Hvidbergholbrook8839

Introduction Although one of the most common monogenic late-onset neurodegenerative disorders, fragile-X-associated tremor/ataxia syndrome (FXTAS) is still underdiagnosed. The aim of the present study was to estimate the frequency of premutation carriers in patients with unexplained degenerative ataxias, action tremor or parkinsonism, and action tremor with or without associated cognitive impairment.Methods The study comprised 100 consecutive patients with the disease onset >49 years who had any form of unexplained action tremor, cerebellar ataxia, followed by parkinsonism with or without incipient dementia, and in whom the FMR1 repeats size was determined.Results Premutation in the FMR1 was identified in two patients (2%) the first, male patient had 83 CGG repeats and the second, female patient had 32 and 58 CGG repeats.Discussion/Conclusion FXTAS was relatively rare among older patients with unexplained ataxia and action tremor, with or without parkinsonism and/or cognitive impairment. Tremor and ataxia were major clinical features in our two patients, although parkinsonism, autonomic dysfunction and psychiatric problems might be an important part of the spectrum. Probable FXTAS should be considered in the differential diagnosis of patients with unexplained action tremor and ataxia, and undetermined parkinsonism, especially when there was a positive family history for involuntary movement disorders in other family members and/or autism spectrum disorders in younger cousins.

To investigate the ablation efficiency of Super-pulse Thulium fiber laser (SPTFL) with different laser setting and fiber usage.

SPTFL machine was attached with different fibers. Artificial stones were fixed in water, while laser fiber was driven on a platform for ablation. Pulse energy, frequency, fiber moving speed, fiber-to-stone distance and fiber size were adjusted in each trial. The cross-sectional area of craters on the lateral stone surface was measured for comparison of ablation rate, combined with fiber moving speed.

There was a trend that the ablation rate increased as pulse energy or frequency increased. Selleckchem SSR128129E When pulse energy was set as 0.2 J and frequency was increased from 50 HZ to 150 HZ, the cross-sectional area of the crater was enlarged from 0.21 mm2 to 0.37 mm2 (p < 0.05); when the frequency was set as 100 HZ and pulse energy was increased from 0.1 J to 0.3 J, the crater was enlarged from 0.10 mm2 to 0.45 mm2 (p < 0.05). Furthermore, energy demonstrated greater impact on ablation rate and the crater was enlarged from 0.20 mm2 in 0.1 J × 300 HZ group to 0.44 mm2 in 0.3 J × 100 HZ group (p < 0.05). Then fiber was set at different moving speed with the same laser setting, the ablation rate of 3 mm/s group was 3.64 times higher than 0.5 mm/s group (p < 0.05). Ablation diminished as fiber-to-stone distance grew up. 200 μm fiber produced thinner and deeper fissure than 272 µm and 550 µm fiber, and the ablation rate was the highest for 200 μm fiber.

Pulse energy is a more important factor in influencing ablation efficiency compared with frequency. Closer fiber-to-stone distance, faster fiber movement and smaller fiber size increase ablation efficiency.

Pulse energy is a more important factor in influencing ablation efficiency compared with frequency. Closer fiber-to-stone distance, faster fiber movement and smaller fiber size increase ablation efficiency.Humans exhibit sexually-based vocal dimorphisms, providing information about peoples' intrinsic states. Studies indicate that voice pitch predicts relationship quality; however, none have explored its effects on relationship maintenance. We explored the association between sexually dimorphic vocal properties [voice pitch, measured by fundamental frequency (F0) and F0 variation, the within-subject SD in F0 across the utterance (F0-SD)], attachment styles, and communication patterns among Chinese heterosexuals in romantic relationships. Men's F0-SD positively correlates with constructive communication pattern and negatively correlates with avoidant attachment style. No significant correlations are found for women. These findings suggest that men with masculine voices are more avoidantly attached, using avoidant communications. Furthermore, they show that voice may play a crucial role in and be an important morphological index of human mating relationships.

The aim of this study was to evaluate sexual function in male and female COPD (chronic obstructive pulmonary disease) patients and identify associated factors. Methods This is a cross-sectional study on 52 COPD patients treated at an outpatient pneumology service of a referral hospital in Northeastern Brazil. Information was collected on demographic, clinical and spirometric variables and exercise capacity. The following instruments and scores were used modified Medical Research Council (mMRC) for dyspnea, SF-36 for quality of life (QoL), the Beck Depression and Anxiety Inventory, Male and Female Sexual Quotient. Results Sexual function was satisfactory/excellent in 17% (9/52) and poor/absent in 82% (43/52). Patients with poor/absent sexual function tended to have lower scores on the domain mental health summary score of SF-36 (p = 0.007) and higher anxiety and depression scores than patients with satisfactory/excellent sexual function (p = 0.02 and p = 0.01). In the multivariate analysis, patients with higcores on the domain mental health summary score of SF-36 (p = 0.007) and higher anxiety and depression scores than patients with satisfactory/excellent sexual function (p = 0.02 and p = 0.01). In the multivariate analysis, patients with high depression scores displayed a greater likelihood of poor/absent sexual function (OR = 1.13; 95% CI = 1.02-1.25). Conclusion COPD patients presented a high rate of sexual dysfunction and compromised sexuality was associated with depression.Women living with HIV (WLWH), experience disproportionate rates of violence, along with suboptimal HIV health outcomes, despite recent advancements in HIV treatment, known as antiretroviral therapy (ART). The objectives of this study were to (a) describe different types of support needed to take ART and (b) investigate the social and structural correlates associated with needing support for ART adherence among WLWH. Data are drawn from Sexual health and HIV/AIDS Women's Longitudinal Needs Assessment, a community-based open research cohort with cisgender and transgender WLWH, aged 14+ who live or access HIV services in Metro Vancouver, Canada (2014-present). Baseline and semi-annual questionnaires are administered by community interviewers alongside a clinical visit with a sexual health research nurse. Bivariate and multivariable logistic regression using generalized estimating equations and an exchangeable working correlation matrix was used to model factors associated with needing supports for ART adherence.