Marquezphillips0428

n area, provoking almost total closure of the scratches within 48 h without cytotoxicity. In this study, we used cerium oxide nanoparticles and evaluated their anti-cancer effects in a mouse model of fibrosarcoma. For evaluation of anti-cancer effects of nanoceria, tumor volume measurement, TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) assay, quantitative real-time PCR (qPCR) for Bax and Bcl2 genes, a panel of liver and kidney function tests and hematoxylin-eosin staining were done. Nanoceria dominantly accumulated in the tumor and it could significantly decrease tumor growth and volume in tumor-bearing mice that received nanoceria for four weeks. Cerium oxide nanoparticle showed potential anti-cancer properties against fibrosarcoma. New peptide based hybrid scaffolds were prepared by blending two different fish scale derived hydroxyapatite with functionalized peptide nanofibers for potential applications in periodontal tissue regeneration. The nanofibers were prepared by self-assembly of the newly designed peptide bolaamphiphile Bis (N-α-amido-glutamic acid) 1,7 heptane tetracarboxylate and functionalized with a segment of the tyrosine rich amylogenin peptide sequence MPLPPHPGHPGYINF followed by polygalacturnonic acid and hydroxyapatite derived from salmon or red-snapper fish scales. The binding interactions of the components of the scaffold was confirmed by FTIR spectroscopy as well as SEM imaging. Hybrids scaffolds with salmon scale derived HaP showed higher mechanical strength and Young's Modulus compared to snapper scale derived scaffolds. Our results indicated that while both the scaffolds supported cell proliferation and efficiently formed cell-scaffold matrices with gingival fibroblasts, we observed greater alignment of the cells in the case of scaffolds that contained snapper scale derived hydroxyapatite. VPS34-IN1 cell line Furthermore, higher differentiation ability into osteoblast like cells was seen in the case of the snapper scale derived HaP based scaffolds. Our studies indicate that the hybrid peptide nanofiber scaffold matrices, particularly those prepared using snapper scales may have significant utility in the development of biomaterials for periodontal tissue regeneration. This study highlights the incorporation of copper in the bioactive glasses (BAG) network that greatly influences the morphological, structural and biological properties. By increasing the copper incorporation in BAG, increment in cell volume was obtained from XRD patterns, and concomitantly, dominant phosphate bands and latent silica bands were observed by FT-IR and Raman spectroscopic results. The Cu addition also affected particle appearance to vary from spherical to cluster-like cubes in 1.5% and 2.5% copper-doped BAG. Due to the mesoporous network 1.5% and 2.5% copper-doped BAG showed enhanced release of anti-inflammatory drugs such as Acetaminophen (ACE) and Ibuprofen (IBU) in which, the drug release profiles showed best fit with kinetic models of First order, Korsmeyar-Peppas and Higuchi. Copper doping influences the lattice of BAG, as a result morphology and porosity varied, which regulates the ionic dissolution, hence, prompting bioactivity was perceived from 1.5% and 2.5% copper-doped bioactive glasses (Cu-BGs). Moreover, 2.5% Cu-BG and 1.5% Cu-BG showed highest rate of ROS detection, as well as improved antimicrobial activity. This study established that up to certain proportion of copper incorporation in BAG network, potentially enhances the biomineralization and turns the morphology towards minimal size with mesoporous nature. Due to the abundance in oral microbial exposure, copper amplifies the superior antimicrobial properties, and Cu-BGs act as a drug carrier to load ACE and IBU, which potentially up-regulate the healing properties in dental application. Here, we report a facile one-step solid-state reaction assisted synthesis of β-NaFeO2 perovskite for simultaneous sensing of Dopamine (DA), Uric Acid (UA), Xanthine (Xn) and Hypoxanthine (Hxn) in human blood. The orthorhombic phase formation in β-NaFeO2 with the presence of octahedral sites is confirmed through x-ray diffraction (XRD) and Raman spectroscopy while high surface area pebble-like morphology is observed through scanning electron microscopy (SEM). The sensor exhibits distinct oxidation potentials for DA, UA, Xn and Hxn with a peak separation (ΔEp) between DA-UA, UA-Xn and Xn-Hxn as 134 mV, 388 mV and 360 mV, respectively. The sensor exhibits an excellent selectivity, sensitivity and low limits of detection (LOD) of 2.12 nM, 158 nM, 129 nM and 95 nM for DA, UA, Xn and Hxn, respectively which are well below the lower limits of their presence in physiological ranges in human body fluids. The sensor shows an excellent selectivity and it was successfully employed in simultaneous sensing of DA, UA, Xn and Hxn in simulated blood serum samples with excellent recovery percentages. This is the first report on low-cost β-NaFeO2 modified GCE for simultaneous electrochemical sensing of biomolecules which can be applied for numerous bioanalytical applications. Inspired by the adhesion mechanism of natural mussels, polydopamine (PDA) has been widely studied and applied in hydrogels due to its good adhesion to various materials. In this work, a double-layer hydrogel constituted of an adhesive layer and a tough layer was successfully prepared via in-situ polymerization. Adding polystyrene particles into the tough layer could improve the mechanical properties, and the adhesion of various substrates could be achieved with PDA nanoparticles in the adhesive layer. Furthermore, lithium chloride was introduced into the tough layer to endow the bilayer hydrogels with electrical conductivity. Due to the hydrophobic association in the tough layer and hydrogen bond in the adhesive layer, the double-layer hydrogel exhibits self-healing properties. In addition, the NIR light response property of PDA was beneficial to self-healing properties. As a result, it has proved that the prepared bilayer hydrogel has excellent conductivity, toughness (0.18 MPa), adhesion and self-healing properties, which is an ideal flexible wearable strain sensor with high sensitivity and good repeatability, suitable for human motion signal detection.