Aarupmurdock7229
The facile and practical design of this multichannel Ca2+ nanomodulator will contribute to the development of multimodal bioimaging-guided organelle-targeted cancer therapy in the future.A recent report from the European Sleep Research Society's task force "Beyond AHI" discussed an issue that has been a long-term subject of debate - what are the best metrics for obstructive sleep apnoea (OSA) diagnosis and treatment outcome assessments? In a similar way, sleep bruxism (SB) metrics have also been a recurrent issue for >30 years and there is still uncertainty in dentistry regarding their optimisation and clinical relevance. SB can occur alone or with comorbidities such as OSA, gastroesophageal reflux disorder, insomnia, headache, orofacial pain, periodic limb movement, rapid eye movement behaviour disorder, and sleep epilepsy. Classically, the diagnosis of SB is based on the patient's dental and medical history and clinical manifestations; electromyography is used in research and for complex cases. The emergence of new technologies, such as sensors and artificial intelligence, has opened new opportunities. The main objective of the present review is to stimulate the creation of a collaborative taskforce on SB metrics. Several examples are available in sleep medicine. The development of more homogenised metrics could improve the accuracy and refinement of SB assessment, while moving forward toward a personalised approach. It is time to develop SB metrics that are relevant to clinical outcomes and benefit patients who suffer from one or more possible negative consequences of SB.
Dobutamine-atropine stress echocardiography (DSE) has lower sensitivity in patients with advanced liver disease (ALD) due to vasodilation.
Dopamine-atropine stress echocardiography (DopSE) may be an alternative to DSE in ALD patients by improving the blood pressure response to stress.
The safety and tolerability of DSE and DopSE were compared in 10 volunteers. The safety, adverse effects, and efficacy of DopSE were then assessed in 105 patients, 98 of whom had ALD. Dopamine was infused in stepwise fashion from 5µg/kg/min to a peak dose of 40µg/kg/min. Atropine was given before and in early stages of dopamine infusion up to cumulative dose of 1.5mg. The hemodynamic responses of 98 ALD patients were compared with 102 patients with ALD who underwent standard DSE.
In normal volunteers, systolic BP increased more with DopSE compared to DSE (61±19mmHg vs 39±15mmHg, P=.008). In 105 patients who underwent DopSE, none had adverse effects that required early stress termination. In the groups with ALD, the systolic BP increase (38±28mmHg vs 12±27mmHg, P<.001) and peak rate pressure product (RPP) (22861±5289 vs 17211±3848, P=<.001) were both higher in those undergoing DopSE versus DSE. The sensitivity and specificity of DopSE were 45% and 88%, respectively for coronary disease (≥70% stenosis) in 37 patients who had angiography.
Dopamine-atropine stress echocardiography appears to be a safe stress modality and provides greater increases in RPP in patients with ALD compared to DSE.
Dopamine-atropine stress echocardiography appears to be a safe stress modality and provides greater increases in RPP in patients with ALD compared to DSE.This study examines the impact of peers' previous cautious versus risky choices on adolescents' risk-taking depending on the level of information about the risk. Adolescents completed an adaptation of the BART that manipulated social influence (cautious and risky) and risk information (i.e., informed, noninformed). Results showed that social influence impacts adolescents' decisions on the noninformed BART but not on the informed BART. In the noninformed BART, the peers' cautious choices strongly decreased risk-taking and led to greater performance. see more The peers' risky choices increase adolescents' risk-taking, but this effect is limited to situations involving minimal risk. Thus social experience may be a specific social context that represents a valuable source of information during adolescence, especially in situations with high uncertainty.
Feed additives that accelerate gastrointestinal transit time may help support normal gastrointestinal function in horses at risk for impaction colic. Previous research has demonstrated significant stimulatory effect of a hemp-based nutraceutical product (Gs Formula; GF) on contractility of gastric smooth muscle and gastrin production in vitro.
To quantify effects of GF on indicators of GIT transit time and tight junction proteins.
Randomized placebo-controlled cross-over study.
Eight Standardbreds were administered 200 plastic beads by nasogastric tube before (baseline; BL) and after receiving a diet containing GF (CON 0g/day, LO 160g/day or HI 480g/day) for 28days. Total manure collection occurred every 2hours for 72hours after bead administration. Outcome measures included GIT transit time, faecal dry matter (DM), water intake, and complete biochemistry and haematology screens.
There was no effect of GF on GIT transit time. Faecal output was significantly lower in LO and HI horses than CON horses after 28days on the supplement. HI horses have significantly lower rouleaux formation and lower faecal DM on Day 28 compared with BL. GF also produced changes in electrolytes associated with pH balance, which may indicate a role for GF as an alkalinizing compound in exercising horses. Clinical pathology results support the safety of GF up to 480g/day for 28days with no adverse effects being observed in haematology or biochemistry results.
Future studies on GF should focus on evaluating effect of GF on gastrointestinal transit in horses with naturally or experimentally delayed gastrointestinal motility, and its effect on exercise performance and onset of fatigue.
GF may help support normal gastrointestinal function in horses at risk for impaction colic by reducing faecal DM and rouleaux formation.
GF may help support normal gastrointestinal function in horses at risk for impaction colic by reducing faecal DM and rouleaux formation.
The COVID-19 pandemic led to limit patients' visits to the neuro-urology department. Telemedicine was seen as a pragmatic solution to provide follow-up care. This study aimed to assess the efficiency and satisfaction of a telephone consultation in neuro-urology.
During the pandemic, the scheduled medical visits were converted into telephone consultation. For each teleconsultation, the physician assessed the efficiency and the patient-rated global satisfaction of the teleconsultation. The physician and the patient assessed whether this teleconsultation replaced a physical visit.
About 358 neurologic patients were included in the study. The mean efficiency of the telephone consultation was 9.3/10 (±1.5). The mean global satisfaction was 9.0/10 (±1.3). The majority of the patients (52.4%) would prefer a physical consultation. 90.2% might convert some clinic visits to teleconsultations in the future. No agreement was found between the patient and the physician when they were asked if the teleconsultation replaced the physical consultation initially scheduled (weight kappa = 0.
