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pening, decreased mATPase enhancement and mLPO, relative to the control. Histopathology of the liver showed extensive hemorrhagic lesions and severe disseminated congestion in the infected control while both D. iCRT14 in vitro mespiliformis and M. whitei were well tolerated at the highest dose. The LC-MS analysis of D. mespiliformis showed the presence of betulinic acid, tocopherol and kaempferol with antimalarial and antioxidant properties while the M. whitei sample contained coumarin and chlorogenic acid that have antimalarial and hepato-protective properties.

D.mespiliformis and M. whitei show antimalarial effects against resistant Plasmodium berghei infection, enhanced cell viability, mito-protection and are not toxic in mice.

D.mespiliformis and M. whitei show antimalarial effects against resistant Plasmodium berghei infection, enhanced cell viability, mito-protection and are not toxic in mice.

Seeds of Ipomoea hederacea Jacq. (family Convolvulaceae) are traditionally used to treat high blood pressure and cardiac diseases.

Present study was conducted to validate the traditional claim and explore the possible mechanism(s) of antihypertensive effects of I. hederacea.

Aqueous-ethanolic extract and activity based fractions of I. hederacea were evaluated using invasive blood pressure measuring technique, isolated tissue experiments, fructose induced hypertension/metabolic syndrome and biochemical analysis.Phytochemical analysis of active fraction was performed with aim to identify chemical composition of I. hederacea seeds. LC-MS analysis was also performed to identify the compounds proposed to be present in active fraction of I. hederacea seeds.

Crude extract/fractions of I. hederacea showed dose (0.01-100mg/kg) dependent significant hypotensive effect in normotensive anesthetized rats, similar to verapamil (0.01-30mg/kg). Pretreatment with hexamethonium and atropine mediated no significant chanh α1 blocking, β blocking and iNOS/cGMP stimulating activity.

Acceleration sensors are a viable option for monitoring gait patterns and its application on monitoring falls and risk of falling. However the literature still lacks prospective studies to investigate such risk before the occurrence of falls.

To investigate features extracted from accelerometer signals with the purpose of predicting future falls in individuals with no recent history of falls.

In this study we investigate the risk of fall in active and healthy community-dwelling living older persons with no recent history of falls, using a single accelerometer and variants of the Timed Up and Go (TUG) test. A prospective study was conducted with 74 healthy non-fallers older persons. After collecting acceleration data from the participants at the baseline, the occurrence of falls (outcome) was monitored quarterly during one year. A set of frequency features were extracted from the signal and their ability to predict falls was evaluated.

The best individual feature result shows an accuracy of 0.75, sensitivity of 0.71 and specificity of 0.76. A fusion of the three best features increases the sensitivity to 0.86. On the other hand, the cut-off points of the TUG seconds, often used to assess fall risk, did not demonstrate adequate sensitivity.

The results confirms previous evidence that accelerometer features can better estimate fall risk, and support potential applications that try to infer falls risk in less restricted scenarios, even in a sample stratified by age and gender composed of active and healthy community-dwelling living older persons.

The results confirms previous evidence that accelerometer features can better estimate fall risk, and support potential applications that try to infer falls risk in less restricted scenarios, even in a sample stratified by age and gender composed of active and healthy community-dwelling living older persons.

To determine whether fatigue may be a risk factor for falling in older men and women, independent of other components of the frailty phenotype, fear of falling, and physical performance.

Among 986 women and 485 men visiting a health resort (mean age 72.3 and 72.7, respectively), subjects with at least one fall in the previous year were compared with non-fallers using a multivariate logistic regression analysis. Age, fatigue and fear of falling over the previous month were assessed by visual analogue scale (VAS), and the past 7days of activity were assessed using the International Physical Activity Questionnaire. The following parameters were also assessed weight loss in the past year, maximum grip strength measured with a hand dynamometer, time to perform the 5-chair stand and the up and go tests, time to walk 4m, time held on one leg, feet together, as well as in the semi-tandem and tandem positions.

A feeling of fatigue (VAS score≥5/10 in women or ≥4/10 in men), a fear of falling (VAS score≥4/10 in women or ≥2 in men), and poor balance (time held in semi-tandem position < 10s in women and time held on one leg < 6.5s in men) were the 3 independent parameters distinguishing fallers from non-fallers.

The present study suggests the interest of adding a VAS score of fatigue to that of fear of falling and balance measurements for screening men and women aged 65 or older who are at risk of falls.

The present study suggests the interest of adding a VAS score of fatigue to that of fear of falling and balance measurements for screening men and women aged 65 or older who are at risk of falls.

Emerging evidence has suggested that physical activities can reduce the risk of benign prostatic hyperplasia (BPH). Here, we evaluated the effect of aerobic exercise in a model of BPH using obese mice.

Obese C57BL/6J mice in the control group, obesity group (OB), and obesity group plus exercise (OB+E) with eight weeks training were inspected for morphological alterations via hematoxylin-eosin (H&E) staining, lipid and sex hormone metabolites via enzyme-linked immunosorbent assays (ELISAs), relative protein expression via Western blotting, and prostate cancer-up-regulated long noncoding RNA (PlncRNA) and androgen receptor (AR) mRNA levels via quantitative real-time PCR (qRT-PCR).

Aerobic exercise training slowed fat-mass gain in OB mice. Prostate volume (PV) and area of lumen was significantly decreased in OB mice and was slightly increased following aerobic exercise. Epithelial volume density in the OB group was higher than that in the control group. Furthermore, aerobic exercise lowered serum low-density lipoprotein (LDL), triglyceride, and free fatty acid (FFA) levels, whereas it raised high-density lipoprotein (HDL) levels in OB+E mice.