Deckerortiz6674

The northern Gulf of Mexico has a long history of polycyclic aromatic hydrocarbon (PAH) contamination from anthropogenic activities, natural oil seepages, and the 2010 Deepwater Horizon explosion and oil spill. The continental shelf of the same area is a known breeding ground for sperm whales (Physeter macrocephalus). To evaluate PAH-DNA damage, a biomarker for potential cancer risk, we compared skin biopsies collected from Gulf of Mexico sperm whales in 2012 with skin biopsies collected from sperm whales in areas of the Pacific Ocean in 1999-2001. All samples were obtained by crossbow and comprised both epidermis and subcutaneous blubber. To evaluate exposure, 7 carcinogenic PAHs were analyzed in lipids extracted from Pacific Ocean sperm whale blubber, pooled by sex, and location. To evaluate PAH-DNA damage, portions of all tissue samples were formalin-fixed, paraffin-embedded, sectioned, and examined for PAH-DNA adducts by immunohistochemistry (IHC) using an antiserum elicited against benzo[a]pyrene-modified DNA, which crossreacts with several high molecular weight carcinogenic PAHs bound to DNA. The IHC showed widespread epidermal nuclear localization of PAH-DNA adducts in the Gulf of Mexico whales (n = 15) but not in the Pacific Ocean whales (n = 4). A standard semiquantitative scoring system revealed significantly higher PAH-DNA adducts in the Gulf of Mexico whales compared to the whales from the Pacific Ocean study (p = .0002).

Fibromuscular dysplasia (FMD) is a non-atherosclerotic systemic arterial disease that is not infrequently discovered during kidney donor evaluation. Current guidelines do not provide recommendations regarding the use of kidneys from donors with FMD and there is a paucity of data on the outcomes of these donors.

The Renal and Lung Living Donor Evaluation (RELIVE) Study addressed long-term outcomes of 8922 kidney donors who donated 1963 - 2007. We compared the development of hypertension, cardiovascular disease, proteinuria and reduced eGFR in 113 kidney donors with FMD discovered during donor evaluation to 452 propensity score matched donors without FMD. Outcomes modeling with logistic and Cox regression analysis and Kaplan Meier statistics were performed.

Donors with FMD were older (51 vs. 39 years), were more likely to be women (80% vs. 56%) and had a higher systolic blood pressure at donation (124.7 vs. 121.3 mmHg), p < 0.05 for all. After a mean follow-up of 15.5 ± 8.9 years, a similar proportion of donors with and without FMD were alive, developed hypertension (22.2% vs 19.8%), proteinuria (20.6% vs 13.7%) and CVD (13.3% vs 13.5%). Epigenetic inhibitor molecular weight No donor with FMD developed an eGFR <30 ml/min/1.73 m2 or ESKD. The multivariable risk of mortality, cardiovascular disease and renal outcomes in donors with FMD were not elevated.

Kidney donors with FMD appear to do well, do not appear to incur increased risks of hypertension, proteinuria, CVD or reduced eGFR and perhaps carefully selected candidates with FMD can safely donate as long as involvement of other vascular beds is ruled out.

Kidney donors with FMD appear to do well, do not appear to incur increased risks of hypertension, proteinuria, CVD or reduced eGFR and perhaps carefully selected candidates with FMD can safely donate as long as involvement of other vascular beds is ruled out.The Polycomb Repressive Complex 2 (PRC2) is well-known for its role in controlling developmental transitions by suppressing the premature expression of key developmental regulators. Previous work revealed that PRC2 also controls the onset of senescence, a form of developmental programmed cell death (PCD) in plants. Whether the induction of PCD in response to stress is similarly suppressed by the PRC2 remained largely unknown. In this study, we explored whether PCD triggered in response to immunity- and disease-promoting pathogen effectors is associated with changes in the distribution of the PRC2-mediated histone H3 lysine 27 trimethylation (H3K27me3) modification in Arabidopsis thaliana. We furthermore tested the distribution of the heterochromatic histone mark H3K9me2, which is established, to a large extent, by the H3K9 methyltransferase KRYPTONITE, and occupies chromatin regions generally not targeted by PRC2. We report that effector-induced PCD caused major changes in the distribution of both repressive epigenetic modifications and that both modifications have a regulatory role and impact on the onset of PCD during pathogen infection. Our work highlights that the transition to pathogen-induced PCD is epigenetically controlled, revealing striking similarities to developmental PCD.

In the 1980s, nurses became more recognized as interprofessional healthcare partners who actively participated in the advancement of patient care and the nursing profession. There is a significant gap in the nursing literature about the significant contributions of executive military nurse leaders. The purpose of the interview with Brigadier General (Brig Gen) Hale O'Connor was to explore the personal stories, experiences, leadership strategies, lessons learned, and impact of her leadership on the future development of nursing as a profession.

The oral history method provided a framework for the interview and the analysis. In compliance with the Oral History Association guidelines, the primary investigator obtained Institutional Review Board permission, participant informed consent, and an audiotaped interview. A graduate research assistant transcribed the 3-hour audiotaped interview verbatim. The participant reviewed the transcription, provided clarification, and validated accuracy. Three independent codncement of nursing during her tenure and for those who followed.

Although the team did not use the Reina Trust Model as a framework, the trust-building behaviors emerged from the transcribed interview during the analysis. Surprisingly, many of the leadership strategies utilized by Brig Gen Hale O'Connor fit well into the Reina Trust Model, published 25 years following O'Connor's tenure as Chief, Air Force Nurse Corps. In addition, several of Brig Gen Hale O'Connor's leadership accomplishments are still relevant today, solidifying the observation that the foresight of Brig Gen Hale O'Connor was fundamental to the advancement of nursing during her tenure and for those who followed.