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Objectives To compare different methods in calculating the corneal radius (R) to be used in case of intraocular lens power calculations when it is immeasurable. Methods The right eyes of 1,960 patients were randomly divided into 2 equal groups. The first group of right eyes (group A) was divided in three groups according to the axial length (AL) (≤21.99 mm, between 22 and 24.99 mm, and ≥25 mm). In these groups, the correlation between the AL and the corneal radius (R) provided three different regression formulas. The second group of right eyes (group B) was used to test the following methods of estimating the R the regression formulas determined from group A, formula from Logan et al., formula from Stenström, the mean R calculated from group A, and the fellow eye group B. A Student paired T test was used for the statistical evaluation. Results In case of AL≤21.99, the best results have been obtained with the fellow eye R, followed by either the regression formula or the mean R from group A (mean=0.00±0.09 mm, P=0.94, mean=0.05±0.21 mm, P=0.05, mean=0.05±0.22 mm, P=0.08, respectively). In case of AL between 22 and 24.99 mm, the best results have been obtained with the fellow eye R, followed by either the regression formula or the mean R from group A (mean=-0.01±0.09 mm, P=0.38, mean=0.01±0.21 mm, P=0.12, mean=0.01±0.24 mm, P=0.18, respectively). In case of AL≥25 mm, the best results have been obtained with the fellow eye R, followed by either the regression formula or the mean R from group A (mean=-0.003±0.08 mm, P=0.94 mean=-0.004±0.25 mm, P=0.85, mean=-0.004±0.25 mm, P=0.85, respectively). Conclusions The new calculated regression formulas seem to represent a reliable method to calculate the R when it is undetectable, as in case of corneal dystrophies.The COVID-19 pandemic and the response to have resulted in an increase in sales activity levels on darknet markets during the first three months of 2020, mainly related to cannabis products. One key question is whether more people will become used to this form of purchasing their drugs and will they continue with it post COVID-19 lockdown. As one-to-one encrypted communication services or social media apps are increasingly being used, monitoring and interdiction will become much more challenging.Objective To evaluate an advanced extracellular matrix made of ovine forestomach matrix (OFM) for healing a variety of wound types. Methods Participants were enrolled from inpatient, outpatient, and home health care settings. The OFM was used to treat all wounds and applied to the wound bed every 3 to 7 days until closure. Results Researchers enrolled 29 participants with 33 wounds. Average time to wound closure was 8.2 weeks, the percentage of wounds that reduced in size by 50% or more at 4 weeks was 64%, the average wound area reduction at 4 weeks was 66%, and 73% of wounds had closed at 12 weeks. No adverse effects were observed. Conclusions This represents the first Canadian evaluation of OFM for the treatment of wounds and the positive healing outcomes observed could support more widespread adoption of this matrix.The challenges imposed by the COVID-19 pandemic become amplified in the setting of non-intubated patients with obstructive sleep apnea. Unlike the closed system that characterizes an intubated patient attached to a respiratory circuit, non-invasive ventilatory support threatens an increased risk of permeating the clinical workspace with airborne viral particles. Patients with sleep apnea may mandatorily require non-invasive ventilation strategies to see them through a respiratory illness. In this infographic, the considerations and general principles of managing non-invasive ventilation in such a scenario are outlined. The reader is encouraged to review the article in its entirety for a full depth of understanding.Late-onset focal dermal elastosis is a clinical mimic of pseudoxanthoma elasticum that lacks associations with systemic disease. Although initial reports asserted that the disorder occurs only in the elderly, a growing body of case reports document cases in patients as young as 39 years. We present a case of a 59-year-old woman with this disorder. To reflect the broad age range of patients affected by this disorder, we propose the term "focal dermal elastosis."Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant eosinophilic infiltrate, such as bullous pemphigoid, pemphigoid gestationis, and pemphigus vegetans, may show them. However, it is rare to find them in predominant neutrophilic bullous dermatoses such as linear immunoglobulin A. We present a 60-year-old man with a history of chronic urticaria, which presented a bullous disease after an acute parvovirus B19 infection. The histological findings showed an exceptional linear immunoglobulin A bullous dermatosis with an eosinophilic infiltrate in the dermis forming "flame figures." The clinical and histopathological findings for this entity may be identical to those of other dermatoses. Sotuletinib For this reason, combining these findings with direct immunofluorescence analysis is essential for correct diagnosis of this bullous disease.We describe the association of balanitis xerotica obliterans and differentiated penile intraepithelial neoplasia (PeIN) with dermal elastosis and "bramble-bush" elastic fibers in a diabetic patient with no history of penicillamine intake. An 84-year-old man presented with urethral obstruction syndrome that required postectomy, meatotomy, and foreskin excision. Histopathological examination revealed changes of lichen sclerosus and differentiated PeIN. Orcein staining showed striking dermal elastosis and transepidermal elimination of elastic fibers. At higher magnification, multiple serrations and buds arising from the borders of the elastic fibers were observed giving the so-called bramble-bush appearance. Balanitis xerotica obliterans is considered a premalignant disease, and 14% of patients have evidence of PeIN. The differentiated subtype can be difficult to diagnose because of the minimal basal cell atypia, so a striking dermal elastosis, which may even occur before the neoplasm becomes invasive, may facilitate its diagnosis.

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