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Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling. Modulations are achieved at multiple levels, from cellular transcription to tissue-scale behavior. Olaparib Intracellularly, the endolysosomal system emerges as an important regulator at different levels, but in vivo studies are rare. In the frog Xenopus, little is known about the developmental roles of endosomal regulators, or their potential involvement in signaling, especially for late endosomes. Here, we analyzed a hypothesized role of Rab7 in this context, a small GTPase known for its role as a late endosomal regulator. First, rab7 showed strong maternal expression. Following localized zygotic transcript enrichment in the mesodermal ring and neural plate, it was found in tailbud-stage neural ectoderm, notochord, pronephros, eyes and neural crest tissues. Inhibition resulted in strong axis defects caused by a requirement of rab7 for mesodermal patterning and correct gastrulation movements. To test a potential involvement in growth factor signaling, we analyzed early Wnt-dependent processes in the mesoderm. Our results suggest a selective requirement for ligand-induced Wnt activation, implicating a context-dependent role of Rab7.A new tripodal C-anionic ligand, 2-bis(benzothiazolyl)(methoxy)methylphenyl (L), was stably generated by the reaction of the ligand precursor (L'), the corresponding bromide (2-BrC6H4)(MeO)C(C7H4NS)2 (C7H4NS = 2-benzothiazolyl), with nBuLi at -104 °C in the presence of TMEDA (N,N,N',N'-tetramethylethylenediamine). The ligand lithium salt reacted with BiCl3 to give a 2  1 complex L2BiCl. A 1  1 complex LBiCl2 was obtained in good yield by the redistribution reaction between L2BiCl and BiCl3. X-ray diffraction analysis revealed that the ligand L coordinated in an expected κ3-C,N,N' coordination mode in LBiCl2, while it coordinated in κ3-C,N,O and κ2-C,O coordination modes in L2BiCl. The ligand precursor reacted with BiX3 (X = Cl, Br) to give 1  1 complexes L'BiX3 and was found to act as a neutral tripodal C(π),N,N-ligand.Vertical van der Waals heterojunctions (HJs) composed of a photocatalytic star material BiOCl monolayer and group-IV Xene monolayer (silicene, germanene etc.) were studied by using first-principles calculations. Formation energy analysis and molecular dynamics simulation show that the BiOCl/Xene bilayer HJs can exist stably up to room temperature. Owing to evident charge redistribution and accumulation occurring between the bilayers, electron-hole puddles form and charge carrier transfer and separation occur in the HJs, which are beneficial to the improvement of photocatalytic performance. The HJ energy bands maintain the Dirac cones with almost linear dispersion curves, suggesting low effective mass and high mobility of carriers, and can be effectively tuned by strain. Our results show that the BiOCl/Xene bilayer HJs with high separation efficiency and high mobility of carriers and strain-adjustable bandgaps provide varieties in the functionalities of 2D van der Waals HJs and show great potentials in photocatalytic applications.Ba2BS3Cl and Ba5B2S8Cl2 have been synthesized by using PbCl2 as the flux and source of halogen. The two compounds show 3D network structures built by isolated [BS3] units with different Ba-S-Cl groups. This work enriches the structural diversity of boron chemistry and provides an insight into the synthesis of thioborates.Three coordination polymers (CPs) were synthesized by using CdII, fluorescent 9,10-di(4-pyridyl)anthracene (dpa), and cyclohexane-1,4-dicarboxylic acid (H2cda), and they are [Cd2(dpa)2(cda)Cl2]n (1), [Cd(dpa)2(cda)]n (2) and [Cd(dpa)(cda)(H2O)]n (3). Both 1 and 2 are fluorescent and contain nonporous layers. 3 is an isomer of 2 and contains a porous diamondoid network. Fluorescent mixed matrix membranes were prepared by dispersing the particles of 1 or 2 within the matrix of polymethyl methacrylate, and showed high sensitivity and selectivity for detecting Cr2O72- in water. Both stability and recyclability of the MMMs were remarkably higher than those of the CP powders.The regio- and diastereoselective synthesis of oxazolidinones via a Pd-catalyzed vicinal C-N/C-Cl bond-forming reaction from internal alkenes of allylic carbamates is reported. The oxazolidinones are obtained in yields of 44 to 95% with high to excellent diastereoselectivities (from 6  1 to >20  1 dr) from readily available precursors. This process is scalable, and the products are suitable for the synthesis of useful amino alcohols. A detailed theoretical and experimental mechanistic study was carried out to describe that the reaction proceeds through an anti-aminopalladation of the alkene followed by an oxidative C-Pd(ii) cleavage with retention of the carbon stereochemistry to yield the major diastereomer. The role of Cu(ii) in a C-Cl bond-forming mechanism step has also been proposed.Emulating the biological behavior of the human brain with artificial neuromorphic devices is essential for the future development of human-machine interactive systems, bionic sensing systems and intelligent robotic systems. In this paper, artificial flexible transparent carbon nanotube synaptic transistors (F-CNT-STs) with signal transmission and emotional learning functions are realized by adopting the poly(vinyl alcohol) (PVA)/SiO2 proton-conducting electrolyte. Synaptic functions of biological synapses including excitatory and inhibitory behaviors are successfully emulated in the F-CNT-STs. Besides, synaptic plasticity such as spike-duration-dependent plasticity, spike-number-dependent plasticity, spike-amplitude-dependent plasticity, paired-pulse facilitation, short-term plasticity, and long-term plasticity have all been systematically characterized. Moreover, the F-CNT-STs also closely imitate the behavior of human brain learning and emotional memory functions. After 1000 bending cycles at a radius of 3 mm, both the transistor characteristics and the synaptic functions can still be implemented correctly, showing outstanding mechanical capability. The realized F-CNT-STs possess low operating voltage, quick response, and ultra-low power consumption, indicating their high potential to work in low-power biological systems and artificial intelligence systems. The flexible artificial synaptic transistor enables its potential to be generally applicable to various flexible wearable biological and intelligent applications.