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Mental disorders can take different forms and will generally have an impact on the learning of people who suffer from them. Taking more time, taking breaks, giving clear instructions and reassurance are all key elements of the support which must be provided to these people in their vocational training.Deaf and a health professional, so what? For 22-year-old Emma, disability is no obstacle to achieving her ambitions. Although far from easy, her experience has so far been positive. Panobinostat cell line The key? Adapted support, enlightened trainers and unwavering motivation. Interview."Dys" disorders must be taken into account by trained teams in order for the people concerned to be able to undertake their training of choice. Learning is not easy, but neither is it impossible. With adapted support and a detailed analysis of the needs and tools required, it is possible to envisage working in the health care sector.People with a disability can benefit from adapted training in a vocational rehabilitation centre. Several sectors of activity are accessible, including health care. The experience of the Mulhouse team highlights all the challenges of these training courses which are "not quite like any other".Despite legal obligations, the employment rate among disabled workers in the public sector is still below the required 6%. However, the new social model introduced by the law of 11 February 2005 is based on the premise that "being in a situation of disability in a workplace does not mean being unfit to work". In fact, the notions of universal accessibility, environment, right to adaptations and social representations must be discussed in the area of occupational training.There is often confusion between the notion of disability in everyday life in society and the more specific notion of disability in the workplace. A health problem cannot be considered as a disability in everyday life, even if it makes life less agreeable, but can become one in the context of a professional activity. What and who exactly do we mean when we refer to disabled workers? Here we explore the different types of disabilities and their effects on employment as well as the tools currently available.The place of families in intensive care is still too often underestimated. However, the involvement of family members would have multiple benefits for patients, but also for those around them. Family participation is a promising concept that needs to be studied on the ground and on a large scale, in order to prove itself and guide health professionals in their daily practice.France was strongly impacted by the COVID-19 pandemic with nearly30.000 deaths at the end of June 2020. Referent in infectiology, Begin military teaching hospital has contributed to the management of infected patients. The hospital pharmacy has been fully mobilized in the management of the crisis.Homology-directed repair (HDR) of a DNA break allows copying of genetic material from an exogenous DNA template and is frequently exploited in CRISPR-Cas9 genome editing. However, HDR is in competition with other DNA repair pathways, including non-homologous end joining (NHEJ) and microhomology-mediated end joining (MMEJ), and the efficiency of HDR outcomes is not predictable. Consequently, to optimize HDR editing, panels of CRISPR-Cas9 guide RNAs (gRNAs) and matched homology templates must be evaluated. We report here that CRISPR-Cas9 indel signatures can instead be used to identify gRNAs that maximize HDR outcomes. Specifically, we show that the frequency of deletions resulting from MMEJ repair, characterized as deletions greater than or equal to 3 bp, better predicts HDR frequency than consideration of total indel frequency. We further demonstrate that tools that predict gRNA indel signatures can be repurposed to identify gRNAs to promote HDR. Finally, by comparing indels generated by S. aureus and S. pyogenes Cas9 targeted to the same site, we add to the growing body of data that the targeted DNA sequence is a major factor governing genome editing outcomes.A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2 pandemic. We describe the structure-based design of self-assembling protein nanoparticle immunogens that elicit potent and protective antibody responses against SARS-CoV-2 in mice. The nanoparticle vaccines display 60 SARS-CoV-2 spike receptor-binding domains (RBDs) in a highly immunogenic array and induce neutralizing antibody titers 10-fold higher than the prefusion-stabilized spike despite a 5-fold lower dose. Antibodies elicited by the RBD nanoparticles target multiple distinct epitopes, suggesting they may not be easily susceptible to escape mutations, and exhibit a lower bindingneutralizing ratio than convalescent human sera, which may minimize the risk of vaccine-associated enhanced respiratory disease. The high yield and stability of the assembled nanoparticles suggest that manufacture of the nanoparticle vaccines will be highly scalable. These results highlight the utility of robust antigen display platforms and have launched cGMP manufacturing efforts to advance the SARS-CoV-2-RBD nanoparticle vaccine into the clinic.Mosquito-borne viruses, or arboviruses, have been part of the infectious disease landscape for centuries, and are often, but not exclusively, endemic to equatorial and subtropical regions of the world. The past two decades saw the re-emergence of arthritogenic alphaviruses, a genus of arboviruses that includes several members that cause severe arthritic disease. Recent outbreaks further highlight the substantial public health burden caused by these viruses. Arthritogenic alphaviruses are often reported in the context of focused outbreaks in specific regions (eg, Caribbean, southeast Asia, and Indian Ocean) and cause debilitating acute disease that can extend to chronic manifestations for years after infection. These viruses are classified among several antigenic complexes, span a range of hosts and mosquito vectors, and can be distributed along specific geographical locations. In this Review, we highlight key features of alphaviruses that are known to cause arthritic disease in humans and outline the present findings pertaining to classification, immunogenicity, pathogenesis, and experimental approaches aimed at limiting disease manifestations.