Ingramthyssen8299

Mosquito-borne diseases, in particular malaria, have a significant burden worldwide leading to nearly half a million deaths each year. The malaria parasite requires a vertebrate host, such as a human, and a vector host, the Anopheles mosquito, to complete its full life cycle. Here, we focus on the parasite dynamics within the vector to examine the first appearance of sporozoites in the salivary glands, which indicates a first time of infectiousness of mosquitoes. The timing of this period of pathogen development in the mosquito until transmissibility, known as the extrinsic incubation period, remains poorly understood. HG106 ic50 We develop compartmental models of within-mosquito parasite dynamics fitted with experimental data on oocyst and sporozoite counts. We find that only a fraction of oocysts burst to release sporozoites and bursting must be delayed either via a time-dependent function or a gamma-distributed set of compartments. We use Bayesian inference to estimate distributions of parameters and determine that bursting rate is a key epidemiological parameter. A better understanding of the factors impacting the extrinsic incubation period will aid in the development of interventions to slow or stop the spread of malaria.The recent identification of the bio-duck call as Antarctic minke whale (AMW) vocalization allows the use of passive acoustic monitoring to retrospectively investigate year-round spatial-temporal patterns in minke whale occurrence in ice-covered areas. Here, we present an analysis of AMW occurrence patterns based on a 9-year passive acoustic dataset (2008-2016) from 21 locations throughout the Atlantic sector of the Southern Ocean (Weddell Sea). AMWs were detected acoustically at all mooring locations from May to December, with the highest presence between August and November (bio-duck calls present at more than 80% of days). At the southernmost recording locations, the bio-duck call was present up to 10 months of the year. Substantial inter-annual variation in the seasonality of vocal activity correlated to variation in local ice concentration. Our analysis indicates that part of the AMW population stays in the Weddell Sea during austral winter. The period with the highest acoustic presence in the Weddell Sea (September-October) coincides with the timing of the breeding season of AMW in lower latitudes. The bio-duck call could therefore play a role in mating, although other behavioural functions of the call cannot be excluded to date.One of the most effective methods of influencing what people like and dislike is to expose them to systematic patterns (or 'regularities') in the environment, such as the repeated presentation of a single stimulus (mere exposure), two or more stimuli (evaluative conditioning (EC)) or to relationships between stimuli and behaviour (approach/avoidance). Hughes et al. (2016) J. Exp. Psychol. Gen.145, 731-754. (doi10.1037/xge0000100) found that evaluations also emerge when regularities in the environment intersect with one another. In this paper, we examined if evaluations established via operant EC and intersecting regularities can be undermined via extinction or revised via counterconditioning. Across seven pre-registered studies (n = 1071), participants first completed a learning phase designed to establish novel evaluations followed by one of multiple forms of extinction or counterconditioning procedures designed to undo them. Results indicate that evaluations were-in general-resistant to extinction and counterconditioning. Theoretical and practical implications along with future directions are discussed.Traditionally, it had been assumed that meta-representational Theory of Mind (ToM) emerges around the age of 4 when children come to master standard false belief (FB) tasks. More recent research with various implicit measures, though, has documented much earlier competence and thus challenged the traditional picture. In interactive FB tasks, for instance, infants have been shown to track an interlocutor's false or true belief when interpreting her ambiguous communicative acts (Southgate et al. 2010 Dev. Sci.13, 907-912. (doi10.1111/j.1467-7687.2009.00946.x)). However, several replication attempts so far have produced mixed findings (e.g. Dörrenberg et al. 2018 Cogn. Dev.46, 12-30. (doi10.1016/j.cogdev.2018.01.001); Grosse Wiesmann et al. 2017 Dev. Sci.20, e12445. (doi10.1111/desc.12445); Király et al. 2018 Proc. Natl Acad. Sci. USA115, 11 477-11 482. (doi10.1073/pnas.1803505115)). Therefore, we conducted a systematic replication study, across two laboratories, of an influential interactive FB task (the so-called 'Sefo' tasks by Southgate et al. 2010 Dev. Sci.13, 907-912. (doi10.1111/j.1467-7687.2009.00946.x)). First, we implemented close direct replications with the original age group (17-month-olds) and compared their performance to those of 3-year-olds. Second, we designed conceptual replications with modifications and improvements regarding pragmatic ambiguities for 2-year-olds. Third, we validated the task with explicit verbal test versions in older children and adults. Results revealed the following the original results could not be replicated, and there was no evidence for FB understanding measured by the Sefo task in any age group except for adults. Comparisons to explicit FB tasks suggest that the Sefo task may not be a sensitive measure of FB understanding in children and even underestimate their ToM abilities. The findings add to the growing replication crisis in implicit ToM research and highlight the challenge of developing sensitive, reliable and valid measures of early implicit social cognition.Genetic markers are widely used in fisheries management around the world. While the genetic structure and markers selected are usually based on samples from the wild, very few controlled experiments have been carried out to investigate possible differences in influence on traits between markers. Here we examine the bi-allelic gene pantophysin (Pan I), widely used in the management of Atlantic cod, in a series of in vitro crosses under a range of temperatures. It has been proposed that this gene, or another tightly linked gene, may be under strong divergent selection. Resolving this issue is essential in order to interpret results when using this gene marker for stock management. We found no evidence of departure from the expected 1 2 1 Mendelian ratio for any of the three genotypes during the egg stage, while both the 6 and 12°C temperature regimes in tank experiments favoured the survival of the Pan IAA genotype. No difference in genotype survival was, however, found in a more natural mesocosm environment.