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Q. Su and X. Xu, J. Chem. Theory Comput. 2015, 11, 4,677] is revealed. When these MP2-based methods are applied to a set of atoms and molecules, new insights are gained on the role played by the relaxation and the correlation effects in the electron ionization processes. © 2020 Wiley Periodicals, Inc.OBJECTIVES Preadolescent social media use is normative and could influence mental health. This study investigated (a) Differences between preadolescent users and non-users of various social media platforms on mental health, (b) unique links between time spent on those platforms, appearance-based activities on social media, and mental health, and (c) the moderating role of biological sex on those relationships. METHOD Preadolescent youth (N = 528; 50.9% male) completed online surveys. RESULTS Users of YouTube, Instagram, and Snapchat reported more body image concerns and eating pathology than non-users, but did not differ on depressive symptoms or social anxiety. Appearance investment uniquely predicted depressive symptoms. Appearance comparisons uniquely predicted all aspects of mental health, with some associations stronger for females than males. CONCLUSIONS Preadolescents could be encouraged to reduce their opportunities to make appearance comparisons and to invest less in their appearance on social media. Preadolescents may benefit from social media intervention programs. © 2020 Wiley Periodicals, Inc.Drug-induced liver injury (DILI) is a common side effect of chemotherapy resulting in jaundice, transaminitis, increases in alkaline phosphatase, and/or gamma glutamyl transferase. We report a presentation of recurrent, isolated indirect hyperbilirubinemia secondary to cytarabine-based chemotherapy. © 2020 by the American Association for the Study of Liver Diseases.BACKGROUND The effect of novel tobacco products, such as electronic cigarettes (EC) and heated tobacco products (HTP), on allergic rhinitis (AR) and asthma is not well known. OBJECTIVE To evaluate the health effect of novel tobacco products on asthma and AR. METHODS This study was conducted using large survey data on Korean middle and high school students. The relationship between current asthma/AR and novel tobacco products user status was evaluated. In order to compare the combined effects of conventional cigarette (CC), EC, and HTP use on current allergic diseases, the participants were classified into 18 groups based on CC (current, former, and never), EC (current, former, and never), and HTP (ever and never) status. RESULTS A total of 60,040 participants representing 2,850,118 Korean adolescents were analyzed. Of all participants, 6.7%, 2.7%, and 2.9% were current CC, current EC, and ever HTP users, respectively. Current CC and ever HTP use was significantly associated with current asthma and AR in adjusted models. Current EC showed association with current AR but the association with asthma disappeared in the adjusted model. Among 18 groups, the groups including current CC use showed higher risk of current AR and asthma than never HTP-never EC-never CC group. The odds ratio of current asthma especially increased more in those who used EC and/or HTP with CC concurrently than those in the never HTP-never EC-current CC user group. CONCLUSION Using EC and/or HTP in adolescents might enhance the adverse effect of CC on AR and asthma. © 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.RATIONALE We report the unsolved molecular structure of the complex biopolymer sporopollenin exine extracted from Lycopodium clavatum pollen grains. METHODS TOF-SIMS and CID-MS/MS, MALDI-TOF-MS and CID-TOF/TOF-MS/MS were used for the analysis of this complex biopolymer sporopollenin exine extracted from Lycopodium clavatum pollen grains. Solid-state 1 H- and 13 C-NMR, 2D 1 H-1 H NOESY, Rotor-synchronized 13 C1 H HSQC, and 13 C1 H multi CP-MAS NMR experiments were used to confirm the structural assigments revealed by MS and MS/MS studies. Finally, high-resolution XPS was used to check for the presence of aromatic components in sporopollenin. RESULTS The combined MS and NMR analyses showed that sporopollenin contained poly(hydroxy acid) dendrimer-like networks with glycerol as a core unit, which accounted for the sporopollenin empirical formula. In addition, these analyses showed that the hydroxy acid monomers forming this network contained a β-diketone moiety. Moreover, MALDI-TOF-MS and MS/MS allowed us to identify a unique macrocyclic oligomeric unit composed of polyhydroxylated tetraketide-like monomers. Lastly, high-resolution X-ray photoelectron spectroscopy (HR-XPS) showed the absence of aromaticity in sporopollenin. CONCLUSIONS We report for the first time the two main building units that form the Lycopodium clavatum sporopollenin exine. The first building unit is a macrocyclic oligomer and/or polymer composed of polyhydroxylated tetraketide-like monomeric units, which represents the main rigid backbone of the sporopollenin biopolymer. The second building unit is the poly(hydroxy acid) network in which the hydroxyl end groups can be covalently attached by ether links to the hydroxylated macrocyclic backbone to form the sporopollenin biopolymer, a spherical dendrimer. Such spherical dendrimers are a typical type of microcapsule that have been used for drug delivery applications. Finally, HR-XPS indicated the total absence of aromaticity in the sporopollenin exine. © 2020 John Wiley & Sons, Ltd.KEY POINTS Muscular dystrophy patients suffer from progressive degeneration of skeletal muscle fibres, sudden spontaneous falls, balance problems, as well as gait and posture abnormalities. Dystrophin- and dysferlin-deficient mice, models for different types of muscular dystrophy with different aetiology and molecular basis, were characterized to investigate if muscle spindle structure and function are impaired. The number and morphology of muscle spindles were unaltered in both dystrophic mouse lines but muscle spindle resting discharge and their responses to stretch were altered. In dystrophin-deficient muscle spindles, the expression of the paralogue utrophin was substantially upregulated, potentially compensating for the dystrophin deficiency. The results suggest that muscle spindles might contribute to the motor problems observed in patients with muscular dystrophy. selleck products ABSTRACT Muscular dystrophies comprise a heterogeneous group of hereditary diseases characterized by progressive degeneration of extrafusal muscle fibres as well as unstable gait and frequent falls.