Lindholmmathews2621

In the LH-RH alone group, it appears that there are no 4+ colloid density and less damage. According to these findings, the negative effect of LH-RH treatment on cavernosal tissues appears to be less. © 2020 Blackwell Verlag GmbH.We herein report a novel mutation in familial progressive hyper- and hypopigmentation (FPHH). The KITLG gene encoding the KIT ligand protein is a disease-causing gene for FPHH. Various disease-causing gain-of-function mutations, which reside within or adjacent to the conserved VTNN motif of this gene, have been described to date. We have now identified a novel KITLG mutation, c.337G>A (p.Glu113Lys), in FPHH which is located within another ligand-receptor interaction site. © 2020 Japanese Dermatological Association.Broad and unspecific use of antibiotics accelerates spread of resistances. Sensitive and robust pathogen detection is thus important for a more targeted application. Bacteriophages contain a large repertoire of pathogen-binding proteins. These tailspike proteins (TSP) often bind surface glycans and represent a promising design platform for specific pathogen sensors. We analyzed bacteriophage Sf6 TSP that recognizes the O-polysaccharide of dysentery-causing Shigella ( S. ) flexneri to develop variants with increased sensitivity for sensor applications. Ligand polyrhamnose backbone conformations were obtained from 2D 1 H, 1 H-trNOESY NMR utilizing methine-methine and methine-methyl correlations. They agreed well with conformations obtained from molecular dynamics (MD), validating the method for further predictions. In a set of mutants, MD predicted ligand flexibilities that were in good correlation with binding strength as confirmed on immobilized S. flexneri O-polysaccharide with surface plasmon resonance. Atamparib mouse In silico approaches combined with rapid screening on PS surfaces hence provide valuable strategies for TSP-based pathogen sensor design. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Circle hair (CH) is rare disorder of unknown etiology characterized by body hairs growing in a circular manner. Cases in the literature, describe no association of CH with diseases or medications. We present a patient with CH appearing after heart transplantation. This article is protected by copyright. All rights reserved.AIM To investigate the association among iron overload, periodontal status, and periodontitis progression rate in sickle cell anemia (SCA). MATERIALS AND METHODS This case series evaluated 123 patients. Clinical attachment level (CAL) and probing depth (PD) were evaluated at six sites per tooth. Alveolar bone loss was estimated using periapical radiography. Study outcomes were periodontal status (measured as number of sites with CAL of ≥3 mm, CAL of ≥5 mm, PD of ≥4 mm, and PD of ≥6 mm) and periodontitis progression rate (determined as ratio of alveolar bone loss to age). Serum transferrin saturation and ferritin levels were obtained from medical records. Poisson regression was performed to estimate associations. Covariables included in the adjusted models (comorbidities, skin color, socioeconomic class, and vaso-occlusive crisis) were defined by DAGs. RESULTS Serum transferrin saturation level revealed a significant positive association with the number of sites with CAL of ≥3 mm, CAL of ≥5 mm, PD of ≥4 mm, and PD of ≥6 mm. Patients with serum transferrin saturation level of >45% were 1.93 times more likely to have rapid periodontitis progression. CONCLUSION High serum transferrin saturation level is associated with a greater extent of periodontitis and rapid periodontitis progression in SCA. This article is protected by copyright. All rights reserved.BACKGROUND Despite extensive research on risk factors and mechanisms, the extent to which interpregnancy interval (IPI) affects hypertensive disorders of pregnancy in high-income countries remains unclear. OBJECTIVES To examine the association between IPI and hypertensive disorders of pregnancy in a high-income country setting using both within-mother and between-mother comparisons. METHODS A retrospective population-based cohort study was conducted among 103 909 women who delivered three or more consecutive singleton births (n = 358 046) between 1980 and 2015 in Western Australia. We used conditional Poisson regression with robust variance, matching intervals of the same mother and adjusted for factors that vary within-mother across pregnancies, to investigate the association between IPI categories (reference 18-23 months), and the risk of hypertensive disorders of pregnancy. For comparison with previous studies, we also applied unmatched Poisson regression (between-mother analysis). RESULTS The incidence of preeclampsia and gestational hypertension during the study period was 4%, and 2%, respectively. For the between-mother comparison, mothers with intervals of 6-11 months had lower risk of preeclampsia with adjusted relative risk (RR) 0.92 (95% confidence interval [CI] 0.85, 0.98) compared to reference category of 18-23 months. With the within-mother matched design, we estimated a larger effect of long IPI on risk of preeclampsia (RR 1.29, 95% CI 1.18, 1.42 for 60-119 months; and RR 1.30, 95% CI 1.10, 1.53 for intervals ≥120 months) compared to 18-23 months. Short IPIs were not associated with hypertensive disorders of pregnancy. CONCLUSIONS In our cohort, longer IPIs were associated with increased risk of preeclampsia. However, there was insufficient evidence to suggest that short IPIs ( less then 6 months) increase the risks of hypertensive disorders of pregnancy. © 2020 John Wiley & Sons Ltd.Amphibian populations globally are in decline. One important threat is the abstraction of water resources that alter surface-water hydrology. Conservation actions aimed at restoring or manipulating surface-water is frequently employed as a management tool, but empirical evidence on the effectiveness of these approaches is scarce. In this systematic review we summarise the global experience of manipulating water for amphibian conservation. We explore examples of manipulating water to conserve amphibian species and communities. Approaches vary in their frequency of implementation and in their success. Extending hydroperiod to match larval requirements shows encouraging results, as does off-season drying to control predators. Spraying water into the environment has several potential applications, but successes are limited. Despite some promising interventions, we identified few (n = 17) empirically supported examples of successful water manipulation to benefit amphibians. It is unclear if this stems from publication bias or if it is an artefact of language selection.