Bonnerpope1973

Copper sulfide nanoclusters with multi-enzyme-like routines and its application throughout acid solution phosphatase detecting determined by enzymatic stream effect.

Their pancreatic uptake, ∼3 %ID g-1 , is promising to envisage amylin imaging in diabetic animals.

To evaluate the feasibility of a new simple ultrasound-guided transforaminal injection in patients with cervical radiculopathy.

Ultrasound scans of the neck in a plastic model and in 5 unaffected participants were first performed to identify the intervertebral foramen. Then ultrasound-guided transforaminal injections were performed in 20 patients with radiculopathy in the lower cervical spine, and computed tomography was used to verify the accuracy. read more Complications, the visual analog score, and the neck disability index were assessed at 1 and 3 months after the injection.

Computed tomography confirmed that the needle tip was correctly placed in the intervertebral foramen in 88.5% (23 of 26) of injections. No immediate or short-term complications were observed in all patients. The visual analog score and neck disability index at 1 and 3 months were significantly lower than those before the injection (both P < .0001).

Ultrasound may be a feasible and accurate method to guide cervical transforaminal injection.

Ultrasound may be a feasible and accurate method to guide cervical transforaminal injection.

The most recent European League Against Rheumatism (EULAR) recommendations for gout advise against maintaining serum urate (SU) < 3 mg/dL for prolonged periods. While several Asian cohort studies reported higher mortality in individuals with extremely low SU, non-Asian data are scarce, and the relationship between hypouricemia, cardiovascular risk, and mortality remains unclear.

Using the National Health and Nutrition Examination Survey (NHANES) from 1988-1994 and 1999-2008, we examined the relations between SU and overall and cause-specific mortality among 41,807 adults in the United States (US). We calculated multivariable hazard ratios (HR) compared to a referent SU level of 5-6 mg/dL for SU categories <4, 4-5, 6-7, 7-8, and >8 mg/dL in men and <3, 3-4, 4-5, 6-7, >7 mg/dL in women.

Among women, there was no higher mortality risk at SU <3 mg/dL (HR 1.09, 95% confidence interval [CI] 0.92 to 1.28). Among men, there was a 28% higher mortality risk at SU<4 mg/dL (HR 1.28, 95% CI 1.13 to 1.45), with nearly three-times higher mortality from diabetes (HR 2.89, 95% CI 1.59 to 5.23), but no increase in mortality from any other specific cause.

We found no long-term excess mortality risk among US women with SU as low as <3 mg/dL, which is incompatible with causality between hypouricemia and premature mortality in women. We found excess all-cause and diabetes-related mortality among hypouricemic US men, which may, in part, be attributable to the uricosuric effect of hyperglycemia in fatal uncontrolled diabetes (analogous to reverse causality).

We found no long-term excess mortality risk among US women with SU as low as less then 3 mg/dL, which is incompatible with causality between hypouricemia and premature mortality in women. We found excess all-cause and diabetes-related mortality among hypouricemic US men, which may, in part, be attributable to the uricosuric effect of hyperglycemia in fatal uncontrolled diabetes (analogous to reverse causality).

Assess national trends in opioid prescription following pediatric tonsillectomy 1) overall percentage receiving opioids and mean quantity, 2) changes during 2009-2017, and 3) determinants of prescription patterns.

Cross-sectional analysis using 2009-2017 Optum claims data to identify opioid-naïve children aged 1-18 with claims codes for tonsillectomy (n = 82,842). Quantities of opioids filled in outpatient pharmacies during the perioperative period were extracted and converted into milligram morphine equivalents (MMEs) for statistical comparison. Demographic, clinical, and socioeconomic predictors of opioid fill rate and quantity were determined using regression analyses.

In 2009, 83.3% of children received opioids, decreasing to 58.3% by 2017. Rates of all-cause readmissions and post-tonsillectomy hemorrhages were similar over time. Mean quantity received was 153.47MME (95% confidence intervals [95%CI] 151.19, 155.76) and did not significantly change during 2009-2017. Opioids were more likely in older children and those with higher household income, but less likely in children with obstructive sleep apnea, other comorbidities, and Hispanic race. read more Higher quantities of opioids were more likely in older children, while lower quantities were associated with female sex, Hispanic race, and higher household income. Outpatient steroids were prescribed to 8.04% of patients, who were less likely to receive opioids.

While the percentage of children receiving post-tonsillectomy opioids decreased during 2009-2017, prescribed quantities remain high and have not decreased over time. Prescription practices were also influenced by clinical and sociodemographic factors. These results highlight the need for guidance, particularly with regard to opioid quantity, in children after tonsillectomy.

N/A Laryngoscope, 2020.

N/A Laryngoscope, 2020.

To explore system/staff- and patient-level opportunities to improve colorectal cancer (CRC) screening within an 11-clinic Federally Qualified Health Center (FQHC) in rural Appalachia with CRC screening rates around 22%-30%.

Using a convergent parallel mixed-methods design, staff (n = 26) and patients (n = 60, age 50-75, 67% female, 83% <college, 47% Medicare, 23% Medicaid) were interviewed about CRC-related screening practices. Staff and patient interviews were guided by the Consolidated Framework for Implementation Research and Health Belief Model, respectively, and analyzed using a hybrid inductive-deductive approach.

Among staff, inner setting factors that could promote CRC screening included high workplace satisfaction, experiences tracking other cancer screenings, and a highly active Performance Improvement Committee. Inner setting hindering factors included electronic medical record inefficiencies and requiring patients to physically return fecal tests to the clinic. Outer setting CRC screeningng staff and patients. To optimize multilevel CRC screening interventions in rural Appalachia clinics, future quality improvement, research, and policy efforts are needed to address identified challenges.