Brixmccurdy2997

Intriguingly, the microRNA (miRNA) analysis revealed an increased expression of miR-193-5p, miR-221, miR-212, and miR-183-5p in CKD, while an increased mRNA expression of anti-inflammatory cytokines and reduced level of pS6K with attenuated miRNA was found in rapamycin-treated rats compared to the CKD animals. Conclusion Activation of mTOR is the major responsive element with activation of miRNAs as an elementary role in the progression of kidney disease. Hence, targeting mTOR would be a possible strategy of treatment for CKD.Background Due to declining birthrates and an increasing aging population, shortage of the caregiving labor force has become a global issue. Among various efforts toward the solution, introducing robotic products for assistance could provide an effective way to help older adults in their daily lives. As previous studies have indicated that older adults' acceptance of robots is lower than that of younger adults, enhancing older adults' acceptance of robots is imperative. Because older adults' first impressions based on a robot's appearance might affect their acceptance of the robot, we investigated the uncanny valley effect (UVE) here. The UVE refers to the phenomenon that people rate robots more positively as robots become more humanlike, but only up to a certain point; as robots approach a near-perfect similarity to human appearance, likeability drops and forms the uncanny valley. Nevertheless, evidence for the UVE came mainly from younger adults. Objective The present study aimed to examine whether the UVE varies across different age groups and whether a robot's appearance would affect participants' acceptance of the robot's service or companionship. Methods An online questionnaire study was conducted with 255 participants, including younger (n = 77, age 18-39 years), middle-aged (n = 87, age 40-59 years), and older (n = 91, age 60-87 years) adults. Participants were asked to view each picture in a set selected from a total of 83 robot pictures and evaluate their impressions of each robot and the intention of use regarding robot function as a service provider or a companion. Results The UVE was found in younger and middle-aged adults; however, older adults did not show the UVE. Older adults preferred humanlike over non-humanlike robots, regardless of robot function. Conclusion The design of assistive robots should take the UVE into consideration by customizing robot appearance based on the age group of the intended user.Interaction of two skyrmions stabilized by the ferromagnetic exchange, Dzyaloshinskii-Moriya interaction (DMI), and external magnetic field has been studied numerically on a 2D lattice of size large compared to the separation, $d$, between the skyrmions. We show that two skyrmions of the same chirality (determined by the symmetry of the crystal) repel. In accordance with earlier analytical results, their long-range pair interaction falls out with the separation as $\exp(-d/\delta_H)$, where $\delta_H$ is the magnetic screening length, independent of the DMI. The prefactor in this expression depends on the DMI that drives the repulsion. The latter results in the spiral motion of the two skyrmions around each other, with the separation between them growing logarithmically with time. GS-9973 clinical trial When two skyrmions of the total topological charge $Q = 2$ are pushed close to each other, the discreteness of the atomic lattice makes them collapse into one skyrmion of charge $Q = 1$ below a critical separation. Experiment is proposed that would allow one to measure the interaction between two skyrmions by holding them in positions with two magnetic tips. Our findings should be of value for designing topologically protected magnetic memory based upon skyrmions.Ternary oxides/sulfides have long been investigated as promising electrode materials for charge storage applications. However, it is important to rationally design nanostructured hybrid composites for superior charge storage performance as electrodes in devices. In this work, MoO3@NiCo2S4 hybrid composites materials are synthesized by hydrothermal method followed by annealing at different temperatures. The charge storage properties of these materials are tested by cyclic voltammetry, galvanostatic charge-discharge curves and electrochemical impedance spectroscopy. It is found that the structure of the hybrid composite material not only assists the electron and charge transportation but also precisely control the volume expansion during redox reactions, contributing to superior electrochemical behavior. Among all the electrodes, the electrode fabricated with MoO3@NiCo2S4 composite material annealed at 400 °C (MoO3@NiCo2S4-400) is the best for charge storage application. At 400 °C MoO3 spreads as a thin layer of surface polymeric molybdates on NiCo2S4 as seen in the XRD pattern. Significantly, it delivers highest capacitance of 1622 F g‒1 at 1 A g‒1 in 2 M aqueous KOH electrolyte compared to other hybrid composite electrodes, NiCo2S4 (962 F g‒1), MoO3@NiCo2S4-500 (1412 F g‒1) and MoO3@NiCo2S4-600 (970 F g‒1) under the same measurement conditions. Furthermore, MoO3@NiCo2S4-400 hybrid electrode shows better cyclic stability with 93% capacitance retention after 3000 charge-discharge cycles at 8 A g‒1. The synergistic effect of two components and annealing temperature plays important role in enhancing the charge storage performance. This work shows the importance of synthesis temperature on the functional character of ternary sulfide/oxide composite materials for charge storage applications.Organic plastic scintillation detectors (PSDs) are known to produce less light per absorbed dose in highly dense radiations in comparison with e.g.60Co gamma beams. This so-called ionization density quenching can be experimentally determined by comparison of the scintillator output with the absorbed dose established with a reference detector. The hypothesis of this work was that a newly developed small-core graphite calorimeter (core size ø5mm × 7mm) can be used as reference for such measurements. The potential benefit of a calorimetric reference would be to have a robust and accurate reference with well-understood dosimetry properties even in high-intensity FLASH beams. As a first step, the hypothesis was tested by comparing previously established quenching parameter estimates for the BCF-60 scintillating material with data obtained with the new instrument at different depths along the central axis of a 170 MeV scanned proton beam. After the calorimetric measurements, scintillator measurements were acquired under equivalent conditions by positioning the PSD in a replica graphite core nominally identical to the core used for calorimetry.