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Salmonellosis is an important food borne disease of public health significance. Global estimates of the disease burden shows more than 20 million cases and 0.15 million deaths annually. The disease caused by a variety of Salmonella organisms worldwide. Salmonella pathogens are belonging to family Enterobacteriaceae that are known to infect many hosts inducing variable clinical diseases pictures. Typhoidal and non-typhoidal Salmonellae are common diseases among Egyptians with severe socioeconomic losses. Different species of animals and poultry as well as their products are the main sources and reservoirs for zoonotic human illness. Enteric fever and gastroenteritis are the main clinical manifestations in patients. Great attention toward salmonellosis drug resistance, prevention and control should be considered.We thank Dr Kanagala and Professor Squire for their keen interest in our paper and their insight into the challenge of grading left ventricular ejection fraction (LVEF). We must emphasise that our paper's remit was not to be a clinical guide on heart failure nor on its treatment. We have briefly outlined the rationale and context for the BSE cutoff for severe LVEF and why we continue to differ from our European and American colleagues. We then discuss the need for stating the actual LVEF% in reports as opposed to a category alone for guiding appropriate therapeutic choices. Finally we address the concerns raised over clinical harm they perceive may occur from adopting our guideline.

Growing evidence indicated the higher risk of suicide in cancer survivors compared with general population. N6-methyladenosine cell line Our aim is to systematically quantify the extent of suicide death and identify risk factors associated with the incidence of suicide in cancer patients.

We conducted a meta-analysis of relevant studies published in English or Chinese before May 20, 2020. Suicide rate and the number of suicide death were extracted. Our main outcome was suicide rate per 100,000 person-years with 95% CIs using random-effects model.

The pooled incidence of suicide death was 39.72 per 100,000 person-years (95%CI, 33.91-46.52, I

= 99.6%, P <0 .001).The suicide rate for cancer patients was higher in men (57.78, 95%CI, 47.31-70.56) than in women (14.47, 95%CI, 11.27-18.57). For both sexes combined, esophagus cancer had the highest rate of suicide (87.71, 95%CI, 27.42-280.54). By sex, suicide rates ranked first in males and females were pancreas cancer (195.70, 95%CI, 129.55-295.61) and esophagus cancer (18.34, 95%CI, 5.92-56.84), respectively. The highest suicide rate was 61.02(95%CI, 53.66-69.40) in Asia, and Oceania (24.07, 95%CI, 20.78-27.88) had lowest suicide rate. Suicide rate had a downward trend by years after diagnosis, with the first six months after cancer diagnosis clearly standing out (89.33, 95%CI, 50.64-157.58).

Included studies came from high-income countries and our results might not represent the suicide rate among cancer patients in low- and middle-income countries.

The incidence of suicide among cancer patients was high despite the declined trend recent years, which emphasized psychological health aspects of interventions and perfecting suicide prevention programs.

The incidence of suicide among cancer patients was high despite the declined trend recent years, which emphasized psychological health aspects of interventions and perfecting suicide prevention programs.

Few evidence-based treatments for eating disorders (EDs) exist. Imaginal exposure therapy is a key component of effective treatment for anxiety disorders and post-traumatic stress disorder. However, imaginal exposure has not been systematically tested as a treatment for EDs. The current study aimed to develop and test online imaginal exposure as a treatment for EDs.

The current study tested a four-week trial of online imaginal exposure for EDs (N=229 participants with EDs recruited globally). Participants completed diagnostic interviews and four sessions of weekly online imaginal exposure, in which they wrote about and imagined a core ED fear (identified with a therapist). Participants completed measures of ED symptoms and fears (i.e., fear of weight gain, food) at pre-imaginal exposure, post-imaginal exposure, and six-month follow-up. Participants were recruited and participated in the protocol from November 2016 to October 2018.

All primary outcomes (ED symptoms, ED fears) significantly decreased at study completion and six-month follow-up with medium-to-large effect sizes. State anxiety across the exposure and follow-ups significantly decreased, specifically from initial sessions to follow-up. Worry, but not depression, significantly decreased.

This study was an open case trial and did not include a control condition.

Significant decreases in ED symptoms and fears occurred during the course of imaginal exposure treatment. Online imaginal exposure is a feasible treatment for EDs and is associated with decreases in core ED symptomatology, which are comparable in magnitude to decreases seen from other evidence-based treatments. A future randomized-controlled trial is needed.

ClinicalTrials.gov identifier NCT03712748.

ClinicalTrials.gov identifier NCT03712748.

Evidence suggests that extinction during memory reconsolidation diminishes the return of defensive responses. In order to translate these effects to the clinical setting, we tested whether retrieving a traumatic memory and delivering a brief two-sessions imaginal exposure intervention during its reconsolidation would produce stronger decreases in reactivity to these memories than standard imaginal exposure method.

Participants with Post-Traumatic Stress Disorder (PTSD) had either their traumatic (n=21) or a neutral (n=21) memory retrieved 1h before an imaginal exposure session for two consecutive days. One day before and one day after, participants were exposed to script-driven imagery of their traumatic event, during which skin conductance responses were measured and, immediately after, subjective responses were assessed by means of Visual Analogue Scales.

Traumatic retrieval improved the physiological, but not the subjective effects of imaginal exposure intervention on over-reactivity to traumatic memories.