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Recent studies have shown that YAP is closely related to the pathological process of cardiovascular diseases. But the role of YAP in cardiac injury of diabetic cardiomyopathy (DCM) is still unclear.

Diabetic cardiomyopathy rat model was established and divided into control group, DCM group, LV-SC-shRNA group and LV-YAP-shRNA group. LV-SC-shRNA group and LV-YAP-shRNA group were injected with lentivirus expressing SC-shRNA and YAP-shRNA via tail vein, respectively. Primary rat cardiac fibroblasts (CFs) were stimulated with high concentration of glucose and treated with recombinant lentivirus expressing either SC-shRNA or YAP-shRNA to observe the expression of CTGF and fibronectin, so as to observe the effect of inhibiting YAP on the pathogenesis of DCM.

Compared with control group, high glucose markedly increased YAP mRNA and protein expression in DCM and CFs. https://www.selleckchem.com/products/mhy1485.html Inhibition of YAP decreased myocardial fibrosis and improved cardiac function in the DCM model and decreased the expression of CTGF and fibronectin This study revealed that YAP plays an important role in the pathological process of diabetic cardiomyopathy, and down-regulation of YAP expression may provide a new therapeutic target for DCM.

Nephropathy is a frontline complication of diabetes mellitus (DM) associated with impaired redox-inflammatory networks. The study investigated the antidiabetic and nephroprotective potentials of PCR against diabetic nephropathy (DN) in rats.

DN was induced in rats using a combination of a high fructose solution for 4 weeks and an intraperitoneal injection of streptozotocin (35 mg/kg). Diabetic rats were treated with PCR (100 and 400 mg/kg body weight) for 8 weeks. Serum biochemical parameters as well as renal oxidative stress parameters, proinflammatory cytokines, Western blot and histopathological analyses were evaluated.

There were significant increases in fasting blood glucose, urinary albumin, serum creatinine, blood urea nitrogen (BUN), total cholesterol (TC), triglycerides (TG), and low-density lipoproteins (LDL-C) levels in diabetic rats compared to the non-diabetic control rats. DM-induced DN prominently depressed renal superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Pmmation. As such, PCR has potentials as a food supplement for alleviating renal dysfunction caused by diabetes.

Our results suggest that PCR displayed antidiabetic and nephroprotective effects against DN by impeding oxidative stress and inflammation. As such, PCR has potentials as a food supplement for alleviating renal dysfunction caused by diabetes.

Inadequate diabetes self-care knowledge leads to developing diabetic complications and death. Diabetic complications are directly related to the patient's level of diabetic self-care knowledge.

The purpose of this study was to assess diabetic self-care knowledge and its associated factors among adult diabetes mellitus patients on follow-up care at North Shewa Zone government hospitals, Oromia Region, Ethiopia, 2020.

An institution-based cross-sectional study was employed using a consecutive sampling technique from January 1 to February 30/2020 among 245 adult diabetes mellitus patients on follow-up care at North Shewa Zone government Hospitals, Oromia Region, Ethiopia. We used Epi data version 3.1 to enter the data and SPSS version 25 for analysis. Both bivariable and multivariable logistic regression was used to identify significant factors for knowledge of diabetic self-care.

In this study, from a total of 245 diabetic patients, 230 participated giving a response rate of 93.87%. More than half of the study respondents, 156 (67.8%), had good diabetes self-care knowledge and variables such as being employed (AOR; 0.146, 95%; CI 0.18-0.94), having information on diabetic self-care (AOR; 3.003, 95% CI 1.24-5.3) and urban residency (AOR; 0.27, 955 CI 0.099-0.532) were found to be independent factors affecting diabetic self-care knowledge.

The magnitude of diabetes self-care knowledge was not adequate and some critical knowledge gaps were also identified in specific areas which reflect that there is a need to improve diabetic self-care knowledge among patients by implementing adequately and continuous diabetic self-care education programs.

The magnitude of diabetes self-care knowledge was not adequate and some critical knowledge gaps were also identified in specific areas which reflect that there is a need to improve diabetic self-care knowledge among patients by implementing adequately and continuous diabetic self-care education programs.

Vaccination is one of the best ways to control a pandemic such as COVID-19. However, identifying community apprehensions towards vaccination needs to be understood in detail. This study aims to determine the factors that can predict the acceptance of the COVID-19 vaccine.

A cross-sectional study was considered by systematic random sampling of 425 adults with chronic illnesses in Ho Chi Minh City. Data were collected between December 2020 and January 2021 via a self-administered, structured questionnaire. The main outcome was the acceptance of future COVID-19 vaccinations.

A total of 425 eligible adults responded to the survey, whose mean age was 52.9±15.6 years; 67.8% of them were women, more than a half of them had high school education level or higher (57.4%) and received COVID-19 information mainly via television and social media accounted for 82.4% and 58.1%, respectively. Overall, knowledge of COVID-19 was reported as relatively good, with a mean score of 7.11 ± 1.77 (0-9). Determinants of vaccinatne acceptance.

In several countries, introduction of the pneumococcal conjugate vaccine (PCV) has led to a decline in antimicrobial-resistant pneumococcal disease but has also resulted in a concomitant increase in antimicrobial-resistant, non-vaccine serotypes of

. We sought to determine the magnitude of penicillin and macrolide resistance among pneumococcal serotypes and the mechanisms of macrolide resistance in Ethiopia, 5 years after the introduction of PCV10 in the country.

Susceptibility to penicillin and erythromycin of 119 pneumococcal isolates collected from pediatric patients aged 0-15 years in Addis Ababa, Ethiopia, was tested using disc diffusion, and minimum inhibitory concentration (MIC) was also determined by Etest. Pneumococcal serotypes were determined by sequencing the

B gene and using Quellung reaction. Polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism analysis were used to detect and differentiate the macrolide resistance genes

(B),

A), and

(B).

Among the 119 isolates, 2.