Sherrillmccann9621

Phytochemical investigation of the rhizome of Ligusticum chuanxiong Hort led to the isolation and identification of three new compounds, chuanxiongoside A, (2E,4E)-8-(6-O-inositolyl)-8-oxo-2,7-dimethyl-octadienoic acid (2), chuanxiongoside C (3). The structures of these compounds were unambiguously established by HR-ESI-MS, UV, IR, CD, NMR spectral data and comparison to reported data. All the isolated compounds (1-3) were investigated for their inhibitory effects on nitric oxide (NO) production in LPS-induced RAW 264.7 cells. All compounds showed excellent inhibition of NO production stronger than curcumin. [Formula see text].Social support from a spouse, long-term partner, or someone who provides emotional or instrumental support may protect against consequences of aging, including mediating behavioral stress reactivity and altering neurobiological process that underlie short-term stress responses. Therefore, long-term social bonding may have behavioral and neurobiological benefits. The socially monogamous prairie vole provides a valuable experimental model for investigating the benefits of long-term social bonds on short-term stress reactivity in aging animals, given their unique social structure of forming enduring opposite-sex bonds, living in family groups, and bi-parental rearing strategies. Sepantronium Male-female pairs of long-term, cohabitating prairie voles were investigated for short-term behavioral and neuroendocrine stress reactivity following either long-term social pairing (control), or a period of social isolation. In Experiment 1, social isolation was associated with altered behavioral reactivity to an acute swim stressor, an from a long-term social partner disrupted behaviors and short-term stress responses, whereas living with a long-term partner protected against these disruptions. This research is important for our understanding of the benefits of social support on stress responses as we age.Social isolation and sedentary behaviour are common in residential aged care facilities (also known as nursing homes or long-term care). Use of new technologies such as virtual and augmented reality are currently under investigation for their potential to provide exciting and engaging activities for older people in residential aged care facilities. However, there is limited evidence on whether these technologies can promote physical activity in a small group setting for people with cognitive impairment. Using mixed methods, we examined the use of a virtual cycling experience in a sample of 10 participants with cognitive impairment living in residential aged care facilities. In a randomised crossover design, participants engaged in a 25-minute, self-paced, facilitated seated virtual cycling experience and a time-matched seated physical activity session in groups of five. All participants completed a brief pre- and post-intervention mood questionnaire. Video analysis was used for both conditions to compare levernative to usual activities, which might encourage higher levels of physical activity in residential aged care facilities.

Protein nanocarriers offer advantageous delivery platforms for anti-cancer drugs, provided by their biocompatibility, high drug loading capacity, and their ability to encapsulate hydrophobic active therapeutics. However, the conventional fabrication techniques of protein nanoparticles (NPs) often suffer from incorporation of considerable amounts of toxic solvents and crosslinking agents which may result in significant toxicity or compromise the drug stability. Therefore, novel strategies were proposed to induce non-covalent self-assembly of proteins by exploiting hydrophobic interactions or manipulation of disulfide bonds to produce nontoxic crosslinker-free drug-loaded protein NPs. Thermal mediated unfolding, the use of reducing agents, modulation of pH and ionic strength, chemical-induced denaturation as well as photochemical methods can be efficiently utilized to induce the protein self-assembly process.

In this review, we highlight the novel approaches used in the development of non-covalent protein-drug nano-assemblies, formulation factors, their implications, limitations, and treatment outcomes as well as future challenges.

Formulation of protein-drug nanocarriers via non-covalent self-assembly can be advantageous as a promising strategy for efficient and safe tumor-targeted delivery of anti-cancer drugs compared to the conventional nano-fabrication technologies.

Formulation of protein-drug nanocarriers via non-covalent self-assembly can be advantageous as a promising strategy for efficient and safe tumor-targeted delivery of anti-cancer drugs compared to the conventional nano-fabrication technologies.

Alpha emitters present several advantages for cancer therapy. The radiopharmaceutical

Ra-dichloride has been recently introduced for the targeted alpha therapy (TAT) of metastastic castration-resistant prostate cancer (mCRPC). However, since

Ra-dichloride targets only skeletal lesions, its use in clinical practice is recommended only in subjects without visceral metastases. To overcome this, several efforts have been made to develop radiopharmaceuticals suitable for TAT and specifically directed toward the biomarker prostate specific membrane antigen (PSMA), overexpressed by both skeletal and visceral metastases from mCRPC.

The radiobiological principles concerning TAT applications are covered, with particular emphasis on its pros and cons, especially in comparison with beta-emitter radionuclide therapy. Furthermore, the role of PSMA as a theranostic target for imaging and therapy is reviewed. Lastly, the pre-clinical and clinical applications of TAT through 225Actinium (

AC) and 213Bismuth (

Bi) are discussed.

PSMA-based TAT holds the promise of becoming a powerful tool for the management of mCRPC. Nevertheless, several issues have still to be addressed, especially concerning TAT toxicity. Furthermore, several efforts have to be made for identifying the more adequate alpha-emitter (

Ac vs

Bi) with a view to the patient's tailored therapeutic approach.

PSMA-based TAT holds the promise of becoming a powerful tool for the management of mCRPC. Nevertheless, several issues have still to be addressed, especially concerning TAT toxicity. Furthermore, several efforts have to be made for identifying the more adequate alpha-emitter (225Ac vs 213Bi) with a view to the patient's tailored therapeutic approach.