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ures and patients that increase the risk of transmission of SARS-CoV-2.
Acutely decompensated of cirrhosis is a heterogeneous clinical entity associated with moderate mortality. In some patients, this condition develops quickly into a more often deadly acute-on-chronic liver failure (ACLF), in which other organs such as the kidneys or brain fail. The aim of this study was to characterize the blood lipidome in a large series of patients with cirrhosis and identify specific signatures associated with acute decompensation and ACLF development.
Serum untargeted lipidomics was performed in 561 patients with acutely decompensated (AD) cirrhosis (518 without and 43 with ACLF) (discovery cohort) and in 265 AD patients (128 without and 137 with ACLF) in whom serum samples were available to perform repeated measurements during the 28-day follow-up (validation cohort). Analyses were also performed in 78 AD patients included in a therapeutic albumin trial, 43 patients with compensated cirrhosis and 29 healthy subjects.
The circulating lipid landscape associated with cirrhosis was charahe circulation of these patients. A specific group of lipids known as sphingomyelins are useful to distinguish compensated from decompensated patients with cirrhosis. Another group of lipids designated cholesteryl esters further distinguish patients with decompensated patients who are at risk of developing organ failures.
Analysis of lipids in blood from patients with advanced cirrhosis reveals a general suppression of their levels in the circulation of these patients. A specific group of lipids known as sphingomyelins are useful to distinguish compensated from decompensated patients with cirrhosis. Another group of lipids designated cholesteryl esters further distinguish patients with decompensated patients who are at risk of developing organ failures.
Foods that increase obesity risk are ubiquitous in the US food environment. Such foods may be the target of hedonic eating, which may facilitate weight gain and lead to obesity. The study tested whether meal composition during an ad libitum buffet meal was associated with 1-year weight and percent body fat changes among healthy younger adults without obesity. Hyper-palatable foods (HPF) were the study focus; comparisons were conducted with high energy dense (HED) and ultra-processed foods (UPF).
Younger adults without obesity (N=82; 43% male; mean age 26.8) completed an ad libitum buffet meal and provided body composition measurements at baseline and 1-year follow up. Multiple regression models tested associations between the proportion of the target food consumed (HPF, HED, or UPF) during the ad libitum meal and 1) weight change and 2) percent body fat change. selleck chemical The proportion of HPF was characterized by HPF group, specifically carbohydrate and sodium (CSOD) foods or fat and sodium (FSOD) foods.
Participants who consumed a greater proportion of CSOD HPF in their ad libitum buffet meals had significantly greater weight change (b=0.354, p=.003) and percent body fat change (b=0.247, p=.036) at 1-year follow up. In contrast, no significant associations were found between the proportion of FSOD HPF, HED, or UPF consumed and anthropometric outcomes (p values=.099-.938).
Eating a greater proportion of hyper-palatable CSOD foods ad libitum appears to be a pattern of hedonic eating, which may increase an individual's risk for weight and body fat gain in early adulthood.
Eating a greater proportion of hyper-palatable CSOD foods ad libitum appears to be a pattern of hedonic eating, which may increase an individual's risk for weight and body fat gain in early adulthood.Research suggests that depictions of social groups can improve the processing of pronutritional media promoting healthy foods. Drawing on a framework of motivational processing, which regulates the automatic emotional and attentional responses to stimuli with adaptive significance to the organism (Cacioppo, Gardner, & Berntson, 1999; Compton, 2003; Ito, Cacioppo, & Lang, 1998), two mixed-factorial experiments examined how adolescents process pronutritional media depicting various social versus alone eating contexts. Based on motivational theories of information processing and emotional contagion, we predicted that pronutritional media depicting social eating contexts capture attention, emotion, and memory formation, indicative of appetitive motivational processing. Study 1 (N = 58; aged 12-18; 54% female) examined how the depicted social eating contexts improve the processing of pronutritional media by increasing their attentional selection, attentional processing, the emotional affect, and arousal responses appetitive motivational processing explicates their greater effectiveness.The insect taste system regulates insect feeding behavior and patterns of food consumption. In this study, we showed that the medial and lateral sensilla styloconica in the mouthparts of 5th-instar Asian corn borer larvae are sensitive to fructose and sucrose in a concentration-dependent way. The two sensilla produced significant electrophysiological responses (greater than100 spikes/s) by exposure to 10 mM fructose or sucrose. However, electrophysiological responses and feeding preferences to fructose or sucrose were inhibited by neuropeptide F double-stranded RNA (dsNPF). Additionally, the medial sensilla styloconica are sensitive to low concentrations of the deterrents caffeine and nicotine. However, starvation, followed by increases in larval npf expression plus feeding, led to increases in spike frequencies of related sensilla to fructose, sucrose, and deterrents. In contrast, these responses were reduced on the dsNPF treatment. Our results suggest that NPF plays an important role influencing caterpillar feeding behavior through regulating the taste neurons of the sensilla styloconica.
Micro-albuminuria is considered an early clinical sign of diabetes nephropathy, however, early decrease of glomerular filtration can be present years before the presence of microalbuminuria. In this study, we explored whether urinary epidermal growth factor (uEGF) might serve as an early marker of diabetes nephropathy compared to microalbuminuria in children and adolescents.
Children with type 1 diabetes mellitus (n = 158) and healthy controls (n = 40) were included in this study. Serum and urine samples were collected three times with an interval of at least one month to determine creatinine (serum and urine), epidermal growth factor and albumin (urine). Demographic data and routine lab values were extracted out of the electronic patient files.
uEGF was significantly lower in children with T1DM compared to healthy controls (p = 0.032). A relatively lower glomerular filtration rate (eGFR) was associated with a decreased uEGF (p < 0.001). uEGF was independently associated with eGFR in a multivariate analysis.