Molinastentoft8555

Agriculture remains critical to Africa's socioeconomic development, employing 65% of the work force and contributing 32% of GDP (Gross Domestic Product). Low productivity, which characterises food production in many Africa countries, remains a major concern. Compounded by the effects of climate change and lack of technical expertise, recent reports suggest that the impacts of climate change on agriculture and food systems in African countries may have further-reaching consequences than previously anticipated. Thus, it has become imperative that African scientists and farmers adopt new technologies which facilitate their research and provide smart agricultural solutions to mitigating current and future climate change-related challenges. Advanced technologies have been developed across the globe to facilitate adaptation to climate change in the agriculture sector. Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), synthetic biology, and genomic selection, among others, constitute examples of some of these technologies. In this work, emerging advanced technologies with the potential to effectively mitigate climate change in Africa are reviewed. The authors show how these technologies can be utilised to enhance knowledge discovery for increased production in a climate change-impacted environment. We conclude that the application of these technologies could empower African scientists to explore agricultural strategies more resilient to the effects of climate change. Additionally, we conclude that support for African scientists from the international community in various forms is necessary to help Africans avoid the full undesirable effects of climate change.Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), micro RNAs (miRNAs), and extracellular RNAs (exRNAs) are new groups of RNAs with regulation activities that have low or no protein-coding ability. Emerging evidence suggests that deregulated expression of these non-coding RNAs is associated with the induction and progression of diverse tumors throughout epigenetic, transcriptional, and post-transcriptional modifications. A consistent number of non-coding RNAs (ncRNAs) has been shown to be regulated by p53, the most important tumor suppressor of the cells frequently mutated in human cancer. It has been shown that some mutant p53 proteins are associated with the loss of tumor suppressor activity and the acquisition of new oncogenic functions named gain-of-function activities. NEO2734 chemical structure In this review, we highlight recent lines of evidence suggesting that mutant p53 is involved in the expression of specific ncRNAs to gain oncogenic functions through the creation of a complex network of pathways that influence each other.The impact of high-pressure (HP) processing on the viability of two probiotic microorganisms (Bifidobacterium bifidum and Lactobacillus casei) at varying pressure (100-400 MPa), temperature (20-40 °C) and pH (6.5 vs. 4.8) conditions was investigated. Appropriate mathematical models were developed to describe the kinetics of the probiotics viability loss under the implemented HP conditions, aiming to the development of a predictive tool used in the design of HP-processed yoghurt-like dairy products. The validation of these models was conducted in plain and sweet cherry-flavored probiotic dairy beverage products pressurized at 100-400MPa at ambient temperature for 10 min. The microbiological, rheological, physicochemical and sensory characteristics of the HP-treated probiotic dairy beverages were determined in two-week time intervals and for an overall 28 days of storage. Results showed that the application of HP in the range of 200-300 MPa had minimal impact on the probiotic strains viability throughout the entire storage period. In addition, the aforementioned HP processing conditions enhanced the rheological and sensory properties without affecting post-acidification compared to the untreated product analogues.Older people have a high incidence of adverse outcomes after urgent care presentation. Identifying high-risk older patients early is key to targeting interventions at those patients most likely to benefit. This study used the Frailsafe three-point screening questions amongst older Emergency Department (ED) attendees. Consecutive unplanned ED attendances in patients aged ≥75 were assessed for Frailsafe status. The primary outcome was mortality at 180 days. A Frailsafe screen was completed in 356 patients, of whom 194/356 (54.5%) were Frailsafe positive. The mean age was 85.8 for Frailsafe screen positive and 82.2 for Frailsafe screen negative patients (p 28 days (AOR 3.42, 95% CI 1.41-8.31, p = 0.007) and re-attendance within 30 days of discharge after admission (OR = 2.73, 95% CI 1.27-5.88, p = 0.01). Frailsafe screen results independently predict a range of outcomes amongst older ED attendees.The reaction of CA (monocalcium aluminate) with calcite was closely monitored with regard to phase development, pore water ion content and heat flow. Calcite acts as filler and reactant, finally leading to thermodynamically stable products after hydration at ambient conditions. For better understanding the mechanism taking place, a CA-cement and a commercial calcite mix were compared to a pure CA and pure calcite mix. Both reaction paths were compared. Thermodynamic modeling with PhreeqC gave insight about factors that can influence the course of the hydration reaction. Alkali ions in pore solution of the CA-cement relocate solubility curves of hydration products. Taking into account as many of the alkaline ions as possible, resulted in the closest representation of the measured phase content, confirming thermodynamic modeling. The high dynamics that develop during reaction could only be addressed if a concentration of alkalis in the pore solution at later points in time was respected, thus leading to a shift of solubility curves over time. This was not observed with the pure CA in absence of alkalis.Antibiotic resistance is on the rise, leading to an increase in morbidity and mortality due to infectious diseases. Klebsiella pneumoniae is a Gram-negative bacterium that causes bronchopneumonia, abscesses, urinary tract infection, osteomyelitis, and a wide variety of infections. The ubiquity of this microorganism confounds with the great increase in antibiotic resistance and have bred great concern worldwide. K. pneumoniae sequence type (ST) 307 is a widespread emerging clone associated with hospital-acquired infections, although sporadic community infections have also been reported. The aim of our study is to describe the first case of Klebsiella pneumoniae (ST) 307 harboring the blaOXA-48-like gene in Ecuador. We characterized a new plasmid that carry OXA-48 and could be the source of future outbreaks. The strain was recovered from a patient with cancer previously admitted in a Ukrainian hospital, suggesting that this mechanism of resistance could be imported. These findings highlight the importance of programs based on active molecular surveillance for the intercontinental spread of multidrug-resistant microorganisms with emergent carbapenemases.