Phillipscooney8081

We present a straightforward, fast, inexpensive, and environmentally friendly synthesis of 1,2,3,4,5-pentasubstituted derivatives of pyrrole, which were produced in one-pot reactions of 3-oxoanilides with hydrazides of carboxylic acids, catalyzed by 10 mol % VOSO4·H2O. The reactions were carried out in ethanol in contact with air as the oxidant. The 19 pyrroles obtained were usually crystalline and did not require purification. The reaction tolerates various substituents in both substrates. All products were characterized by infrared, nuclear magnetic resonance, and ultraviolet-visible spectroscopy and elemental analysis. The molecular structures of the products and the intermediates were unambiguously determined by X-ray single-crystal analysis.Anion photoelectron spectroscopy and theoretical calculations were used to investigate the structural and bonding properties of Al4C6-/0 clusters. The vertical detachment energy of Al4C6- was measured to be 3.36 ± 0.08 eV. The structure of the Al4C6- anion is confirmed to be a bowl-shaped distorted triangle with an Al atom at the center and three Al atoms at the vertices. The global minimum isomer of neutral Al4C6 has a planar triangle-shaped structure with D3h symmetry. Both anionic and neutral Al4C6 have a hexacoordinated Al atom surrounded by three C≡C groups. Compared with the structure of neutral Al4C6, the structure of Al4C6- is distorted due to the addition of the excess electron. The molecular orbital analysis shows that the singly occupied molecular orbital of Al4C6- mainly locates on one side of the triangle plane and the neutral Al4C6 has a large highest occupied molecular orbital and lowest unoccupied molecular orbital gap. Theoretical calculations indicate that neutral Al4C6 has some aromaticity.We present an experimental study of the maximum and minimum bounding drop spacing for a parallel-sided liquid line produced by inkjet printing with drop volumes of 1.5 and 8.5 pL, on substrates with advancing contact angles of 46 and 54°, and zero receding contact angle. The results are used to validate models of the limiting bounds for the formation of stable parallel-sided lines as a function of drop spacing and transverse printing speed. read more The model for the maximum drop spacing bound (minimum line width) shows a good agreement with our results, but, when used to predict the stable line width, there is an influence of printing speed not captured by the model. This is probably because of a coupling between printed drop volume and ejection velocity outside the scope of the model. The minimum drop spacing bound (maximum stable line width) is limited by a bulging instability, and our results agree with the existing model, except for printing with the largest drop volumes at low temperature. It is shown that under these conditions, there is a different mechanism for bulging that occurs after printing over a period of minutes, if the liquid bead is present on the surface for a significant period of time before drying. Our results suggest that this mechanism is possibly triggered by imperfections on the substrate.The regioselective arylation of inert C3-H bonds in indoles reacting with arylboronates via effective copper-mediated catalysis with the aid of a facile and removable 2-pyridinylisopropyl (PIP) group without ligand participation is reported. This newly established method features high compatibility with diverse functional groups between coupling partners, including both indole substrates and arylboron reagents, consequentially leading to operational simplicity and providing access to generate the desired arylated products in good to excellent yields of up to 97%. Synthetically, the PIP-derived amide moiety could subsequently be readily removed under mild reaction conditions to produce useful indole carboxylic acids for further transformation.Achieving a high-quality metal contact on two-dimensional (2D) semiconductors still remains a major challenge due to the strong Fermi level pinning and the absence of an effective doping method. Here, we demonstrate high performance "all-PtSe2" field-effect transistors (FETs) completely free from those issues, enabled by the vertical integration of a metallic thick PtSe2 source/drain onto the semiconducting ultrathin PtSe2 channel. Owing to its inherent thickness-dependent semiconductor-to-metal phase transition, the transferred metallic PtSe2 transforms the underlying semiconducting PtSe2 into metal at the junction. Therefore, a fully metallized source/drain and semiconducting channel could be realized within the same PtSe2 platform. The ultrathin PtSe2 FETs with PtSe2 vdW contact exhibits excellent gate tunability, superior mobility, and high ON current accompanied by one order lower contact resistance compared to conventional Ti/Au contact FETs. Our work provides a new device paradigm with a low resistance PtSe2 vdW contact which can overcome a fundamental bottleneck in 2D nanoelectronics.Acute myeloid leukemia (AML) is an aggressive disease with a poor prognosis and a high degree of relapse seen in patients. Overexpression of FMS-like tyrosine kinase 3 (FLT3) is associated with up to 70% of AML patients. Wild-type FLT3 induces proliferation and inhibits apoptosis in AML cells, while uncontrolled proliferation of FLT3 kinase activity is also associated with FLT3 mutations. Therefore, inhibiting FLT3 activity is a promising AML therapy. Flavonoids are a group of phytochemicals that can target protein kinases, suggesting their potential antitumor activities. In this study, several plant-derived flavonoids have been identified with FLT3 inhibitory activity. Among these compounds, compound 40 (5,7,4'-trihydroxy-6-methoxyflavone) exhibited the most potent inhibition against not only FLT3 (IC50 = 0.44 μM) but also FLT3-D835Y and FLT3-ITD mutants (IC50 = 0.23 and 0.39 μM, respectively). The critical interactions between the FLT3 binding site and the compounds were identified by performing a structure-activity relationship analysis. Furthermore, the results of cellular assays revealed that compounds 28, 31, 32, and 40 exhibited significant cytotoxicity against two human AML cell lines (MOLM-13 and MV-4-11), and compounds 31, 32, and 40 resulted in cell apoptosis and G0/G1 cell cycle arrest. Collectively, these flavonoids have the potential to be further optimized as FLT3 inhibitors and provide valuable chemical information for the development of new AML drugs.