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The positive results previously seen using CentriMag as a right-sided Fontan support device were found to be repeatable across multiple patient anatomies and cannulations. While animal models and eventual patient studies will provide further insight into the efficacy of this support strategy, our findings here suggest this method may reproduce right heart function.The distal foot power equation is a simple yet powerful tool for estimating the power dissipation or generation within the foot even while modeling it as a rigid body. It was introduced over two decades ago, but has seen a resurgence of use in recent years. Nevertheless, the theoretical justification for this formula has thus far been limited. selleck compound It is difficult to properly use any equation and interpret the results from analyses using it without a solid understanding of how it is derived as well as its underlying assumptions. In this communication, a thorough derivation of the distal foot power equation is provided first for the case where the foot is interacting with a rigid ground without sliding and then second generalized for situations when the foot may slide relative to a deformable ground surface. For the first case, the derivation makes clear that distal foot power represents the power due to the deviation of the foot from a rigid body state for the portion of the foot between its mass center (or other point of reference) and the center of pressure. For the second case, distal foot power represents not only the internal deformation power of the foot, but also the power due to sliding of the foot on the ground and the power due to deformation of the ground near the point of contact.Achilles tendon ruptures are common injuries that lead to functional deficits in two-thirds of patients. Progressively loading the healing tendon has been associated with superior outcomes, but the loading profiles that patients experience throughout rehabilitation have not yet been established. In this study, we developed and calibrated an instrumented immobilizing boot paradigm that is aimed at longitudinally quantifying patient loading biomechanics to develop personalized rehabilitation protocols. We used a 3-part instrumented insole to quantify the ankle loads generated by the Achilles tendon and secured a load cell inline with the posterior strut of the immobilizing boot to quantify boot loading. We then collected gait data from five healthy young adults to demonstrate the validity of this instrumented immobilizing boot paradigm to assess Achilles tendon loading during ambulation. We developed a simple calibration procedure to improve the measurement fidelity of the instrumented insole needed to quantify Achilles tendon loading while ambulating with an immobilizing boot. By assessing Achilles tendon loading with the ankle constrained to 0 degrees and 30 degrees plantar flexion, we confirmed that walking with the foot supported in plantar flexion decreased Achilles tendon loading by 60% (P less then 0.001). This instrumented immobilizing boot paradigm leverages commercially available sensors and logs data using a small microcontroller secured to the boot and a handheld device, making our paradigm capable of continuously monitoring biomechanical loading outside of the lab or clinic.Experimental observations in the open literature indicate that soft tissues are slightly compressible, and this characteristic affects not only their overall elastic response but also their damage evolution and failure mechanism. In this study, we find that the compressibility of liver tissues is also closely related to the initial specimen volume according to the confined compression tests the samples with smaller initial volume exhibit more compressible behavior compared to the larger ones. To include this initial-volume dependent effect, we developed a novel volumetric strain energy model with two variables, i.e., the bulk modulus and the compressibility factor. A detailed scheme was proposed as well to identify these two parameters, and the relationship between the bulk modulus and the initial volume was clarified. Findings from this study will help to deepen the understanding of the biomechanical properties of soft tissues. STATEMENT OF SIGNIFICANCE Liver is a highly vascular organ and traditionally assumed to be an incompressible medium. However, through the confined compression tests, we found that the samples with smaller initial volumes exhibit more compressible behavior. Hence, we developed a novel strain energy density model to characterize the initial-volume dependent hyperelastic response, and found that the bulk modulus of liver tissues is positively related to the initial volume. Our results suggest that the compressibility of liver tissues should be considered in the future study of liver biomechanics.The rotator cuff is theorized to contribute to force couples required to produce glenohumeral kinematics. Impairment in these force couples would theoretically result in impaired ball-and-socket kinematics. Although less frequently used than traditional kinematic descriptors (e.g., Euler angles, joint translations), helical axes are capable of identifying alterations in ball-and-socket kinematics by quantifying the variability (i.e., dispersion) in axis orientation and position during motion. Consequently, assessing glenohumeral helical dispersion may provide indirect evidence of rotator cuff function. The purpose of this exploratory study was to determine the extent to which rotator cuff pathology is associated with alterations in ball-and-socket kinematics. Fifty-one participants were classified into one of five groups based on an assessment of the supraspinatus using diagnostic imaging asymptomatic healthy, asymptomatic tendinosis, asymptomatic partial-thickness tear, asymptomatic full-thickness tear, symptomatic full-thickness tear. Glenohumeral kinematics were quantified during coronal plane abduction using a biplane x-ray system and described using instantaneous helical axes. The degree to which glenohumeral motion coincided with ball-and-socket kinematics was described using the angular and positional dispersion about the optimal helical axis and pivot, respectively. No statistically significant difference was observed between groups in angular dispersion. However, symptomatic individuals with a full-thickness supraspinatus tear had significantly more positional dispersion than asymptomatic individuals with a healthy supraspinatus or tendinosis. These findings suggest that symptomatic individuals with a full-thickness supraspinatus tear exhibit impaired ball-and-socket kinematics, which is believed to be associated with a disruption of the glenohumeral force couples.