Abernathymack1142

Background Irritable Bowel Syndrome (IBS) is one of the most commonly diagnosed gastrointestinal disorders, and its etiology is believed to be multifactorial. The role of smoking in the pathophysiology of IBS still remains inconclusive. Hence, we aim to investigate whether or not an association exists between smoking and IBS. Methods A cross-sectional study was conducted in a tertiary care hospital of Karachi. A sample size of 200 smokers and 200 non smokers was selected. A two-part self-reported questionnaire was administered to the participants and the diagnosis of IBS was based on the Rome III diagnostic criteria. All data were analyzed using the Statistical Package for the Social Sciences version 17. Statistical tests employed were Independent samples t-test, chi-square test, and binary logistic regression analysis to obtain Odds Ratio (OR) for various variables. A P-value less then 0.05 was considered statistically significant. Results Overall prevalence of IBS based on Rome III criteria was 9.5% (95% CI 9.45-9.60). Smoking was significantly found to be associated with IBS (P=0.002). Binary logistic regression analysis indicated that non-smokers were more likely to have IBS (Crude OR 3.00, 95% CI 1.23-7.30) than smokers, and females were more likely to have IBS (Crude OR 3.73, 95% CI 1.56-7.69) than males. Age, BMI, and food groups were not found to be significantly associated with IBS. Conclusion Our study concludes that IBS was more prevalent among non-smokers and amongst females. Further studies are required to firmly establish the role of smoking in IBS.Background Research ethics committees are comprised of policymakers, supervisors, and decision-makers and aim at increasing adherence to professional ethics standards in conducting health-related research. The existential philosophy of these committees is to preserve the patients' health, maintain and promote public trust in health care providers, protect the rights of both patients and health care providers, and promote organizational ethics. However, this task can be complex and challenging during a public health emergency. Research ethics committees set the standard of research in the emergency situations through defining which research has the potential to promote the quality of response to a public health emergency. Methods This study aims at collecting and classifying the valuable experiences of the research ethics committee members and reviewers during the early days of the COVID-19 epidemic in Iran University of Medical Sciences, one of the major universities in Tehran. It provides a basic understanding of the key concepts and challenges in reviewing and approving research by research ethics committees and the recommendations to overcome these challenging issues. Results To accelerate the review process of COVID-19 research proposals, the scientific, methodological and ethical review panel was integrated as a large committee called 'IUMS Corona Research Team'. Selleckchem Mitoquinone The first meeting was held on March 7, two weeks after the official announcement of the first case of the disease and is continued once a week. A total of 130 projects have been discussed and evaluated in this committee, among which 83 proposals were approved after modification. Conclusion An interdisciplinary approach supports a flexible and effective scientific and ethical review of research leading to more protection of research subjects as well as promotion in the treatment and management of the pandemic ahead.Background The worldwide emergence of future pandemics emphasizes the need to assess the pandemic resilient urban form to prevent infectious disease transmission during this epidemic. According to the lessons of the COVID-19 outbreak, this study aimed to review the current strategies of responding to pandemics through disaster risk management (DRM) to develop a pandemic-resilient urban form in phases of response, mitigation, and preparedness. Methods The research method is developed through desk study was used to explore the current literature of urban form responded to COVID-19 pandemic and for the text analysis; qualitative content analysis was applied developing a conceptual framework. Results To create pandemic resilient urban form, this study proposes principles to enhance the urban form resiliency in 3 scales of housing, neighborhoods/public spaces, and cities. These principles focus on the concept of resilient urban form from new perspectives focusing on the physical and nonphysical aspects of resilient urban form, which develops a new understanding of pandemics as a disaster and health-related emergency risks. The physical aspect of resiliency to epidemic outbreaks includes urban form, access, infrastructure, land use, and natural environment factors. Moreover, the nonphysical aspect can be defined by the sociocultural, economic, and political (including good governance) factors. By providing and enhancing the physical and nonphysical prerequisites, several benefits can be gained and the effectiveness of all response, mitigation, and preparedness activities can be supported. Conclusion As the pandemic's disruptions influence the citizens' lifestyle dramatically, the prominent role of place characteristics in the outbreak of pandemics, policymakers, urban planners, and urban designers should be pulled together to make urban areas more resilient places for epidemics and pandemics.Background The Bayesian methods have received more attention in medical research. It is considered as a natural paradigm for dealing with applied problems in the sciences and also an alternative to the traditional frequentist approach. However, its concept is somewhat difficult to grasp by nonexperts. This study aimed to explain the foundational ideas of the Bayesian methods through an intuitive example in medical science and to illustrate some simple examples of Bayesian data analysis and the interpretation of results delivered by Bayesian analyses. In this study, data sparsity, as a problem which could be solved by this approach, was presented through an applied example. Moreover, a common sense description of Bayesian inference was offered and some illuminating examples were provided for medical investigators and nonexperts. Methods Data augmentation prior, MCMC, and Bayes factor were introduced. Data from the Khuzestan study, a 2-phase cohort study, were applied for illustration. Also, the effect of vitamin D intervention on pregnancy outcomes was studied.