Falkdrejer6790

Recent works have demonstrated that deep learning (DL) based compressed sensing (CS) implementation can accelerate Magnetic Resonance (MR) Imaging by reconstructing MR images from sub-sampled k-space data. However, network architectures adopted in previous methods are all designed by handcraft. Neural Architecture Search (NAS) algorithms can automatically build neural network architectures which have outperformed human designed ones in several vision tasks. Inspired by this, here we proposed a novel and efficient network for the MR image reconstruction problem via NAS instead of manual attempts. Particularly, a specific cell structure, which was integrated into the model-driven MR reconstruction pipeline, was automatically searched from a flexible pre-defined operation search space in a differentiable manner. Experimental results show that our searched network can produce better reconstruction results compared to previous state-of-the-art methods in terms of PSNR and SSIM with 4∼6 times fewer computation resources. Extensive experiments were conducted to analyze how hyper-parameters affect reconstruction performance and the searched structures. The generalizability of the searched architecture was also evaluated on different organ MR datasets. Our proposed method can reach a better trade-off between computation cost and reconstruction performance for MR reconstruction problem with good generalizability and offer insights to design neural networks for other medical image applications. The evaluation code will be available at https//github.com/yjump/NAS-for-CSMRI.

Neuropathic corneal pain (NCP) is a recently acknowledged disease entity. However, there is no consensus in potential treatment strategies, particularly in patients with a centralized component of pain. This study aims to assess the efficacy and tolerability of the tricyclic antidepressant, nortriptyline, among NCP patients.

Patients with clinically diagnosed NCP and a centralized component of pain, treated with oral nortriptyline, who had recorded pain scores as assessed by the ocular pain assessment survey at the first and last visit were included. Patients were excluded if they had any other ocular pathology that might result in pain or had less than 4 weeks of nortriptyline use. Demographics, time between visits, concomitant medications, systemic and ocular co-morbidities, duration of NCP, side effects, ocular pain scores, and quality of life (QoL) assessment were recorded.

Thirty patients with a mean age of 53.1±18.5 were included. Male to female ratio was 822. Mean ocular pain in the past 24h improved from 5.7±2.1 to 3.6±2.1 after 10.5±9.1 months (p<0.0001). Twelve patients (40.0%) had equal to or more than 50% improvement, 6 patients (20.0%) had 30-49% improvement, 6 patients (20.0%) had 1-29% improvement, 4 patients (13.3%) did not improve, while 2 patients (6.7%) reported increase in pain levels. Mean QoL improved from 6.0±2.5 to 4.3±2.4 (p=0.019). Eight patients (26.6%) discontinued treatment due to persistent side effects, despite improvement by 22.4%.

Nortriptyline was effective in relieving NCP symptoms in patients with centralized component and insufficient response to other systemic and topical therapies who tolerated the drug for at least 4 weeks. Nortriptyline may be used in the management of patients with NCP.

Nortriptyline was effective in relieving NCP symptoms in patients with centralized component and insufficient response to other systemic and topical therapies who tolerated the drug for at least 4 weeks. Nortriptyline may be used in the management of patients with NCP.

The long-term success of visual rehabilitation in patients with severe conjunctival scarring is reliant on the reconstruction of the conjunctiva with a suitable substitute. The purpose of this study is the development and investigation of a re-epithelialized conjunctival substitute based on porcine decellularized conjunctiva (PDC).

PDC was re-epithelialized either with pre-expanded human conjunctival epithelial cells (PDC+HCEC) or with a human conjunctival explant placed directly on PDC (PDC+HCEx). Histology and immunohistochemistry were performed to evaluate epithelial thickness, proliferation (Ki67), apoptosis (Caspase 3), goblet cells (MUC5AC), and progenitor cells (CK15, ΔNp63, ABCG2). The superior construct (PDC+HCEx) was transplanted into a conjunctival defect of a rabbit (n=6). Lissamine green staining verified the epithelialization in vivo. Orbital tissue was exenterated on day 10 and processed for histological and immunohistochemical analysis to examine the engrafted PDC+HCEx. A human-specific ang alternative conjunctival substitute for patients with extensive conjunctival stem and goblet cell loss.

To evaluate the value of myomectomy during delivery by cesarean section (CS) in pregnant women with uterine fibroids.

Retrospective cohort study of pregnant women diagnosed to have uterine fibroids during index pregnancy. Women who underwent myomectomy during CS (study group; n = 91) were compared with women in whom myomectomy was not performed during CS (control group; n = 87).

No significant difference between both groups in the amount of blood transfusion and postoperative hemoglobin level. The operative time was significantly higher in the myomectomy group than in the control group (80.22 ± 13.06 vs 56.67 ± 8.85 min; P <  0.001). Also, the postoperative hospital stay period was significantly higher in the myomectomy group (P <  0.001).

Myomectomy during CS can be performed safely without increase in the peripartum maternal morbidities. It only may prolong the operative time and postoperative hospital stay period but it may have many benefits including avoiding another operation to remove fibroids.

Myomectomy during CS can be performed safely without increase in the peripartum maternal morbidities. It only may prolong the operative time and postoperative hospital stay period but it may have many benefits including avoiding another operation to remove fibroids.Communication is a powerful tool for promoting cooperation in adults and is considered one of the most important solutions to social dilemmas. One feature that makes communication particularly useful in cooperative contexts is that it allows people to advertise their intentions to partners. Some work suggests that adults cooperate more after making nonbinding commitments to cooperate (i.e., commitments they do not need to uphold) than when they are not allowed to communicate their intentions to their partners. However, we know little about whether nonbinding commitments play a similar role in children. We addressed this gap by testing 6- to 9-year-old children in a simultaneous version of the iterated prisoner's dilemma game. Azeliragon in vitro In the communication condition, children could communicate their intended decision prior to their actual choice, whereas in the silent condition, they could not communicate. Overall, children in the communication condition were no more likely to cooperate than children in the silent condition.