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Because of the low observed allele frequencies, positivity on the MEFV gene mutation test may have no diagnostic value in a population with low FMF prevalence.

Prenatal diagnosis is vital to obtain healthy generation for risky pregnancies. There have been several approaches some of which are routinely applied in clinics to evaluate the possible prenatal deficiencies and/or diseases. In the present study, we aimed to isolate the fetal cells from endocervical samples and try to identify possible anomalies which were proved by AS and CVS methods.

Endoservical specimens were collected from 100 pregnant women. Cells were separated in parallel by FACS and MACS using HLA G233 and PLAP antibodies. CMA analyses were carried out and male fetuses were confirmed with SRY amplification.

The percent of HLA G233 and PLAP positive cells were 4.55% and 84.59%, respectively. The percent of cells positive for both markers was 14.75%. CMA analyses were not informative. SRY was amplified in 67% of the samples.

However, the success rate of the both cell sorting and scanning of DNA anomalies by aCGH and/or RT-PCR was limited, preventing the applicability of this proposal in the clinics. Still, the success of the proposed method depends on the development of the novel fetal cell-specific antibodies and the improvements in the sorting systems.

However, the success rate of the both cell sorting and scanning of DNA anomalies by aCGH and/or RT-PCR was limited, preventing the applicability of this proposal in the clinics. Still, the success of the proposed method depends on the development of the novel fetal cell-specific antibodies and the improvements in the sorting systems.

In children with autosomal dominant polycystic kidney disease (ADPKD), clinical manifestations range from severe neonatal presentation to renal cysts found by chance. We aimed to evaluate demographic, clinical, laboratory findings, and genetic analysis of children with ADPKD.

We evaluated children diagnosed with ADPKD between January 2006 and January 2019. The diagnosis was established by family history, ultrasound findings, and/or genetic analysis. The demographic, clinical, and laboratory findings were evaluated retrospectively. Patients <10 years and ?10 years at the time of diagnosis were divided into 2 groups and parameters were compared between the groups.

There were 41 children (M/F18/23) diagnosed with ADPKD. The mean age at diagnosis was 7.2±5.1 (0.6?16.9) years and the follow-up duration was 59.34±40.56(8-198) months. Five patients (12%) were diagnosed as very early onset ADPKD. All patients had a positive family history. Genetic analysis was performed in 29 patients (PKD1 mutations in 21, PKD2 mutations in 1, no mutation in 3). Cysts were bilateral in 35 (85%) of the patients. Only one patient had hepatic cysts. No valvular defect was defined in 12 patients detected. Only 1 patient had hypertension. None of them had chronic kidney disease. No difference could be demonstrated in gender, laterality of the cysts, maximum cyst diameter, cyst or kidney enlargement, follow-up duration, or GFR at last visit between Groups 1 and 2.

The majority of children with ADPKD had preserved renal functions and slight cyst enlargement during their follow up. click here However, may have different renal problems deserving closed follow-up.

The majority of children with ADPKD had preserved renal functions and slight cyst enlargement during their follow up. However, may have different renal problems deserving closed follow-up.

There is no study in the literature in which only chest CT findings of deceased cases obtained at admission were examined and the relationship between these findings and mortality was evaluated. Metod In this retrospective study, a total of 117 deceased patients with COVID-19 infection confirmed by positive polymerase chain reaction and undergone chest CT were enrolled. We evaluated initial chest CT findings and the relationship of each, its location, prevalence and frequency with mortality.

The mean age of patients was 73 ±18 years, 71 of all patients were male and 46 were female.The predominant feature was pure GGO lesion (82.0%), and 59.8% of cases had pure consolidation. There was no cavitation, or architectural distorsion. Pericardial effusion was found in 9.4%, and pleural effusions were found in 15.3% of patients. Mediastinal lymphadenopathy was only 11.9% in total.

In deceased patients, on admission CTs, pure consolidation, pleural and pericardial effusion, mediastinal LAP were more common than ordinary cases. It was these findings that should also raise the concern when they were seen on chest CT, therefore, these radiologic features have the potential to represent prognostic imaging markers in patients with COVID-19 pneumonia.

In deceased patients, on admission CTs, pure consolidation, pleural and pericardial effusion, mediastinal LAP were more common than ordinary cases. It was these findings that should also raise the concern when they were seen on chest CT, therefore, these radiologic features have the potential to represent prognostic imaging markers in patients with COVID-19 pneumonia.

Based on the antiviral and antibacterial properties of aluminum salts, we aimed to find out the influence of aluminum salts on COVID-19 infected patients.

We performed an observational retrospective cohort study which includes the patients diagnosed as COVID-19 and received aluminum salts in addition to actual treatments during hospitalization as the treatment group (Alum Group). Patients who received standard COVID-19 treatment protocols in the Infectious Diseases Clinics were included as the Control Group. Clinical findings, laboratory parameters, length of stay, survival, radiological follow-up, intensive care and mechanical ventilation needs, the presence of comorbidity, polymerase chain reaction (PCR) tests, symptoms, symptom recovery times, hospital stay times, treatment protocols, and clinical presence of pneumonia were examined in all patients. Advanced chemical composition analyzes of existing aluminum salts were also performed.

A total of 109 patients, 54 in the alum group and 55 in the control group, were included in the study.