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To elucidate the value of serum lncRNA SNHG5 as a marker for the diagnosis and prognosis in gastric cancer.

From January 2017 to January 2018, serum samples were collected from 50 cases of gastric cancer patients and 50 cases of benign gastrosia who underwent operations in our hospital, and 50 cases of healthy person. We detected the expression level of serum lncRNA SNHG5 in all research targets and the expression levels of LncRNA SNHG5 in the cancer adjacent tissues and cancer tissues of gastric cancer patients to analyze the relationship between serum LncRNA SNHG5 level and clinicopathological parameters. ROC curve was used to analyze its prognostic value of patients with gastric cancer, while Cox regression model was used to analyze the survival predictors of short-term adverse events.

The expression of lncRNA SNHG5 in the serum of gastric cancer was down-regulated, lower than that in the benign gastrosia group and healthy group (

< 0.05). The relative expression of lncRNA SNHG5 in cancer tissuenosis of gastric cancer.

To determine the positive effect of levonorgestrel-releasing intrauterine system (LNG-IUS) combined with progesterone on endometrial thickness and pregnancy outcomes of patients with atypical endometrial hyperplasia (AEH) or early-stage endometrial cancer (EEC).

Patients with AEH or EEC admitted to our hospital were enrolled, and assigned to a control group (con group) and a combination group (com group). Cyclopamine Patients in the con group were treated with LNG-IUS, while those in the com group were treated with LNG-IUS combined with progesterone. After treatment, the two groups were compared in efficacy, menstrual blood volume (pictorial blood loss assessment chart (PBAC) score), and changes in endometrial thickness. In addition, the incidence of adverse drug reactions and pregnancy outcomes of the patients were analyzed.

Before treatment, there was no significant difference in PBAC score and endometrial thickness between patients with AEH or EEC in the con group and those in the com group, but after 3 months and 6 months of treatment, the com group got a better PBAC score and better changes of endometrial thickness than the con group, and the incidence of adverse drug reactions in the com group was also significantly lower than that in the con group. In addition, the follow-up results of pregnancy outcomes of patients showed that the fertility rate and total effective rate of the com group were both significantly higher than those of the con group (both

<0.05).

LNG-IUS combined with progesterone is more effective in treating patients with AEH or EEC. It can effectively improve the endometrial thickness of patients and fertility rate of those with fertility requirements after treatment.

LNG-IUS combined with progesterone is more effective in treating patients with AEH or EEC. It can effectively improve the endometrial thickness of patients and fertility rate of those with fertility requirements after treatment.

To study the effect of propofol combined with remifentanil on hemodynamics and anesthetic effect in patients undergoing laparoscopic ovarian cystectomy under laryngeal mask airway (LMA) anesthesia.

From December 2018 to December 2019, gynecological patients who underwent laparoscopic ovarian cystectomy in our hospital were chosen and randomly separated into control group (group A) and combination group (group B). In the group B, patients were anesthetized with remifentanil combined with propofol. In the group A, patients were anesthetized with fentanyl combined with propofol. The anesthetic effect, hemodynamic changes, alertness-sedation score (OAAS), verbal depiction score (VRA), postoperative VAS score and adverse reactions were observed and compared in both groups.

The anesthesia induction time, recovery time of postoperative spontaneous respiration, time of opening eyes and time of removing laryngeal mask in the group B were shorter than those in the group A, and the difference was statistically significant (P<0.05). The OAAS scores at the time of recovery and 5 min after laryngeal mask removal in the group B were obviously lower than those in the group A. The mean arterial pressure and heart rate before and after 40 min pneumoperitoneum were more stable than those in the group A. The degree of postoperative pain in the group B was also significantly weaker than that in the group A. The incidence of postoperative adverse reactions was also lower than that of the group A, and the difference was statistically significant (P<0.05).

Propofol combined with remifentanil and LMA anesthesia has better anesthetic effect, more stable condition and higher safety for patients undergoing laparoscopic ovarian cystectomy.

Propofol combined with remifentanil and LMA anesthesia has better anesthetic effect, more stable condition and higher safety for patients undergoing laparoscopic ovarian cystectomy.Objective The aim of this study was to investigate the heart rate variability (HRV) in patients with Type 2 diabetes mellitus (T2DM) who underwent spinal anesthesia using dexmedetomidine for lower limb surgery.

T2DM patients were divided into two groups, namely the controlled group (HbA1c < 7%) and the uncontrolled group (HbA1c > 7%) according to the glycosylated hemoglobin (HbA1c) level, and patients with non-T2DM as the normal group, 30 cases in each group. The HRV, including low-frequency (LF) power, high-frequency (HF) power, total power (TP) and LF/HF ratio, was measured 10 min before spinal anesthesia (T0) and 10 min (T1), 20 min (T2) and 30 min (T3) after spinal anesthesia with dexmedetomidine.

We observed that TP, LF, and HF power in the uncontrolled group were remarkably lower than that in the other two groups at T0 (P < 0.05). In the controlled group, the LF power dropped markedly at T1-2 than the normal group. The LF power in the uncontrolled group did not show significant change at allso. For such patients, spinal anesthesia can result in a markedly increase in SBP and DBP.

Spinal anesthesia with dexmedetomidine affects autonomic nerve function in patients whose glycemic control is better during the lower limb surgery in T2DM patients, but has no significant effect on patients who fail to do so. For such patients, spinal anesthesia can result in a markedly increase in SBP and DBP.