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In this 5-year cohort study, we aimed to determine whether the intake of natto, a fermented soya bean food product, has an indirect effect on tooth loss incidence through BMD changes among postmenopausal women.

Evidence indicates (1) that natto has a beneficial effect on bone health and (2) that a decrease in bone mineral density (BMD) is associated with tooth loss.

The study recruited 435 postmenopausal women (average age=64.2years). Natto intake (exposure) was assessed at baseline using a food frequency questionnaire. Lumbar spine BMD and number of teeth were measured at baseline and 5-year follow-up. BMD change (mediator) and the number of teeth lost (outcome) over time were calculated. The mediation model consisted of these 3 variables. Mediation analysis was performed to test the indirect effect of the natto intake measured through BMD change on tooth loss.

During the study, the mean number of teeth lost was 1.2 (standard deviation=1.8), and the mean BMD decline was 2.5% (standard deviation=7.1). After adjusting for potential confounders, increasing habitual natto intake was significantly indirectly associated with a lower incidence of tooth loss mediated by BMD change (incidence rate ratio of tooth loss among women with "≥1 pack/day" natto intake was 0.90 [95% confidence interval=0.82-0.99] compared to those with natto consumption of "rarely").

Dietary natto intake is significantly indirectly associated with a lower incidence of tooth loss among postmenopausal women, and systemic bone density could be a mediator of this association.

Dietary natto intake is significantly indirectly associated with a lower incidence of tooth loss among postmenopausal women, and systemic bone density could be a mediator of this association.

Ifosfamide, an alkylating agent, is widely used in the treatment of malignant diseases. However, these treatments are often limited due to the incidence of neuropsychiatric symptoms such as delirium, seizures, hallucinations and agitation. In this study, we examined risk factors for neuropsychiatric symptoms in patients receiving ifosfamide-based chemotherapy.

The study cases were patients with cancer receiving ifosfamide-based chemotherapy between April 2007 and March 2018. Risk analysis for ifosfamide-related neuropsychiatric symptoms was determined by time-dependent Cox proportional hazard regression analysis.

Of 183 eligible patients, 32 patients (17.5%) experienced ifosfamide-related neuropsychiatric symptoms. Time-dependent Cox proportional hazard model showed that the albumin-bilirubin (ALBI) score was significantly correlated with the incidence of ifosfamide-related neuropsychiatric symptoms (hazard ratio [HR]=1.45, 95% confidence interval [CI]=1.05-2.01, p=0.025). Additionally, there were correlations between the predicted risk of neuropsychiatric symptoms and ifosfamide-dose per cycle (HR =0.51, 95% CI=0.27-0.94, p=0.030) and creatinine clearance (Ccr) (HR=0.53, 95% CI=0.28-1.00, p=0.050). In contrast, neither serum albumin nor total bilirubin was a significant risk factor for neuropsychiatric symptoms.

These findings indicate that ALBI score may be a useful biomarker for predicting neuropsychiatric symptoms in patients receiving ifosfamide-based chemotherapy.

These findings indicate that ALBI score may be a useful biomarker for predicting neuropsychiatric symptoms in patients receiving ifosfamide-based chemotherapy.

Vasculopathy is considered central to the pathogenesis of Juvenile dermatomyositis (JDM) and is associated with severe extra-muscular manifestations. We hypothesised that we can non-invasively track the vasculopathy of JDM by examining biomarkers of endothelial injury, subclinical inflammation, hypercoagulability, and vascular arterial stiffness in a UK cohort of children with JDM.

Circulating endothelial cells (CEC) and microparticles (MP) were identified using immunomagnetic bead extraction, and flow cytometry, respectively. Plasma thrombin generation was determined using a fluorogenic assay. Cytokines/chemokines were measured by electrochemiluminescence. Arterial stiffness was assessed using pulse wave velocity (PWV). Results were expressed as median (interquartile range), and compared with non-parametric analyses (significance at P<0.05).

Ninety JDM patients were included; age 10.21 (6.68-13.40) years; disease duration 1.63 (0.28-4.66) years. CEC were higher in all JDM patients at 96 (40-192) cel pathology, platelet activation and thrombotic propensity. Ongoing long-term vascular injury may result in increased arterial stiffness in JDM.The FEBS Journal, a leading multidisciplinary journal in the life sciences, continues to grow in visibility and impact. Here, the Editor-in-Chief Seamus Martin discusses developments at the journal over the past year and the impact of the COVID-19 crisis on research activities.There is growing interest in developing intracellular RNA tools. Herein, we describe a strategy for N3 -kethoxal (N3 K)-based bioorthogonal intracellular RNA functionalization. With N3 K labeling followed by an in vivo click reaction with DBCO derivatives, RNA can be modified with fluorescent or phenol groups. This strategy provides a new way of labeling RNA inside cells.This work investigated the outcomes of dietary administration of Echinacea purpurea (EP) powder to breeder ducks on productive and reproductive performance during summer season. Sudani ducks (320 birds) of 32-weeks-old (240 females and 80 males) were randomly allocated into four collections (body weight; 1850 ± 15.2 g for females and 2960.0 ± 40.5 g for males). The primary collection consumed the basal diet without supplementation and was deliberated as control. Epigenetic inhibitor concentration The other three collections were fed the basal diet supplemented with 2.5, 5.00 and 7.5 g EP/kg diet, correspondingly. Egg number and mass, laying rate, feed consumption and feed conversion ratio (FCR) were significantly changed by dietary EP levels. Drakes fed EP-supplemented diets had higher ejaculate volume, sperms concentration and live sperms (%) as well as lower dead sperms (%) than the control group. Eggs laid by ducks fed diet supplemented with 2.5 g/kg had the greatest fertility and hatchability percentages, followed by those fed 5.0 g EP/kg.