Spencerubin4781

The COVID-19 pandemic has resulted in unprecedented challenges for people living with cancer, impacting not only physical health but psychological well-being. The psychological response affects the individual as well as the community and can persist long after the outbreak. We aim to assess coping strategies employed by women with ovarian cancer during the COVID-19 pandemic.

Women with a current or prior diagnosis of ovarian cancer completed an online survey which included a query about coping strategies during the COVID-19 pandemic. The survey was distributed from March 30th through April 13, 2020 through survivor networks and social media.

Six hundred and three women visited the survey website during the study period and 555 (92.0%) completed the survey. Four hundred and eight (73.5%) provided information on coping strategies utilized during COVID-19. Among those who responded, the median age was 58years (range 20-85) and 150 participants (40.8%) were undergoing active cancer treatment. Commonly utiliptimize physical and psychological well-being.There is growing evidence for a main role of environment in the occurrence of mental disorders such as a psychosocial risk factor, for example, childhood trauma, discrimination linked to minority status, or migrant status. One hypothesis is that social adversity factors influence the risk of schizophrenia through a common pathway social defeat which could be defined as the impotence of a subject in the face of a situation of social adversity, with a consequential experience of devaluation on the social scale. This review proposes to explain the animal model of social defeat which provides an overview of the neurobiological consequences of chronic stress. Then, we expose this topic in humans, the assessment methods, and its psychopathological field. Finally, we expose epidemiologic and neurobiological evidences, in particular the dopaminergic sensitization process, which provide evidence of a significant role of social defeat in schizophrenia risk due to exposure to psychosocial factors. This etiopathogenic hypothesis has several issues. First, a common pathway to several environmental risk factors could allow an ethiopathogenic model more parcimonious for schizophrenia. It could also allow the assessment and prevention of adversity factors involved in social defeat so as to finally improve the outcome of subjects who have an individual risk for schizophrenia.This study suggests a new control system for frequency regulation in AC microgrids. Unlike to the most studies, challenging conditions such as variation of wind speed, multiple load disturbance, unknown dynamics and variable solar radiation are taken to account. To cope with uncertainties, a novel dynamic general type-2 (GT2) fuzzy logic system (FLS) by an optimized secondary membership is suggested. The secondary membership and rule parameters of dynamic GT2-FLS are online tuned through the adaptive optimization rules. The optimization rules are determined such that the robustness and stability to be guaranteed. Also, a new compensator is presented to tackle with estimation error and perturbations. check details The simulations verify that schemed controller outperforms than conventional methods.The robust control of the crude oil outlet temperature uniformity in a heating furnace of a petroleum refinery is addressed. A reliable dynamic model of the nominal process has been attained using a system identification procedure based on real-time data. This procedure yields a second order model with a dominant time-delay. A PI controller embedded in a modified Smith predictor structure is therefore proposed. Sensitivity and robustness properties of this control system are analytically obtained. Based on that, a tuning procedure is developed for this control system which has lower sensitivity to disturbances than the standard Smith predictor while guaranteeing the system stability when plant parameters change. Simulations are carried out of the proposed control system and other well-known linear advanced process control systems. The comparison of the obtained results shows the superior performance of our control system in most cases, both in rejecting a variety of disturbances and in maintaining the closed-loop stability when the process parameters change.Hypercholesterolemia refers to dyslipidemia with an increased circulating cholesterol levels. This is the most common dyslipidemia and is associated with an increased risk of developing atheromatous cardiovascular diseases. One of the major challenges in primary prevention is to define the threshold for therapeutic intervention that allow to obtain a significant clinical benefit without unnecessarily expose the patient to potential side effects of lipid-lowering treatments. It is also important to recall to screen patient for heterozygous familial hypercholesterolemia, a common genetic disease of lipid metabolism responsible for particularly severe and early coronary disease. In this article, the issues of hypercholesterolemia screening, the definition of therapeutic targets and expected benefits as well as the modalities of therapeutic management (by also addressing the problem of statin intolerance) will be addressed.The present study comprehensively investigates the phototransformation and ecotoxicity of a mixture of twelve pharmaceutically active compounds (PhACs) susceptible to photolysis. Namely, three antibiotics (ciprofloxacin, levofloxacin, moxifloxacin), three antidepressants (bupropion, duloxetine, olanzapine), three anti-inflammatory drugs (diclofenac, ketoprofen, nimesulide), two beta-blockers (propranolol, timolol) and the antihistamine ranitidine were treated under simulated solar irradiation in ultra-pure and river water. A total of 166 different transformation products (TPs) were identified by ultra-high performance liquid chromatography coupled with Orbitrap high resolution mass spectrometry (UHPLC-Orbitrap HRMS), revealing the formation of twelve novel TPs and forty-nine not previously described in photolytic studies. The kinetic profiles of the major TPs resulting from a series of chemical reactions involving hydroxylation, cleavage and oxidation, dehalogenation, decarboxylation, dealkylation and photo substitution have been investigated and the transformation pathways have been suggested.