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7 months (range 8.8-10.5 months), and in Vp4 PVTT, the TTP was 4.2 months (range 2.8-5.6 months). The median OS was 10.0 months (range 7.0-13.1 months). In Vp3 PVTT, OS was 11.9 months (range 9.2-14.5 months), and in Vp4 PVTT, OS was 7.2 months (range 3.8-10.7 months). Conclusions PVS-125I-TACE-S is safe for patients with HCC with PVTT and may extend the TTP and survival of patients with Vp4 PVTT. Advances in knowledge PVS implantation promptly restored flow in the obstructed portal vein, which can reduce the risk of hepatic failure and upper gastrointestinal bleeding. Implantation of iodine-125 seed-strips may directly expose the portal tumor thrombus to radiation and kill cancer cells. Their combined use with TACE-S has a strong scientific rationale.Racemic γ-substituted allenes undergo enantioselective higher order [8 + 2]-cycloaddition with azaheptafulvenes using a chiral amino acid derived amidophosphine as catalyst, providing the corresponding azaazulenoid cycloadducts with excellent levels of regio-, diastereo-, and enantioselectivities. In this reaction, the activated allylic phosphonium ylide intermediate participates as the C2-component of the reaction, in contrast to the conventional reactivity of this type of zwitterionic intermediates as C3-components in cycloaddition reactions.Carbon nanobelts are cylindrical molecules composed of fully fused edge-sharing arene rings. Because of their aesthetically appealing structures, they acquire unusual optoelectronic properties that are potentially suitable for a range of applications in nanoelectronics and photonics. Nevertheless, the very limited success of their synthesis has led to their photophysical properties remaining largely unknown. Compared to that of carbon nanorings (arenes linked by single bonds), the strong structural rigidity of nanobelts prevents significant deformations away from the original high-symmetry conformation and, therefore, impacts their photophysical properties. Herein, we study the photoinduced dynamics of a successfully synthesized belt segment of (6,6)CNT (carbon nanotube). Modeling this process with nonadiabatic excited state molecular dynamics simulations uncovers the critical role played by the changes in excited state wave function localization on the different types of carbon atoms. This allows a detailed description of the excited state dynamics and spatial exciton evolution throughout the nanobelt scaffold. Our results provide detailed information about the excited state electronic properties and internal conversion rates that is potentially useful for designing nanobelts for nanoelectronic and photonic applications.It is highly desirable to control the carrier lifetime in two-dimensional (2D) materials to suit the needs of various device functionalities. In this work, by ab initio nonadiabatic molecular dynamics simulation, we find the single atom doping from phosphorus family elements can sufficiently tune the carrier lifetime in black phosphorene (BP). Instead of forming electron-hole (e-h) recombination centers, the e-h recombination is suppressed by doping compared with the pristine BP. Moreover, it is found the carrier lifetime has a strong correlation with the mass of the doping atoms. A doping atom with larger mass leads to a longer lifetime. With the heaviest family element Bi doping, the carrier lifetime increases from 0.29 to 5.34 ns. This trend can be understood from the reduction of the nuclear velocity due to the heavy doping atom. We propose this conclusion can be extended to other monoelemental 2D semiconductors, which provides important guidance for the future design of functional nanodevices.Naturally stimulated dynamic ordering-disordering of biomolecules via noncovalent interactions is a commonly occurring phenomenon in biological systems. Herein, we report the effect of induced polarization on the charge carrier dynamics of carbon-quantum-dot-based nano ionic materials (CQD-NIMs) under simulated solar radiation. The solventless liquid-like CQD-NIMs is composed of polystyrenesulfonate (PSS)-passivated CQD as the core-corona system with a polyetheramine (Jeffamine) forming the canopy. The material was observed to behave as a dielectric when placed between two electrodes. Dynamic ordering-disordering of the corona around the CQD surface under induced polarization allowed excess current flow through the solventless material when exposed to simulated solar radiation. Such reversible molecular-assembly-induced photoconducting behavior of the CQDs was characterized with impedance spectroscopy and steady state fluorescence spectroscopy. The concept depicted in the present manuscript may be further developed to design smart light-sensitive molecular switching devices.Microcystins, cyclic nonribosomal heptapeptides, are the most well-known cyanobacterial toxins. They are exceptionally well studied, but open questions remain concerning their physiological role for the producing microorganism or their suitability as lead compounds for anticancer drug development. One means to study specialized metabolites in more detail is the introduction of functional groups that make a compound amenable for bioorthogonal, so-called click reactions. selleck chemicals Although it was reported that microcystins cannot be derivatized by precursor-directed biosynthesis, we successfully used this approach to prepare clickable microcystins. Supplementing different azide- or terminal alkyne containing amino acid analogues into the cultivation medium of microcystin-producing cyanobacteria strains, we found that these strains differ strongly in their substrate acceptance. Exploiting this flexibility, we generated more than 40 different clickable microcystins. We conjugated one of these derivatives with a fluorogenic dye and showed that neither incorporation of the unnatural amino acid analogue nor attachment of the fluorescent label significantly affects the cytotoxicity against cell lines expressing the human organic anion transporting polypeptides 1B1 or 1B3. Using time-lapse microscopy, we observed that the fluorescent microcystin is rapidly taken up into eukaryotic cells expressing these transporters.