method is proposed that can correct unfavorable paths with moderate computational complexity. The new approach is superior to state-of-the-art methods when applied to TSP instances with non-uniformly distributed coordinates.Walking animals demonstrate impressive self-organized locomotion and adaptation to body property changes by skillfully manipulating their complicated and redundant musculoskeletal systems. Adaptive interlimb coordination plays a crucial role in this achievement. It has been identified that interlimb coordination is generated through dynamical interactions between the neural system, musculoskeletal system, and environment. Based on this principle, two classical interlimb coordination mechanisms (continuous phase modulation and phase resetting) have been proposed independently. These mechanisms use decoupled central pattern generators (CPGs) with sensory feedback, such as ground reaction forces (GRFs), to generate robot locomotion autonomously without predefining it (i.e., self-organized locomotion). A comparative study was conducted on the two mechanisms under decoupled CPG-based control implemented on a quadruped robot in simulation. Their characteristics were compared by observing their CPG phase convergence processes at different control parameter values. Additionally, the mechanisms were investigated when the robot faced various unexpected situations, such as noisy feedback, leg motor damage, and carrying a load. The comparative study reveals that the phase modulation and resetting mechanisms demonstrate satisfactory performance when they are subjected to symmetric and asymmetric GRF distributions, respectively. This work also suggests a strategy for the appropriate selection of adaptive interlimb coordination mechanisms under different conditions and for the optimal setting of their control parameter values to enhance their control performance.Virtual humans (VHs)-automated, three-dimensional agents-can serve as realistic embodiments for social interactions with human users. Extant literature suggests that a user's cognitive and affective responses toward a VH depend on the extent to which the interaction elicits a sense of copresence, or the subjective "sense of being together." Furthermore, prior research has linked copresence to important social outcomes (e.g., likeability and trust), emphasizing the need to understand which factors contribute to this psychological state. Although there is some understanding of the determinants of copresence in virtual reality (VR) (cf. Oh et al., 2018), it is less known what determines copresence in mixed reality (MR), a modality wherein VHs have unique access to social cues in a "real-world" setting. In the current study, we examined the extent to which a VH's responsiveness to events occurring in the user's physical environment increased a sense of copresence and heightened affective connections to the VH. Participants (N = 65) engaged in two collaborative tasks with a (nonspeaking) VH using an MR headset.