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Romantic attachment rejection (RAR) is a highly prevalent phenomenon among young adults. Rejection by a romantic attachment figure can be a painful and incapacitating experience with lasting negative mental health sequelae, yet the underlying neurobiology of RAR is not well characterized. We systematically reviewed functional neuroimaging studies of adult RAR. Four functional magnetic resonance imaging (fMRI) studies that measured participants' responses to real or imagined RAR and met inclusion criteria were evaluated. These included studies were published between 2004 and 2018. Brain activity in adult participants with an RAR appears to be influenced by the stimulus used to elicit a reaction as well as by attachment styles. Brain regions that show a significant change in activation following a rejection stimulus include cortical regions (cingulate, insular, orbitofrontal, and prefrontal), and subcortical regions (angular gyrus, hippocampus, striatum, tegmental area, and temporal pole) and correspond to (i) pain, distress, and memory retrieval; (ii) reward, romantic love, and dopaminergic circuits; and (iii) emotion regulation and behavioural adaptation. Further neuroimaging studies of adult RAR, as moderated by stimulus and attachment style, are needed to better understand the underlying neurobiology of RAR.Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by the presence of antiphospholipid antibodies in patients with arterial or venous thrombosis or pregnancy complications. This paper reports a case of a 31-year-old woman who died after she underwent C-section for intrauterine fetal death (IUFD) at the 25th week of gestation. The patient was complaining of pelvic pressure, swelling in the lower limbs, and pain in the groin, one big toe, and both wrists. She had low platelet count, liver abnormalities, and proteinuria. After IUFD, she complained of flank pain and headache. After discharge from the hospital, the patient had constant headaches and 5 days later woke up with hemiplegia. CT scan showed cerebral hemorrhage in the right hemisphere and thrombosis in the left hemisphere. The LA and APS tests were positive. The main cause of death was hemorrhage and infarction in the brain.To perform a review on patients with primary antiphospholipid syndrome (APS) who developed an aneurysm. A review of articles published in PubMed/MEDLINE, LILACS, and SciELO dating from 1966 to October 2020 was conducted using the following search words "Antiphospholipid syndrome" and "aneurysm." No language limitation was applied. This review includes 10 articles on APS patients and aneurysms entailing 14, including our additional case. Age varied from 20 to 76 years old, and female sex was predominant and presented in 54%. The arterial vessels compromised were aorta (n = 6), coronary (n = 2), hepatic (n = 2), renal (n = 2), middle cerebral artery (n = 2), and then splenic, superior mesenteric, pancreatic, retinal, jejunal, carotid, and pulmonary. Frequencies of antiphospholipid antibodies were described as follows lupus anticoagulant (n = 6), anti-beta2-glycoprotein I (n = 4), IgG and IgM anticardiolipin (n = 3), IgG anticardiolipin (n = 3), and antiphosphatidylserine (n = 2). The presence of APS manifestations was distributed as deep venous thrombosis (n = 4), recurrent abortions (n = 4), pulmonary embolism (n = 3), stroke, or transitory ischemic accident (n = 3), and then limb ischemia and thrombocytopenia. The therapies used in these patients were warfarin, antiplatelet agent, vascular surgery, heparin, hydroxychloroquine, coil embolism, and intravenous immunoglobulin. Regarding outcomes, 5 patients were alive, and 3 were dead. This article reviewed all published cases on APS and aneurysm and showed that women who presented with abortions and deep venous thromboses with a lupus anticoagulant are those patients more commonly affected by aneurysms in APS.The decline of milk production in crossbred cattle during the onset of summer was evaluated using lactation records of the cows (n = 48) maintained at the Livestock Research Station, Thiruvazhamkunnu, for the period between January 2019 and March 2019. Climate data were obtained from an automatic weather station maintained on the campus. The temperature-humidity index (THI) was used to assess the thermal stress on animals. Values varied between 70.78 and 83.93 during the study period, indicating that the cows were exposed to mild and moderate stress. Highly significant negative correlations (p  less then  0.01) were observed between the average temperature, THI, and milk production. Linear, logarithmic, power, and polynomial models linking milk production and THI were used to fit the data. The coefficient of determination (R2) in general exceeded 0.85 and these equations could be used to model the drop in milk production or predict production loss due to thermal stress. The rate of decline in daily milk production observed in the study was 2.13% per unit increase in THI. A general linear model that included THI, parity, and the stage of lactation as independent variables, and milk production as a response variable, was also tested. Parity and stages of lactation were observed to influence forenoon and afternoon milk production significantly (p  less then  0.01). The temperature-humidity index also had a significant effect on forenoon milk production (p  less then  0.05) and afternoon milk production (p  less then  0.01).

To assess the association between low hemoglobin (Hb) level and development of contrast-induced nephropathy (CIN) for hepatocellular carcinoma (HCC) patients after transarterial chemoembolization (TACE).

A retrospective analysis was performed on 284 patients undergoing 503 consecutive sessions of TACE. Propensity score matching (PSM) analysis was used to reduce the influence of the difference in variables in normal and low hemoglobin groups. Risk factors of CIN were assessed by univariate and multivariate logistic regression analysis. The relation between Hb level and CIN development was analyzed by receiver operating characteristic (ROC) curve.

CIN developed in 5.6% patients after TACE. Multivariate logistic regression analysis showed that hypertension, Hb and serum creatinine (Scr) were independent risk factors for the development of post-TACE CIN. 5-(N-Ethyl-N-isopropyl)-Amiloride order Grouped by normal or low Hb, the incidence of CIN was 14.6% (16/110) in the low Hb group and 3.4% (4/116) in the normal Hb group after PSM. Multivariate logistic regression analysis revealed that Hb, lymphocyte count, and neutrophil to lymphocyte ratio (NLR) were independent risk factors for the development of post-TACE CIN.

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