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edicting the benefit from supplementing PubMed with Embase to retrieve relevant publications to include in a review.

The purpose of this study was to examine the colonization and tubular invasion of Enterococcus faecalis in minimally altered canal walls. We hypothesized that age, axial directions (buccolingual or mesiodistal), regions (apical, midroot, or cervical), and disinfection treatment (sodium hypochlorite or autoclave) would impact bacterial colonization and invasion patterns.

Single roots of extracted teeth from 2 age groups (≤30 years old and ≥60 years old) were challenged with bacteria for 2 weeks. Colonization on the canal walls in 3 regions was evaluated with scanning electron microscopy. The prevalence of tubular invasion in the axial directions in 3 regions was examined with confocal laser scanning microscopy. The data were analyzed using the GLIMMIX procedure in SAS software (SAS Institute Inc, Cary, NC) with a Tukey adjustment for comparisons.

Bacteria successfully colonized and invaded tubules in 2 weeks. The apical region in the ≥60-year age group was the least infected. A significantly higher invasion prevalence in a buccolingual (B/L) than a mesiodistal (M/D) direction was detected in both age groups and in all 3 regions. The ≤30-year age group had a significantly higher prevalence of tubular invasion than the ≥60-year age group in the B/L and M/D direction, respectively. Sodium hypochlorite treatment significantly impacted bacterial colonization and invasion in more calcified areas.

Our data support a more conservative enlargement of the apical region of older teeth. An emphasis in a B/Ldirection rather than an M/D direction is recommended for debridement.

Our data support a more conservative enlargement of the apical region of older teeth. An emphasis in a B/L direction rather than an M/D direction is recommended for debridement.

To estimate the excess healthcare use and work disability attributable to knee osteoarthritis (OA) in the first 5years following diagnosis.

Among individual aged 40-80 years who resided in Skåne on 31

December 2008, we identified those with a main diagnosis of knee OA during 2009-2014 and no previous diagnosis of any OA from 1998 (n=16,888). We created a comparison cohort matched (11) by sex, age, and municipality from individuals with no OA diagnosis (at any site) during 1998-2016. We compared healthcare use and net disability days for 60 months following diagnosis between the two groups. We applied a survival-adjusted regression technique controlling for sociodemographic characteristics as well as pre-diagnosis outcome and comorbidity.

The estimated 5-year incremental effects of knee OA per-patient were 16.8 (95% CI 15.8, 17.7) healthcare consultations, 0.7 (0.4, 1.1) inpatient days, 420 (372, 490) defined daily dose of prescribed medications, and 21.8 (15.2, 30.0) net disability days. selleck Primary care consultations constituted about 73% of the excess healthcare consultations. Most of these incremental effects occurred in the first year after diagnosis. Better survival in the knee OA group accounted for 0.7 (95% CI 0.5, 0.8) and 1.4 (0.7, 2.6) of the excess healthcare consultations and net disability days, respectively. Both estimated total and incremental resources use were generally greater for women than men with knee OA.

Knee OA was associated with considerable excess healthcare use and work disability independent of pre-diagnosis resources use, comorbidity, and sociodemographic characteristics.

Knee OA was associated with considerable excess healthcare use and work disability independent of pre-diagnosis resources use, comorbidity, and sociodemographic characteristics.

The goal of this study was to analyze the relationship between osteoarthritis and the incidence of fracture in men and women aged ≥18 years followed in general practices in the United Kingdom.

This study included patients aged ≥18 years who had received an initial diagnosis of osteoarthritis in one of 256 general practices in the United Kingdom between January 1997 and December 2016 (index date). Patients without osteoarthritis were matched (11) to those with osteoarthritis by sex, age, index year, diabetes, dementia, corticosteroid therapy, and practice. For patients without osteoarthritis, the index date was a randomly selected visit date between 1997 and 2016. The association between osteoarthritis and the incidence of fracture was investigated using Kaplan-Meier curves and conditional Cox regression analyses.

This retrospective cohort study included 129,348 patients with osteoarthritis and 129,348 patients without osteoarthritis [60.1% women; mean (standard deviation) age 63.7 (14.0) years]. After 10 years of follow-up, 12.1% of individuals with osteoarthritis and 7.7% of those without osteoarthritis had suffered at least one fracture (log-rank P-value<0.001). There was a positive and significant association between osteoarthritis and fracture in the overall sample [hazard ratio (HR)=1.55, 95% confidence interval (CI)=1.50-1.60]. These findings were corroborated in all sex, age, and osteoarthritis joint site subgroups.

Intervention is urgently needed to reduce the risk of fracture in adults with osteoarthritis, and further research is warranted in order to gain more of an insight into the mediators involved in the relationship between osteoarthritis and fracture.

Intervention is urgently needed to reduce the risk of fracture in adults with osteoarthritis, and further research is warranted in order to gain more of an insight into the mediators involved in the relationship between osteoarthritis and fracture.

To assess the potential of near-infrared spectroscopy (NIRS) for in vivo arthroscopic monitoring of cartilage defects.

Sharp and blunt cartilage grooves were induced in the radiocarpal and intercarpal joints of Shetland ponies and monitored at baseline (0 weeks) and at three follow-up timepoints (11, 23, and 39 weeks) by measuring near-infrared spectra in vivo at and around the grooves. The animals were sacrificed after 39 weeks and the joints were harvested. Spectra were reacquired ex vivo to ensure reliability of in vivo measurements and for reference analyses. Additionally, cartilage thickness and instantaneous modulus were determined via computed tomography and mechanical testing, respectively. The relationship between the ex vivo spectra and cartilage reference properties was determined using convolutional neural network.

In an independent test set, the trained networks yielded significant correlations for cartilage thickness (ρ=0.473) and instantaneous modulus (ρ=0.498). These networks were used to predict the reference properties at baseline and at follow-up time points.