Pooleraun2590

The "surprisingly popular" method (SP) of aggregating individual judgments has shown promise in overcoming a weakness of other crowdsourcing methods-situations in which the majority is incorrect. This method relies on participants' estimates of other participants' judgments; when an option is chosen more often than the average metacognitive judgments of that option, it is "surprisingly popular" and is selected by the method. Although SP has been shown to improve group decision making about factual propositions (e.g., state capitals), its application to future outcomes has been limited. In three preregistered studies, we compared SP to other methods of aggregating individual predictions about future events. Study 1 examined predictions of football games, Study 2 examined predictions of the 2018 US midterm elections, and Study 3 examined predictions of basketball games. When applied to judgments made by objectively assessed experts, SP performed slightly better than other aggregation methods. Although there is still more to learn about the conditions under which SP is effective, it shows promise as a means of crowdsourcing predictions of future outcomes.To better understand the spread of fake news in the Internet age, it is important to uncover the variables that influence the perceived truth of information. Although previous research identified several reliable predictors of truth judgments-such as source credibility, repeated information exposure, and presentation format-little is known about their simultaneous effects. In a series of four experiments, we investigated how the abovementioned factors jointly affect the perceived truth of statements (Experiments 1 and 2) and simulated social media postings (Experiments 3 and 4). mTOR inhibitor Experiment 1 explored the role of source credibility (high vs. low vs. no source information) and presentation format (with vs. without a picture). In Experiments 2 and 3, we additionally manipulated repeated exposure (yes vs. no). Finally, Experiment 4 examined the role of source credibility (high vs. low) and type of repetition (congruent vs. incongruent vs. no repetition) in further detail. In sum, we found no effect of presentation format on truth judgments, but strong, additive effects of source credibility and repetition. Truth judgments were higher for information presented by credible sources than non-credible sources and information without sources. Moreover, congruent (i.e., verbatim) repetition increased perceived truth whereas semantically incongruent repetition decreased perceived truth, irrespectively of the source. Our findings show that people do not rely on a single judgment cue when evaluating a statement's truth but take source credibility and their meta-cognitive feelings into account.Genetic disorders such as Rubinstein-Taybi syndrome (RTS) and Coffin-Lowry syndrome (CLS) cause lifelong cognitive disability, including deficits in learning and memory. Can pharmacological therapies be suggested that improve learning and memory in these disorders? To address this question, we simulated drug effects within a computational model describing induction of late long-term potentiation (L-LTP). Biochemical pathways impaired in these and other disorders converge on a common target, histone acetylation by acetyltransferases such as CREB binding protein (CBP), which facilitates gene induction necessary for L-LTP. We focused on four drug classes tropomyosin receptor kinase B (TrkB) agonists, cAMP phosphodiesterase inhibitors, histone deacetylase inhibitors, and ampakines. Simulations suggested each drug type alone may rescue deficits in L-LTP. A potential disadvantage, however, was the necessity of simulating strong drug effects (high doses), which could produce adverse side effects. Thus, we investigated the effects of six drug pairs among the four classes described above. These combination treatments normalized impaired L-LTP with substantially smaller individual drug 'doses'. In addition three of these combinations, a TrkB agonist paired with an ampakine and a cAMP phosphodiesterase inhibitor paired with a TrkB agonist or an ampakine, exhibited strong synergism in L-LTP rescue. Therefore, we suggest these drug combinations are promising candidates for further empirical studies in animal models of genetic disorders that impair histone acetylation, L-LTP, and learning.

To describe a technique for flexion gap management in total knee arthroplasty (TKA) using conventional instrumentation with minimal soft tissue release, by aligning the femoral component to restore close-to-native posterior condylar angle (PCA). The hypothesis was that this technique renders consistent outcomes, regardless the preoperative deformity or intraoperative parameters.

In a consecutive series of 152 TKAs, the femoral component was rotated to restore anatomic PCA of 2° ± 2° and the flexion gap was balanced with a final lateral flexion laxity of 1-3mm. Patients were assessed using the Knee Society Score (KSS), the Oxford Knee Score (OKS) and University of California Los Angeles (UCLA) activity score at a minimum follow-up of 4years. Uni- and multivariable analyses were performed to determine associations between clinical scores and patient demographics, PCA, laxity, pre- and postoperative hip-knee-ankle (HKA) angle, and preoperative femoral mechanical angle (FMA) and tibial mechanical angle (TMA).faction were achieved, even in knees outside the target PCA range.

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IV.

The all-soft tissue quadriceps tendon (QT) autograft is becoming increasingly popular for ACL reconstruction (ACLR); however, studies reporting strength recovery and early outcomes after QT autograft are limited with patient samples composed of predominantly males. The primary purpose was to characterize early, sex-specific recovery of strength, range of motion (ROM), and knee laxity in a large cohort of patients undergoing primary ACLR with standardized harvest technique of the all-soft tissue QT autograft. The secondary purpose was to examine the influence of demographic factors and clinical measures on 6-month quadriceps strength.

Patients 14-25years who underwent primary, unilateral ACLR with all-soft tissue QT autografts were prospectively followed. Knee laxity and ROM were collected at 6weeks, 3 and 6months; while, quadriceps normalized torques and limb symmetry indices (LSI) were collected at 3 and 6months using isokinetic dynamometry at 60°/s. Two-way ANOVAs with repeated measures were conducted to determine recovery over time and between sexes.