Farrellbrandt9570
Suicide-specific rumination, characterized by perseveration on and difficulties disengaging from suicidal thoughts and ideas, has been linked to increased suicide risk; however, previous studies were limited by the use of a cross-sectional design and relatively lower risk samples. This study aimed to replicate and extend previous findings by examining the short-term longitudinal association between suicide-specific rumination and suicidal intent, controlling for numerous robust covariates, in a sample of community-based adults at high risk for suicide, who were recruited from suicide-related forums online. Ninety-one adults with significant suicidal ideation (Mage = 27.03, SD = 8.64; 53.8% female, 44.0% male, 1.1% non-binary, 1.1% transgender female) completed brief online self-report measures at six time-points, each three days apart. Multilevel modeling analyses indicated that suicide-specific rumination was associated with suicidal intent, above and beyond suicidal ideation, perceived burdensomeness, thwarted belongingness, agitation, insomnia, nightmares, and sociodemographic characteristics. Further, a lagged model demonstrated that suicide-specific rumination predicted subsequent time-point suicidal intent, controlling for current suicidal intent and all other covariates. Overall, these findings suggest that perseverating on one's suicidal thoughts may serve as a proximal factor that increases suicide risk. Future investigations should explore potential mechanisms of this association, as well as interventions that may reduce suicide-specific rumination.
Hysterectomy has been associated with increased thyroid cancer risk but whether this reflects a biological link or increased diagnosis of indolent cancers due to greater medical contact remains unclear.
We recruited 730 women diagnosed with thyroid cancer and 785 age-matched population controls. Multivariable logistic regression was used to assess the association overall, and by tumour BRAF mutational status as a marker of potentially higher-risk cancers. We used causal mediation analysis to investigate potential mediation of the association by healthcare service use.
Having had a hysterectomy was associated with an increased risk of thyroid cancer (odds ratio [OR] = 1.45, 95 % confidence interval [CI] 1.07-1.96). When stratified by indication for hysterectomy, the risk appeared stronger for those who had a hysterectomy for menstrual disorders (OR = 1.67, 95 % CI 1.17-2.37) but did not differ by tumour BRAF status. Approximately 20 % of the association between hysterectomy and thyroid cancer may be mediated by more frequent use of healthcare services.
The observed increased risk of thyroid cancer among those with hysterectomy may be driven, at least partly, by an altered sex steroid hormone milieu. More frequent healthcare service use by women with hysterectomy accounts for only a small proportion of the association.
The observed increased risk of thyroid cancer among those with hysterectomy may be driven, at least partly, by an altered sex steroid hormone milieu. buy Vorinostat More frequent healthcare service use by women with hysterectomy accounts for only a small proportion of the association.The foreign-body reaction (FBR) caused by the implantation of synthetic polymer scaffolds seriously affects tissue-biomaterial integration and tissue repair. To address this issue, we developed a cell membrane-biomimetic coating formed by "click"-mediated liposome immobilization and fusion on the surface of electrospun fibers to mitigate the FBR. Utilization of electrospun polystyrene microfibrous scaffold as a model matrix, we deposited azide-incorporated silk fibroin on the surface of the fibers by the layer-by-layer assembly, finally, covalently modified with clickable liposomes via copper-free SPAAC click reaction. Compared with physical adsorption, liposomes click covalently binding can quickly fuse to form lipid film and maintain fluidity, which also improved liposome stability in vitro and in vivo. Molecular dynamics simulation proved that "click" improves the binding rate and strength of liposome to silk substrate. Importantly, histological observation and in vivo fluorescent probes imaging showed that liposome-functionalized electrospun fibers had negligible characteristics of the FBR and were accompanied by many infiltrated host cells and new blood vessels. We believe that the promotion of macrophage polarization toward a pro-regenerative phenotype plays an important role in vascularization. This bioinspired strategy paves the way for utilizing cell membrane biomimetic coating to resist the FBR and promote tissue-scaffold integration.Slender objects are long and thin objects. Existing object detection networks are not specially designed for detecting slender objects. We propose a method to detect slender objects. We represent slender objects with a keypoint-displacement pattern instead of using axis-aligned bounding boxes, avoiding problems like orientation confusion and wrong elimination. In our network, three parallel branches predict keypoint heatmaps, displacement vector field, and displacement uncertainty heatmap respectively. We add the uncertainty branch to enable our network to give uncertainty together with detection results. The predicted uncertainty provides a continuous criterion to evaluate whether detection results are reliable. In addition, the uncertainty branch can lower the weight of ambiguous training samples, leading to more accurate detection results. We employ our proposed method in two typical practical applications. Edges of electrode sheets and pins of electronic chips are correctly detected as slender objects. Manufacturing quality is evaluated through analyzing the detection results, including keypoint number, displacement property, and uncertainty value.
To evaluate the effectiveness of including nutritional and food properties information in a university canteen in Salamanca (Spain) to promote healthy eating behaviours.
Experimental and correlational cross-sectional study.
University Dining Hall of Salamanca (Spain).
In the experiment, information was collected on the choice of 1122 menus by university students. The questionnaire was answered by 48 university students who participated in the experiment.
Mixed methodology (field experiment and online questionnaire). The independent variable was the inclusion or not of nutritional information from the menus. The questionnaire was used to evaluate the students' attitude towards this type of tool.
The experiment shows an improvement in the diet of university students with the inclusion of information elements that appeal to the healthiest choice, increasing their consumption of fruit, vegetables, legumes, fish and white meat. The students surveyed showed a high degree of receptivity to these health promotion tools.
