Adlervalentin7688

Research is needed to better understand how childhood maltreatment history affects parental reflective capacities, and whether early childhood interventions help mitigate these effects. We examined associations between childhood maltreatment and current parenting (parental reflective functioning, parenting behaviors) among mothers who participated in a follow-up study (N = 97) of the Minding the Baby® (MTB) randomized control trial. MTB is a home visiting program that aims to help mothers understand their child's mental states (feelings, intentions, needs) by promoting parental reflective functioning. Mothers retrospectively reported childhood maltreatment using the Childhood Trauma Questionnaire. Endorsing a higher number of childhood maltreatment subtypes was associated with less supportive/engaged parenting and higher pre-mentalizing modes, or difficulty with appropriately reflecting on the child's mental states. These relationships were not moderated by participation in the MTB intervention. However, exploratory analyses of individual maltreatment subtypes revealed that participation in MTB may mitigate the harmful effects of childhood emotional abuse on pre-mentalizing modes, specifically. Further research is needed to understand the mechanisms through which early childhood interventions may prevent intergenerational cycles of maltreatment.Platelets mediate circulating endothelial progenitor cell (EPC) recruitment and maturation, participating in vascular repair, however the underlying mechanism(s) remain unclear. We investigated the effect of platelet-rich plasma (PRP) on the functionality of CD34+-derived late-outgrowth endothelial cells (OECs) in culture. Confluent OECs were coincubated with PRP under platelet aggregation (with adenosine diphosphate; ADP) and nonaggregation conditions, in the presence/absence of the reversible P2Y12 platelet receptor antagonist ticagrelor. Outgrowth endothelial cell activation was evaluated by determining prostacyclin (PGI2) and monocyte chemoattractant protein-1 (MCP-1) release and intercellular adhesion molecule-1 (ICAM-1) membrane expression. Similar experiments were performed using human umbilical vein endothelial cells (HUVECs). Platelet-rich plasma increased ICAM-1 expression and PGI2 and MCP-1 secretion compared with autologous platelet-poor plasma, whereas ADP-aggregated platelets in PRP did not exhibit any effect. Platelet-rich plasma pretreated with ticagrelor prior to activation with ADP increased all markers to a similar extent as PRP. Similar results were obtained using HUVECs. In conclusion, PRP induces OEC activation, a phenomenon not observed when platelets are aggregated with ADP. Platelet inhibition with ticagrelor restores the PRP capability to activate OECs. Since EPC activation is important for endothelial regeneration and angiogenesis, we suggest that agents inhibiting platelet aggregation, such as ticagrelor, may promote platelet-EPC interaction and EPC function.The present work experimentally examines how identity cues that signal minority inclusion contribute to sexual minorities' (SM) healthcare visit expectations. Belnacasan We find that minority representation cues reduced SM's (N = 188) expectations of a healthcare provider's bias and increased perceived provider cultural competency which was, in turn, associated with lower anticipated identity-based devaluation and greater sexual orientation disclosure comfort. Providers' diversity-valuing statements had mixed effects highlighting the importance of more concrete indicators of inclusion in this context. This work suggests that a lack of identity safety cues in healthcare settings may contribute to disparate health outcomes for sexual minority populations.The current study examined the prevalence and mental health associated with physical and sexual dating violence among adolescents using an intersectional analysis. Data were obtained from 88,219 adolescents in the Youth Risk Behavior Surveillance Survey. Gender, race/ethnicity, sexual orientation, and experiences with teen dating violence were measured for each youth. Tested two- and three-way interactions demonstrate varied outcomes by social identification and emphasize the need for an intersectional approach in dating violence research. Adolescent dating violence was most prevalent among girls (10% physical, 13% sexual); adolescents were racially identified as Native North American (13% physical, 10% sexual), Hawaiian/Pacific Islander (12% physical, 14% sexual), or multiracial (11% physical, 12% sexual), and lesbian, gay, bisexual, or questioning their sexual orientation (LGBQ) adolescents (19% physical, 20% sexual). The intersectional groups with the highest rates of physical and sexual dating violence included Latinx GBQ boys (26% physical, 26% sexual) and Hawaiian/Pacific Islander GBQ boys (29% physical, 32% sexual). Among girls, highest rates were observed among Hawaiian/Pacific Islander LBQ (24% physical, 23% sexual). Externalizing symptoms associated with physical dating violence were most robust for risky sexual behavior (OR = 4.0), followed by physical fighting (OR = 3.0), and weapon carrying (OR = 2.5); they were also associated with sexual dating violence (ORs = 1.9-2.2). Internalizing symptoms were comparably associated with both types of dating violence (ORs = 2.6-2.9 physical and ORs = 2.4-2.8 sexual). Findings suggest first that an intersectional approach is especially informative in teen dating violence prevention and intervention and second that teen dating violence interventions and prevention programming should use a trauma-informed, gender-responsive, culturally sensitive, and LGBQ inclusive approach.Atherosclerosis plays an important role in saphenous vein graft disease (SVGD). Previous studies showed that inflammatory blood cells play an active role in this process. C-reactive protein to albumin ratio (CAR) is considered as a novel predictor for cardiovascular risk and an indicator of inflammation. We aimed to assess the relationship between SVGD and CAR. A total of 711 participants with saphenous vein graft (SVG) were included; 348 patients had SVGD and 363 patients had patent (no stenosis) SVG. C-reactive protein to albumin ratio was higher in patients with SVGD (P less then .001). There was a significant positive correlation between CAR and the age of SVG (r = 0.123; P = .001) and SYNTAX score (r = 0.568; P less then .001). Multivariate logistic regression analyses showed that lymphocyte count, CAR, and SYNTAX score were independent predictors of SVGD (P less then .05). C-reactive protein to albumin ratio may be a useful marker after bypass surgery to predict SVGD.