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566, P = 0.022). Radioactive distribution in aggressive hemangiomas was homogeneous and heterogeneous in nine and eight cases, respectively. In six aggressive hemangiomas, the FDG uptake of residual and marginal sclerosing bone was higher than that of the osteolytic destruction area and/or paravertebral soft tissue. Six aggressive hemangiomas involved the spinal canal, without clear visualization on PET/CT. CONCLUSION 18F-FDG uptake of vertebral malignant vascular tumors is higher than that of hemangiomas. The FDG uptake of hemangiomas varies and may be related to concurrent cortical destruction. 18F-FDG PET/CT shows limitations in evaluating the spinal canal involvement of aggressive hemangioma. PURPOSE Interventions to decrease anxiety associated with image-guided breast biopsy are needed. Music intervention has been shown to be helpful in other outpatient procedural settings but data are limited regarding its effectiveness in the setting of breast biopsy. The purpose of this study was to determine whether listening to self-selected music during image-guided breast biopsy lowers anxiety. MATERIALS AND METHODS This randomized controlled trial was approved by the institutional review board and was HIPAA-compliant. 157 women between 18 and 75 (mean, 49.7 years) years of age, undergoing stereotactic or ultrasound-guided core biopsy, were enrolled in the study and were prospectively randomized to music or usual care. Patients in the music group listened to music of their choice during the biopsy. All patients completed the State Trait Anxiety Inventory (STAI) before and after the biopsy. Differences in pre-biopsy and post-biopsy anxiety levels were compared between the two groups using the Mann-Whitney U test. RESULTS Baseline trait anxiety scores in the two groups were similar (34.0 music, 31.5 control, p = .11). Patients in both groups showed lower state anxiety levels after the biopsy (45.6 to 34.3 music, 41.0 to 33.8 control, p  less then  .001 for both). Patients who listened to music showed a greater reduction in anxiety (mean decrease 11.2 music, 7.3 control, p = .03). Post-biopsy anxiety levels were similar to normative values for working women in the same age group. CONCLUSION Listening to self-selected music reduces anxiety in patients undergoing breast biopsy. Published by Elsevier Inc.Crizotinib is a tyrosine kinase inhibitor that has been found to be effective in the treatment of anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer. This targeted cancer therapy agent has been shown to have superior efficacy over standard chemotherapy in this small subset of lung cancer patients. An adverse effect of this drug therapy is the development of complex renal cysts. Here, we present a case of a 68-year-old patient with non-small cell lung cancer on Crizotinib therapy who developed complex bilateral renal cysts. It is important to recognize this drug-related complication in order to avoid mistaking it for disease progression, primary renal malignancy, or renal infection. Survival data from 225 patients with resected pulmonary typical carcinoids were analyzed with Kaplan-Meier statistics (K-M) and "deep learning" methods to illustrate the difference between establishing "correlations" and "prognostications". Cases were stratified into G1 and G2 classes using a ≤5% Ki-67% cut-point. Overall survival, number of patients at risk and 95% confidence intervals (CI) were estimated for the two classes. Seven neural network models (NN) were developed with GMDH Shell 3.8.2 and Statgraphics Centurion 18.1 software, using variable prior probabilities and different numbers of training vs testing cases. The NNs used age, sex, and pTNM, G1 and G2 as input neurons and "alive" and "dead" as output neurons. Areas under the curve (AUC) and other performance measures were evaluated for all models. Log-rank test showed a significant difference in overall survival between G1 and G2 (p  less then  0.001). However, 95% CI estimates showed considerable variability in survival at different time intervals. Including the number of patients at risk at different time intervals showed that most G2 patients had been censored by 100 weeks. The NN models provided variable "prognostications", with AUC ranging from 0.5 to 1 and variability in the sensitivity, specificity, and other performance measures. The results illustrate the limitations of survival statistics and NNs in predicting the prognosis of individual patients. The need for pathologists not to overinterpret the finding of significant correlations as "prognostic" or "predictive" for individual patients is discussed. Solubilization of n-alkanes by dirhamnolipid (diRL) biosurfactant at sub-critical micelle concentrations (sub-CMC) was studied and the results were compared to that for monorhamnolipid (monoRL) obtained in our prior study. The results show that the apparent solubility of the four alkanes (decane, dodecane, tetradecane and hexadecane) increases linearly with the increase of diRL concentration at diRL concentrations below CMC. Selleck RRx-001 The solubilization potential of diRL indicated by molar solubilization ratio (MSR) is higher at sub-CMC than at hyper-CMC concentrations (0.43 vs 0.03, 7.91 vs 0.02, 5.16 vs 1.98 and 3.71 vs 1.26 for decane, dodecane, tetradecane and hexadecane, respectively). The maximum access at the surface of the alkane-rhamnolipid aggregates (Гmax) is smaller for diRL than for monoRL (2.47 vs 3.09, 2.35 vs 2.86, 2.26 vs 3.60, and 2.01 vs 4.09 mol/m2 for decane, dodecane, tetradecane and hexadecane, respectively). In addition, more significant impact of surface access change on the size of the aggregates were observed for diRL, indicating that the difference in the structure of polar group between diRL and monoRL (one more rhamnose ring in diRL polar group) has influence on alkane-solubilization behavior. Due to the smaller access at the surface of the aggregates, diRL can produce larger number of aggregates than monoRL in the solution and thus show higher solubilization efficiency of dodecane, tetradecane and hexadecane. The findings of the study add to the knowledge of solubilization of hydrophobic organic compounds by surfactants and contribute to application of rhamnolipid biosurfactant in the area of remediation.