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Although significant, the variance of PGU and clausal density scores uniquely accounted for by SES was close to minimum. Clinicians can therefore include these three grammatical measures for assessing children of different socioeconomic backgrounds. Supplemental Material https//doi.org/10.23641/asha.14810484.Purpose This systematic review focuses on the effect of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on language function in Parkinson's disease (PD). It fills an important gap in recent reviews by considering other language tasks in addition to verbal fluency. Method We critically and systematically reviewed the literature on studies that investigated the effect of bilateral STN-DBS on language function in PD. All studies included a matched PD control group who were on best medical treatment, with language testing at similar baseline and follow-up intervals as the DBS PD group. Results Thirteen identified studies included a form of a verbal fluency task, seven studies included picture naming, and only two studies included more language-oriented tasks. We found that verbal fluency was negatively affected after DBS, whereas picture naming was unaffected. Studies investigating individual change patterns using reliable change indices showed that individual variability is larger for picture naming than for verbal fluency. Conclusions Verbal fluency is the most frequently investigated aspect of language function. Our analysis showed a pattern of decline in verbal fluency across multiple studies after STN-DBS, whereas picture naming was unaffected. Data on more language-oriented tests in a large DBS sample and best medical treatment control group are sparse. The investigation of language function in PD after DBS requires sensitive language tests (with and without time pressure) and experimental designs as used in the studies reviewed here. Reliable change index statistics are a promising tool for investigating individual differences in performance after DBS. Supplemental Material https//doi.org/10.23641/asha.14794458.Dr. Wolf Singer (b. 1943) is one of Germany's most renowned brain researchers and neurophysiologists. His accomplishments in the creation of new research centers for neuroscience as well as his commitment to European scientific organizations for integrative brain research are highly valued as significant moments of advancement in the neurosciences. Before his appointment as a scientific member of the Max Planck Society and director at the Frankfurt Max Planck Institute for Brain Research, he gained deep insight into the chances and pitfalls of translational initiatives at the Max Planck Institute of Psychiatry in Munich. From the late 1950s onward, the institute adapted to emerging international trends and successfully integrated neurochemistry, neurophysiology, and neuroanatomy into the fledgling interdisciplinary field of neuroscience. This agenda of reorientation was an undertaking of Otto Detlev Creutzfeldt, Detlev Ploog, Gerd Peters, and Horst Jatzkewitz, among others. In the 1970s, Munich's laboratories attracted scientists from several countries in Europe and abroad. This article examines whether specific styles of conducting (neuro)science research existed in the Max Planck Society.Pain remains a global health challenge affecting approximately 1.5 billion people worldwide. Pain has been an implicit variable in the equation of human life for many centuries considering different types and the magnitude of pain. Therefore, developing an efficacious drug delivery system for pain management remains an open challenge for researchers in the field of medicine. Lack of therapeutic efficacy still persists, despite high throughput studies in the field of pain management. Research scientists have been exploiting different alternatives to curb the adverse side effects of pain medications or attempting a more substantial approach to minimize the prevalence of pain. Various drug delivery systems have been developed such as nanoparticles, microparticles to curb adverse side effects of pain medications or minimize the prevalence of pain. This literature review firstly provides a brief introduction of pain as a sensation and its pharmacological interventions. Second, it highlights the most recent studies in the pharmaceutical field for pain management and serves as a strong base for future developments. Herein, we have classified drug delivery systems based on their sizes such as nano, micro, and macro systems, and for each of the reviewed systems, design, formulation strategies, and drug release performance has been discussed.

Disturbances in interpersonal functioning are prevalent in individuals with suicidality. Foundational for interpersonal functioning is theory of mind (ToM), a social-cognitive ability that allows individuals to understand the thoughts and feelings of others. Recent work has begun to investigate ToM performance in individuals with suicidality, though no review has quantitatively aggregated findings from these varied studies. read more The current study investigated the relations between ToM and suicidality with meta-analysis. Method We identified and meta-analyzed 15 studies that presented data for 2,895 participants (617 of whom had reported at least one suicide attempt). Results Results indicated a significant, negative relation between ToM and suicidality with a medium overall effect size (

= -.475). Moderator analyses revealed that this effect was consistent across age, sex, ToM content, and suicidal outcome. Conclusion Deficits in ToM associated with suicidality hold promise for risk-identification, treatment, gative relation between ToM and suicidality with a medium overall effect size (g = -.475). Moderator analyses revealed that this effect was consistent across age, sex, ToM content, and suicidal outcome. Conclusion Deficits in ToM associated with suicidality hold promise for risk-identification, treatment, and prevention work.HIGHLIGHTSTheory of mind (ToM) abilities are critical for effective interpersonal functioning.Meta-analytics results indicate that ToM deficits are associated with suicidality.Identifying such suicidality-related ToM deficits may inform risk-identification, treatment, and prevention work.